Macrocytic anemia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2] Omer Kamal, M.D.[3]


The common causes of megaloblastic anemia are less dietray intake, autoimmune disorders like pernicious anemia, alcoholism, increased demands like in pregnancy and due to drugs.


Common Causes

Common causes of macrocytic anemia may include: causes of megaloblastic anemia and non megaloblastic anemia:[1][2][3]


Non megaloblastic

Less Common Causes

Less common causes of macrocytsic anemia include: [4]

Genetic Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Amobarbital sodium, Cycloserine, Cytarabine, Ethotoin, Folic acid antagonists (methotrexate), Pergolide, Purine antagonists (6-mercaptopurine), Pyrimidine antagonists (cytosine arabinoside), Phenobarbital, Pyrimethamine, Secobarbital sodium, Trimethoprim
Ear Nose Throat No underlying causes
Endocrine Hypothyroidism
Environmental No underlying causes
Gastroenterologic Chronic liver diseases, diverticulosis, fistula, intestinal anastomosis, achlorhydria
Genetic Lesch-Nyhan Syndrome, Methylmalonic aciduria, Orotic aciduria
Hematologic Myelodysplasia, Pernicious anemia, Reticulocytosis
Iatrogenic No underlying causes
Infectious Disease Diphyllobothrium latum
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Alcoholism, Folate deficiency,Orotic aciduria, Vitamin B12 deficiency
Obstetric/Gynecologic Pregnancy
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order:


  1. Savage DG, Ogundipe A, Allen RH, Stabler SP, Lindenbaum J (June 2000). "Etiology and diagnostic evaluation of macrocytosis". Am. J. Med. Sci. 319 (6): 343–52. PMID 10875288.
  2. Nagao T, Hirokawa M (October 2017). "Diagnosis and treatment of macrocytic anemias in adults". J Gen Fam Med. 18 (5): 200–204. doi:10.1002/jgf2.31. PMC 5689413. PMID 29264027.
  3. Savage DG, Ogundipe A, Allen RH, Stabler SP, Lindenbaum J (June 2000). "Etiology and diagnostic evaluation of macrocytosis". Am. J. Med. Sci. 319 (6): 343–52. PMID 10875288.
  4. Rosenblatt DS, Whitehead VM (January 1999). "Cobalamin and folate deficiency: acquired and hereditary disorders in children". Semin. Hematol. 36 (1): 19–34. PMID 9930566.

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