Chronic renal failure history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]

Overview

There are no pathognomonic symptoms associated with chronic renal failure. Malaise, nausea, unintentional weight loss, pruritus, lower extremity edema, and sleep disorders are common non-specific symptoms of chronic renal failure.

Personal History and Symptoms

Dermatologic

  • Pruritus

Neuromuscular

  • Anorexia
  • Fatigue
  • Nausea (especially in the morning)
  • Sleep disturbances and sleep apnea
  • Hiccups
  • Dry mouth
  • Headache
  • Reduced sense of smell and taste
  • Lower extremity cramps and edema
  • Restless legs
  • Extremity numbness, paresthesias, and weakness (sensorimotor peripheral neuropathy)
  • Seizures
  • Decreased mental acquity
  • Coma

Cardiothoracic

  • Chest pain (uremic pericarditis)

Abdominal

  • Abdominal distention (serositis)
  • Abdominal discomfort

Hematologic

  • Skin pallor
  • Bleeding tendency

Metabolic

  • Unintentional weight loss
  • Amenorrhea
  • Sexual dysfunction
    • Loss of libido
    • Impotence
  • Failure to thrive (in children)

Family History

Medications History

  • History of excessive NSAID use
  • Chronic exposure to nephrotoxic agents (e.g. heavy metals)

References

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