Chronic pain causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Cancer Pain

• Bony pain secondary to metastasis
• Postradiation mucositis or neuritis
• Visceral pain secondary to mass effects

Headache

• Cervical radiculopathy
• Cluster headache
• Migraine headache
• Temporomandibular Joint Syndrome
• Tension headache

Low Back Pain

• Facet Syndrome
• Lumbar radiculopathy
• Myofascial pain
• Spinal Stenosis

Musculoskeletal

• Ankylosing Spondylitis
• Bilateral soft tissue Rheumatism
• Dermatomyositis
• Eosinophilia myalgia syndrome
• Fibromyalgia
• Myofascial pain syndrome
• Polymyalgia
• Polymyositis
• Psychogenic rheumatism
• Reiter's Syndrome
• Repetitive strain syndromes
• Rheumatoid Arthritis
• Silicone implants
• Sjogren's Syndrome
• Soft tissue injury
• Vasculitis

Neuropathic

• Cervical radiculopathy
• Diabetic neuropathy
• Phantom limb
• Post-herpetic neuralgia
• Postoperative thoracotomy
• Reflex sympathetic dystrophy

Pelvic/Abdominal

• Endometriosis
• Fibroids
• Interstitial cystitis
• Irritable Bowel Syndrome

Psychiatric

• Anxiety
• Depression
• Emotional, physical, and/or sexual abuse
• Malingering
• Somatization

Miscellaneous

• Chronic Fatigue Syndrome
• Entrapment neuropathy
• Hypermobility
• Hyperthyroidism
• Hypophosphatemia
• Hypothyroidism
• Metabolic bone disease
• Multiple Sclerosis
• Osteomalacia
• Overuse syndromes
• Paraneoplastic syndrome
• Postviral arthralgia, myalgia

Causes by Organ System

Cardiovascular	Behcet's disease, Budd-Chiari syndrome, Buerger's disease, Cholesterol Emboli Syndrome, Cholesterol pericarditis, Chronic Stable Angina, Deep vein thrombosis, Dilated cardiomyopathy, Peripheral artery occlusive disease, Raynaud's phenomenon, Varicose veins, Vasculitis,
Chemical / poisoning	Lead poisoning,
Dermatologic	Cellulitis, Pilonidal cyst, Plantar fasciitis, Pyoderma gangrenosum,
Drug Side Effect	Opioid-induced hyperalgesia,
Ear Nose Throat	Aphthous ulcer, Otitis media, Plummer-Vinson syndrome, Sinusitis,
Endocrine	Diabetic neuropathy, Hyperthyroidism, Hypothyroidism,
Environmental	No underlying causes
Gastroenterologic	Alcoholic Hepatitis, Anal fistula, Ascending cholangitis, Autoimmune Hepatitis, Autoimmune pancreatitis, Barrett's esophagus, Celiac disease, Cholangiocarcinoma, Cholangitis, Cirrhosis, Colorectal cancer, Crohn's disease, Esophageal cancer, Fructose malabsorption, Functional bowel disorder, Fundic gland polyposis, Gallbladder cancer, Gallstone Disease, Gastroesophageal reflux disease, Hemorrhoids, Intestinal pseudoobstruction, Irritable bowel syndrome, Ischemic colitis, Peptic ulcer, Ulcerative colitis, Viral Hepatitis ,
Genetic	Cystic fibrosis, Familial dysautonomia, Hurler's Syndrome,
Hematologic	Acute intermittent porphyria, Acute myeloid leukemia, Atheroembolic disease, Erythromelagia, Leukemia, Post-thrombotic syndrome, Sickle-cell disease,
Iatrogenic	Graft-versus-host disease,
Infectious Disease	Ascaris infection, Chlamydia infection, Dientamoebiasis, Poliomyelitis,
Musculoskeletal / Ortho	Achilles tendinitis, Ankylosing Spondylitis, Baker's cyst, Carpal tunnel syndrome, Chondromalacia patellae, Degenerative disc disease, DeQuervain's syndrome, Dermatomyositis, Exostosis, Frozen Shoulder, Gout, Juvenile idiopathic arthritis, Myofascial pain syndrome, Myotonic dystrophy, Osteoarthritis, Osteochondroma, Osteomalacia, Paget's Disease, Pelvic myoneuropathy, Polymyalgia Rheumatica, Polymyositis, Reactive arthritis, Sciatica, Spinal disc herniation, Spinal Stenosis, Spondylolisthesis, Synovial osteochondromatosis, Temporomandibular Joint Syndrome, Tendinitis, Tennis elbow,
Neurologic	Alexithymia, Amyotrophic lateral sclerosis, Arachnoiditis, Cerebellar Infarction, Cervical radiculopathy, Chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, Migraine, Multiple Sclerosis, Neurofibromatosis type I, Schwannomatosis, Syringomyelia,
Nutritional / Metabolic	Beriberi, Farber disease, Gaucher's disease, Metabolic bone disease,
Obstetric/Gynecologic	Chronic pelvic pain, Endometrial cancer, Endometriosis, Pelvic inflammatory disease, Polycystic ovary syndrome,
Oncologic	Cancer Pain, Desmoplastic small round cell tumor, Multiple myeloma, Nasopharyngeal carcinoma, Lymphangiomatosis, Pancreatic cancer, Paraneoplastic syndrome, Sacrococcygeal teratoma,
Opthalmologic	Keratoconjunctivitis sicca, Tolosa-Hunt syndrome,
Overdose / Toxicity	No underlying causes
Psychiatric	Conversion disorder, Psychogenic rheumatism,
Pulmonary	Acute Chest Syndrome, Caplan's Syndrome, Chronic bronchitis, Lung abscess, Lung cancer, Malignant Mesothelioma,
Renal / Electrolyte	Gout, Hypophosphatemia, Interstitial nephritis, Pyelonephritis, Renal osteodystrophy,
Rheum / Immune / Allergy	Angioedema, Ankylosing Spondylitis, Churg-Strauss syndrome, Henoch-Schonlein purpura, Periodic fever syndrome, Reactive arthritis, Rheumatoid arthritis, Sarcoidosis, Sjogren's Syndrome, Systemic lupus erythematosus,
Sexual	Epididymitis,
Trauma	Chronic wound,
Urologic	Interstitial cystitis, Obstructive uropathy,
Miscellaneous	Anxiety, Benign fasciculation syndrome, Chronic Fatigue Syndrome, Chronic functional abdominal pain, Cluster headache,

Causes by Alphabetical Order

(In alphabetical order)

Achilles tendinitis Acute Chest Syndrome Acute intermittent porphyria Acute myeloid leukemia Alcoholic Hepatitis Alexithymia Amyotrophic lateral sclerosis Anal fistula Angina pectoris Angioedema Ankylosing Spondylitis Anxiety Aphthous ulcer Arachnoiditis Ascaris infection Ascending cholangitis Atheroembolic disease Autoimmune Hepatitis Autoimmune pancreatitis Baker's cyst Barrett's esophagus Behcet's disease Benign fasciculation syndrome Beriberi Bilateral soft tissue Rheumatism Bony pain secondary to metastasis Budd-Chiari syndrome Buerger's disease Cancer Pain Caplan's Syndrome Carpal tunnel syndrome Celiac disease Cellulitis Cerebellar Infarction Cervical radiculopathy Chlamydia infection Cholangiocarcinoma Cholangitis Cholesterol Emboli Syndrome Cholesterol pericarditis Chondromalacia patellae Chronic bronchitis Chronic Fatigue Syndrome Chronic functional abdominal pain Chronic inflammatory demyelinating polyneuropathy Chronic pelvic pain Chronic Stable Angina Chronic wound Churg-Strauss syndrome Cirrhosis Cluster headache Colorectal cancer Common variable immunodeficiency Complex regional pain syndrome Constrictive pericarditis Conversion disorder Crohn's disease Cystic fibrosis Deep vein thrombosis Degenerative disc disease Depression DeQuervain's syndrome Dermatomyositis Desmoplastic small round cell tumor Diabetic neuropathy Dientamoebiasis Dilated cardiomyopathy Endometrial cancer Endometriosis Entrapment neuropathy Eosinophilia-myalgia syndrome Epididymitis Erythromelagia Esophageal cancer Exostosis Facet Syndrome Familial dysautonomia Farber disease Fibroids Fibromyalgia Frozen Shoulder Fructose malabsorption Functional bowel disorder Fundic gland polyposis Gallbladder cancer Gallstone Disease Gastroesophageal reflux disease Gaucher's disease Gout Graft-versus-host disease Guillain-Barre syndrome Heberden's node Hemorrhoids Henoch-Schonlein purpura

Hurler's Syndrome Hypermobility Hyperthyroidism Hypophosphatemia Hypothyroidism Interstitial cystitis Interstitial nephritis Intestinal pseudoobstruction Irritable bowel syndrome Ischemic colitis Juvenile idiopathic arthritis Keratoconjunctivitis sicca Lead poisoning Leukemia Lumbar radiculopathy Lung abscess Lung cancer Lymphangiomatosis Malignant Mesothelioma Metabolic bone disease Migraine Multiple myeloma Multiple Sclerosis Myalgic encephalomyelitis Myofascial pain syndrome Myotonic dystrophy Nasopharyngeal carcinoma Neurofibromatosis type I Neuropathic Obstructive uropathy Opioid-induced hyperalgesia Orchialgia Osteoarthritis Osteochondroma Osteomalacia Otitis media Paget's Disease Pancreatic cancer Paraneoplastic syndrome Pelvic inflammatory disease Pelvic myoneuropathy Peptic ulcer Periodic fever syndrome Peripheral artery occlusive disease Phantom limb Pilonidal cyst Plantar fasciitis Plummer-Vinson syndrome Poliomyelitis Polycystic ovary syndrome Polymyalgia Polymyalgia Rheumatica Polymyositis Post-herpetic neuralgia Post-thrombotic syndrome Psychiatric Psychogenic rheumatism Pudendal nerve entrapment Pyelonephritis Pyoderma gangrenosum Raynaud's phenomenon Reactive arthritis Renal osteodystrophy Repetitive strain syndromes Rheumatoid arthritis Sacrococcygeal teratoma Sarcoidosis Schwannomatosis Sciatica Secondary hyperparathyroidism Short bowel syndrome Sickle-cell disease Sinusitis Sjogren's Syndrome Soft tissue injury Somatization Spinal disc herniation Spinal Stenosis Spondylolisthesis Synovial osteochondromatosis Syringomyelia Systemic lupus erythematosus Temporomandibular Joint Syndrome Tendinitis Tennis elbow Tension headache Tolosa-Hunt syndrome Ulcerative colitis Ulcers Varicose veins Vasculitis Vertebral subluxation Viral Hepatitis Visceral pain secondary to mass effects