epsilon-amanitin

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ε-Amanitin
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Names
Other names
Amanine
Identifiers
3D model (JSmol)
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Properties
C39H53N9O14S
Molar mass 903.96 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

epsilon-Amanitin or ε-amanitin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral of ε-Amanitin is approximately 0.1 mg/kg.

Toxicology

Like other amatoxins, ε-amanitin an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]

References

  1. M. Cochet-Meillhac and Chambon P. (1974). Biochim Biophys Acta. 353: 160–184 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~ZI8h7t:1. Missing or empty |title= (help)

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