Amanullin

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Template:Chembox E numberTemplate:Chembox SolubilityInWater
Amanullin
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Names
Other names
3-Isoleucine-alpha-amanitin
Identifiers
3D model (JSmol)
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Properties
C39H54N10O12S
Molar mass 886.86 g/mol
Appearance Colorless, crystalline solid
Solubility in ethanol, methanol Soluble
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral Template:LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.

Toxicology

Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

References

  1. Cochet-Meilhac M, Chambon P (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. PMID 4601749. Unknown parameter |month= ignored (help)

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