Hereditary nonpolyposis colorectal cancer natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

If left untreated, hereditary nonpolyposis colorectal cancer progression occurs rapidly and is then followed by sentinel organ cancer or metastasis. Hereditary nonpolyposis colorectal cancer is an aggressive syndrome characterized by early onset of cancer. Affected organs include endometrium (second most common after colon), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. Complications of hereditary nonpolyposis colorectal cancer are usually related to the surgery. The 5-year relative survival of patients with hereditary nonpolyposis colorectal cancer is approximately 79.3%. A feature associated with worse prognosis is late stage diagnosis.

Natural History, Complications, and Prognosis

Natural History

Prognosis

  • The 5-year relative survival of patients with hereditary nonpolyposis colorectal cancer is approximately 79.3%.[2]

Complications

  • Complications that can develop as a result of hereditary nonpolyposis colorectal cancer are sentinel organ tumors, such as:

References

  1. Hereditary nonpolyposis colorectal cancer. Dr Amir Rezaee. Radiopedia. http://radiopaedia.org/articles/hereditary-non-polyposis-colorectal-cancer-1 Accessed on December 3, 2015
  2. Vasen HF, Watson P, Mecklin JP, Lynch HT (1999). "New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC". Gastroenterology. 116 (6): 1453–6. PMID 10348829.


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