Indigestion causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Common Causes

  • Eating fatty foods
  • Eating just before sleeping
  • Eating spicy foods
  • Eating too late in the evening
  • Excess caffeine consumption

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning 4-Chlorodehydromethyltestosterone, Amanita phalloides, Smoking, Sodium dichloroisocyanurate
Dermatologic No underlying causes
Drug Side Effect 4-Chlorodehydromethyltestosterone, Adefovir (patient information), acarbose, Aspirin and many other painkillers, alendronate, Atazanavir (patient information), Calcium channel blockers, Cholestyramine (patient information), Cholestyramine Resin (patient information), Colofac, Cyclobenzaprine, Desmopressin, Duloxetine, erythromycin, Efavirenz (patient information), Estrogen and Oral contraceptives, Emtricitabine (patient information), Epoetin Alfa Injection (patient information), Etodolac, Fentanyl Skin Patches (patient information), Frovatriptan (patient information), Imatinib (patient information), Interferon Beta-1b Injection (patient information), Ketorolac tromethamine, Lithium (patient information), Methotrexate, methylxanthines, metronidazole , Meropenem Injection (patient information), metformin, Netupitant and palonosetron, Olsalazine, Oxycodone, orlistat, Potassium supplements, Pergolide (patient information), Pramlintide injection (patient information), Quetiapine (patient information), Rifabutin, Rivastigmine (patient information), Simvastatin, Tadalafil, Tiotropium Oral Inhalation (patient information), Steroid medications, Thyroid medicines
Ear Nose Throat No underlying causes
Endocrine Carcinoid syndrome, Diabetes mellitus, hyperparathyroidism , Hyperthyroidism, Primary hyperparathyroidism
Environmental Multiple chemical sensitivity
Gastroenterologic Achlorhydria, Acid reflux / Heartburn, Acute viral hepatitis, Adult hypertrophic pyloric stenosis, Aerophagy, Cholecystitis, Chronic hepatitis, Acute and chronic Pancreatitis, Cirrhosis of liver, Coeliac disease, Colonic cancer, Crohn's disease, Duodenal cancer, Duodenal lymphoma, Duodenal polyps, Duodenal ulcer, Duodenal webs, Duodenitis, Esophageal carcinoma, Esophagitis, Gallstones, Gastric cancer, Gastric lymphoma, Gastric motility disorder, Gastric ulcer, Gastritis, Gastroesophageal reflux disease, Gastrointestinal tumors, Hiatus hernia, Hypertrophic gastritis, Intestinal motility disorder, Intestinal obstruction, Irritable bowel syndrome, Malabsorption, Ménétriér's disease, Pancreatic cancer, Peptic ulcers, Small intestinal bacterial overgrowth, Tropical sprue, Ulcerative colitis, Hepatoma, Ischemic bowel disease
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Amebic dysentery, Fascioliasis, Gastrointestinal mucormycosis, Giardiasis, H. Pylori, Hookworm, Opisthorchiasis, Strongyloidiasis, Syphilis, Tuberculosis
Musculoskeletal / Ortho No underlying causes
Neurologic Autonomic neuropathy
Nutritional / Metabolic Diabulimia, Eating fatty foods, Eating just before sleeping, Eating spicy foods, Eating too late in the evening, Excess alcohol consumption, Excess caffeine consumption, Garlic, Indian gooseberry, Overeating, Suillus luteus
Obstetric/Gynecologic No underlying causes
Oncologic Ovarian cancer, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue, Colonic cancer, Duodenal cancer, Duodenal lymphoma, Esophageal carcinoma, Gastric cancer, Gastric lymphoma, Gastrointestinal tumors, Pancreatic cancer
Opthalmologic No underlying causes
Overdose / Toxicity Niacin, Vitamin C
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte Hypercalcaemia, Uremia
Rheum / Immune / Allergy Oral allergy syndrome, Sarcoidosis, Scleroderma
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Couvade, Gulf War syndrome, Alcohol, Gas, Stress, Tobacco, Obesity, SSRI discontinuation syndrome, Trichophagia

Causes in Alphabetical Order