Asplenia history and symptoms

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Asplenia Microchapters


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Differentiating Asplenia from other Diseases

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalpana Giri, MBBS[2]


Patients with asplenia may have a positive history of trauma, surgery, sickle cell disease, chronic liver disease, human immunodeficiency virus (HIV), malignancies, thalassemia, celiac disease, ulcerative colitis, sarcoidosis, amyloidosis, lupus, rheumatoid arthritis, mutations in RPSA, connexin 43 and ZIC3. Common symptoms include chills, sore throat, diarrhea, muscle aches, abdominal pain, nausea and vomiting, neck stiffness, altered mental status. Less common symptoms include cyanosis, respiratory distress.

History and Symptoms


Patients with asplenia may have a positive history of:

Common Symptoms

Common symptoms of asplenia include:

Less Common Symptoms


  1. Ahmed SA, Zengeya S, Kini U, Pollard AJ (2010). "Familial isolated congenital asplenia: case report and literature review". Eur J Pediatr. 169 (3): 315–8. doi:10.1007/s00431-009-1030-0. PMID 19618213.
  2. 2.0 2.1 2.2 Thiruppathy K, Privitera A, Jain K, Gupta S (2008). "Congenital asplenia and group B streptococcus sepsis in the adult: case report and review of the literature". FEMS Immunol Med Microbiol. 53 (3): 437–9. doi:10.1111/j.1574-695X.2008.00422.x. PMID 18564289.
  3. Long B, Koyfman A, Gottlieb M (2021). "Complications in the adult asplenic patient: A review for the emergency clinician". Am J Emerg Med. 44: 452–457. doi:10.1016/j.ajem.2020.03.049. PMID 32247651 Check |pmid= value (help).
  4. MYERSON RM, KOELLE WA (1956). "Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome". N Engl J Med. 254 (24): 1131–2. doi:10.1056/NEJM195606142542406. PMID 13322226.
  5. Yildiz H, Yombi JC (2017). "Fever and asplenia: a dangerous association". BMJ Case Rep. 2017. doi:10.1136/bcr-2017-220513. PMC 5535142. PMID 28659372.
  6. Huebner ML, Milota KA (2015). "Asplenia and fever". Proc (Bayl Univ Med Cent). 28 (3): 340–1. doi:10.1080/08998280.2015.11929267. PMC 4462215. PMID 26130882.

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