Craniopharyngioma natural history, complication and prognosis
Craniopharyngioma natural history, complication and prognosis On the Web
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If left untreated, majority of patients with craniopharyngioma may progress to develop increased intracranial pressure, blindness and endocrine abnormalities. The prognosis of craniopharyngioma is good with treatment. The 5-year and 10-year survival rates are higher than 90%.
- Craniopharyngiomas are slow growing tumors and symptoms often are present for a year or more before the diagnosis is established.
- Untreated patients can have increased intracranial pressure, visual disturbances and endocrine abnormalities.
- A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated.
- Tumor may reoccur if it is not completely removed.
- Hypothalamic-sparing surgical techniques may result in reduced postoperative obesity without an increase in tumor recurrence.
- Hormone replacement therapy
- Severe behavioral problems
- Spinal fluid leak
- False aneurysms
- Difficulty with eye movements
- Death from intraoperative hemorrhage, hypothalamic damage, or stroke (rare)
- Craniopharyngioma is a benign tumor, the 5-year and 10-year survival rates, regardless of treatment given, are higher than 90%.
- Patients can have a permanent cure if the tumor can be completely removed with surgery or treated with high doses of radiation.
- The outlook depends on whether or not the tumor can be removed by surgery.
- The neurological deficits and hormonal imbalances caused by the tumor and the treatment the patient’s general health.
- Recent research has demonstrated malignant tendency of craniopharyngiomas.
- These malignant craniopharyngiomas are very rare but are associated with poor prognosis.
- Wijnen M, van den Heuvel-Eibrink MM, Janssen J, Catsman-Berrevoets CE, Michiels E, van Veelen-Vincent MC, Dallenga A, van den Berge JH, van Rij CM, van der Lely AJ, Neggers S (June 2017). "Very long-term sequelae of craniopharyngioma". Eur. J. Endocrinol. 176 (6): 755–767. doi:10.1530/EJE-17-0044. PMID 28325825. Vancouver style error: initials (help)
- Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- Complications. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- Müller HL (June 2014). "Craniopharyngioma". Endocr. Rev. 35 (3): 513–43. doi:10.1210/er.2013-1115. PMID 24467716.
- Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- Sofela, AA; Hettige, S; Curran, O; Bassi, S (Sep 2014). "Malignant transformation in craniopharyngiomas". Neurosurgery. 75 (3): 306–14, discussion 314. doi:10.1227/NEU.0000000000000380. PMID 24978859.