Melanoma risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Anum Ijaz M.B.B.S., M.D.[2]; Yazan Daaboul, M.D.; Serge Korjian M.D.
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Melanoma Microchapters |
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2019 AAD Guidelines for management of Primary Cutaneous Melanoma (CM) |
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Melanoma risk factors On the Web |
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Overview
The two most potent risk factors in the development of melanoma are light-colored skin and exposure to ultraviolet radiation. Other risk factors include old age, male gender, family history of melanoma, personal history of skin cancers, immunodeficiency, and certain hereditary disorders.
Risk Factors
- The two most potent risk factors in the development of melanoma are light-colored skin and exposure to ultraviolet radiation.[1][2]
- Other risk factors for the development of melanoma are mentioned in the table below:
| Risk Factors | |
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| Heritable |
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| Modifiable |
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| Non-modifiable Risk Factors | |
* Fitzpack Patrick phototypes: Ⅰ( always burns, never tans), Ⅱ ( usually burns, tans less than average), Ⅲ ( sometimes mild burns, tans about average), and IV( rarely burns, tans more than average).[9]
References
- ↑ 1.0 1.1 1.2 Ghiasvand R, Rueegg CS, Weiderpass E, Green AC, Lund E, Veierød MB (February 2017). "Indoor Tanning and Melanoma Risk: Long-Term Evidence From a Prospective Population-Based Cohort Study". Am. J. Epidemiol. 185 (3): 147–156. doi:10.1093/aje/kww148. PMID 28077359.
- ↑ Leiter U, Garbe C (2008). "Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight". Adv. Exp. Med. Biol. 624: 89–103. doi:10.1007/978-0-387-77574-6_8. PMID 18348450.
- ↑ 3.0 3.1 3.2 3.3 3.4 Joshi UM, Kashani-Sabet M, Kirkwood JM (August 2025). "Cutaneous Melanoma: A Review". JAMA. doi:10.1001/jama.2025.13074. PMID 40853557 Check
|pmid=value (help).- Hair color (red or blonde).Joshi UM, Kashani-Sabet M, Kirkwood JM (August 2025). "Cutaneous Melanoma: A Review". JAMA. doi:10.1001/jama.2025.13074. PMID 40853557 Check
|pmid=value (help).
- Hair color (red or blonde).Joshi UM, Kashani-Sabet M, Kirkwood JM (August 2025). "Cutaneous Melanoma: A Review". JAMA. doi:10.1001/jama.2025.13074. PMID 40853557 Check
- ↑ Herraiz C, Jiménez-Cervantes C, Sánchez-Laorden B, García-Borrón JC (June 2018). "Functional interplay between secreted ligands and receptors in melanoma". Semin. Cell Dev. Biol. 78: 73–84. doi:10.1016/j.semcdb.2017.06.021. PMID 28676423.
- ↑ Francis JH, Levin AM, Abramson DH (2016). "Update on Ophthalmic Oncology 2014: Retinoblastoma and Uveal Melanoma". Asia Pac J Ophthalmol (Phila). 5 (5): 368–82. doi:10.1097/APO.0000000000000213. PMID 27632029.
- ↑ Naouali C, Jones M, Nabouli I, Jerbi M, Tounsi H, Ben Rekaya M, Ben Ahmed M, Bouhaouala B, Messaoud O, Khaled A, Zghal M, Abdelhak S, Boubaker S, Yacoub-Youssef H (January 2017). "Epidemiological trends and clinicopathological features of cutaneous melanoma in sporadic and xeroderma pigmentosum Tunisian patients". Int. J. Dermatol. 56 (1): 40–48. doi:10.1111/ijd.13448. PMID 27785785.
- ↑ Yin L, Pang G, Niu C, Habasi M, Dou J, Aisa HA (June 2018). "A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells". Int. J. Mol. Med. 41 (6): 3727–3735. doi:10.3892/ijmm.2018.3529. PMID 29512683.
- ↑ Müller C, Wendt J, Rauscher S, Sunder-Plassmann R, Richtig E, Fae I, Fischer G, Okamoto I (December 2018). "Risk Factors of Subsequent Primary Melanomas in Austria". JAMA Dermatol. doi:10.1001/jamadermatol.2018.4645. PMID 30566178.
- ↑ Gupta V, Sharma VK (2019). "Skin typing: Fitzpatrick grading and others". Clin Dermatol. 37 (5): 430–436. doi:10.1016/j.clindermatol.2019.07.010. PMID 31896400.