Lipid Management in Diabetics

2016 ADA Guideline Recommendations
Types of Diabetes Mellitus
Main Diabetes Page
Diabetes type I
Diabetes type II
Gestational Diabetes Mellitus
2016 ADA Standard of Medical Care Guideline Recommendations
Strategies for Improving Care
Classification and Diagnosis of Diabetes
Foundations of Care and Comprehensive Medical Evaluation Diabetes Self-Management, Education, and Support Nutritional Therapy
Prevention or Delay of Type II Diabetes
Glycemic Targets
Obesity Management for Treatment of Type II Diabetes
Approaches to Glycemic Treatment
Cardiovascular Disease and Risk Management Hypertension and Blood Pressure Control Lipid Management Antiplatelet Agents Coronary Heart Disease
Microvascular Complications and Foot Care Diabetic Kidney Disease Diabetic Retinopathy Diabetic Neuropathy Diabetic Footcare
Older Adults with Diabetes
Children and Adolescents with Diabetes Management of Cardiovascular Risk Factors in Children and Adolescents with Diabetes Microvascular Complications in Children and Adolescents with Diabetes
Management of Diabetes in Pregnancy
Diabetes Care in the Hospital Setting

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivani Chaparala M.B.B.S [2]; Seyedmahdi Pahlavani, M.D. [3]; Tarek Nafee, M.D. [4] Nehal Eid, M.D.[5]

2025 ADA Standards of Medical Care in Diabetes Guidelines

"9. For people 40 to 75 years of age at higher cardiovascular risk, including those with ≥1 risk factor for atherosclerotic cardiovascular disease, use high intensity statin therapy to reduce LDL cholesterol by ≥50% of baseline value and to target an LDL cholesterol goal of <70 mg/dl. (Level of Evidence: A)"

Special population: Children

For children older than 10 years with type 1 diabetes who have LDL cholesterol ≥130 mg/dL (≥3.4 mmol/L) despite medical nutrition therapy and lifestyle changes (Level of Evidence: E).

2016 ADA Standards of Medical Care in Diabetes Guidelines

"1.In adults not taking statins, it is reasonable to obtain a lipid profile at the time of diabetes diagnosis, at an initial medical evaluation, and every 5 years thereafter, or more frequently if indicated. (Level of Evidence: E)"

"2. Obtain a lipid profile at initiation of statin therapy and periodically thereafter as it may help to monitor the response to therapy and inform adherence. (Level of Evidence: E)"

"3.Lifestyle modification focusing on weight loss (if indicated); the reduction of saturated fat, trans fat, and cholesterol intake; increase of omega-3 fatty acids, viscous fiber, and plant stanols/sterols intake; and increased physical activity should be recommended to improve the lipid profile in patients with diabetes. (Level of Evidence: A)"

"4.Intensify lifestyle therapy and optimize glycemic control for patients with elevated triglyceride levels (≥ 150 mg/dL [1.7 mmol/L]) and/or low HDL cholesterol (<40 mg/dL [1.0 mmol/L] for men, <50 mg/dL [1.3 mmol/L] for women. (Level of Evidence: C)"

"5.For patients with fasting triglyceride levels ≥ 500 mg/dL (5.7 mmol/L), evaluate for secondary causes of hypertriglyceridemia and consider medical therapy to reduce the risk of pancreatitis. (Level of Evidence: C)"

"6.For patients of all ages with diabetes and atherosclerotic cardiovascular disease, high-intensity statin therapy should be added to lifestyle therapy. (Level of Evidence: A)"

"7.For patients with diabetes aged <40 years with additional atherosclerotic cardiovascular disease risk factors, consider using moderate- intensity or high-intensity statin and lifestyle therapy. (Level of Evidence: C)"

"8.For patients with diabetes aged 40–75 years without additional atherosclerotic cardiovascular disease risk factors, consider using moderate-intensity statin and lifestyle therapy.(Level of Evidence: A)"

"9.For patients with diabetes aged 40–75 years with additional atherosclerotic cardiovascular disease risk factors, consider using high-intensity statin and lifestyle therapy. (Level of Evidence: B)"

"10. For patients with diabetes aged >75 years without additional atherosclerotic cardiovascular disease risk factors, consider using moderate-intensity statin therapy and lifestyle therapy (Level of Evidence: B)"

"11.For patients with diabetes aged >75 years with additional atherosclerotic cardiovascular disease risk factors, consider using moderate- intensity or high-intensity statin therapy and lifestyle therapy. (Level of Evidence: B)"

"12.In clinical practice, providers may need to adjust intensity of statin therapy based on individual patient response to medication (e.g., side effects, tolerability, LDL cholesterol levels) (Level of Evidence: E)"

"13.The addition of ezetimibe to moderate-intensity statin therapy has been shown to provide additional cardiovascular benefit compared with moderate-intensity statin therapy alone and may be considered for patients with a recent acute coronary syndrome with LDL cholesterol >50 mg/dL (1.3 mmol/L) or for those patients who cannot tolerate high- intensity statin therapy (Level of Evidence: A)"

"14.Combination therapy (statin/fibrate) has not been shown to improve ath- erosclerotic cardiovascular disease outcomes and is generally not rec- ommended. A However, therapy with statin and fenofibrate may be considered for men with both triglyceride level >204 mg/dL (2.3 mmol/L) and HDL cholesterol level <34 mg/dL (0.9 mmol/L) (Level of Evidence: B)"

"15.Combination therapy (statin/niacin) has not been shown to provide additional cardiovascular benefit above statin therapy alone and may increase the risk of stroke and is not generally recommended (Level of Evidence: A)"

"16.Statin therapy is contraindicated in pregnancy. (Level of Evidence: B)"