Gastrointestinal stromal tumor natural history

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Gastrointestinal stromal tumor Microchapters


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Natural History, Complications and Prognosis



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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]


If left untreated, patients with gastrointestinal stromal tumors (GIST) may progress to develop abdominal pain, abdominal distension and perforation. A benign GIST may remain unchanged for years before its progression into malignancy. A GIST may rupture and lead to intra-abdominal or gastrointestinal bleeding. Ultimately, the GIST may metastasize and turn fatal. Common complications of GIST include bowel obstruction, bowel perforation, and peritonitis. Depending on the extent of the tumor at the time of diagnosis, the prognosis of GIST may vary. Prognosis of GIST depends upon size, location, spread and mitotic rate of the tumor. A benign GIST treated with surgical resection has much more better outcome as compared to patients with malignant GIST.

Natural history


Common complications of GIST include:[2]



  1. Antonopoulos P, Leonardou P, Barbagiannis N, Alexiou K, Demonakou M, Economou N (2014). "Gastrointestinal and extragastrointestinal stromal tumors: report of two cases and review of the literature". Case Rep Gastroenterol. 8 (1): 61–6. doi:10.1159/000354724. PMC 3975174. PMID 24707244.
  2. Sorour MA, Kassem MI, Ghazal A, El-Riwini MT, Abu Nasr A (2014). "Gastrointestinal stromal tumors (GIST) related emergencies". Int J Surg. 12 (4): 269–80. doi:10.1016/j.ijsu.2014.02.004. PMID 24530605. Vancouver style error: initials (help)
  3. "Risk Assessment and Prognosis".
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  8. Carney JA (1999). "Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence". Mayo Clin. Proc. 74 (6): 543–52. doi:10.4065/74.6.543. PMID 10377927.