Jump to navigation Jump to search

WikiDoc Resources for Costamere


Most recent articles on Costamere

Most cited articles on Costamere

Review articles on Costamere

Articles on Costamere in N Eng J Med, Lancet, BMJ


Powerpoint slides on Costamere

Images of Costamere

Photos of Costamere

Podcasts & MP3s on Costamere

Videos on Costamere

Evidence Based Medicine

Cochrane Collaboration on Costamere

Bandolier on Costamere

TRIP on Costamere

Clinical Trials

Ongoing Trials on Costamere at Clinical

Trial results on Costamere

Clinical Trials on Costamere at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Costamere

NICE Guidance on Costamere


FDA on Costamere

CDC on Costamere


Books on Costamere


Costamere in the news

Be alerted to news on Costamere

News trends on Costamere


Blogs on Costamere


Definitions of Costamere

Patient Resources / Community

Patient resources on Costamere

Discussion groups on Costamere

Patient Handouts on Costamere

Directions to Hospitals Treating Costamere

Risk calculators and risk factors for Costamere

Healthcare Provider Resources

Symptoms of Costamere

Causes & Risk Factors for Costamere

Diagnostic studies for Costamere

Treatment of Costamere

Continuing Medical Education (CME)

CME Programs on Costamere


Costamere en Espanol

Costamere en Francais


Costamere in the Marketplace

Patents on Costamere

Experimental / Informatics

List of terms related to Costamere

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

The costamere or dystrophin-associated protein complex (DAPC) is a structural-functional component of skeletal muscle cells which, according to original descriptions in the early 1980s (which are generally still accepted), are sub-sarcolemmal protein assemblies circumferentially aligned in register with the Z-disk of peripheral myofibrils. They physically couple force-generating sarcomeres with the sarcolemma in striated muscle cells and are thus considered the "Achilles heel", i.e. the key vulnerable point of the muscle which is defective in many myopathies. [1]

The DAPC contains various macromolecules such as dystroglycans which are responsible for linking the DAPC to extracellular proteins; collagen and laminin for example. Therefore it is one of the features of the sarcolemma which helps to couple the sarcomere to the extracellular connective tissue. Desmin protein may also bind to the DAPC, and regions of it are known to be involved in signaling.


  1. James M. Ervasti Costameres: the Achilles' Heel of Herculean Muscle J. Biol. Chem. 278: 13591-13594.

Template:WH Template:WS