Waldenström's macroglobulinemia: Difference between revisions

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#Intertrabecular pattern of bone marrow infiltration.
#Intertrabecular pattern of bone marrow infiltration.
#Surface IgM+, CD5±, CD10−, CD19+, CD20+, CD22+, CD23−, CD25+, CD27+, FMC7+, CD103−, CD138 immunophenotype.
#Surface IgM+, CD5±, CD10−, CD19+, CD20+, CD22+, CD23−, CD25+, CD27+, FMC7+, CD103−, CD138 immunophenotype.
(3,4 are supportive of but not necessary for WM diagnosis).
*Not all the diagnostic tests mentioned are performed in a WM patient. A doctor takes into account the following factors before choosing diagnostic tests in a particular patient:
*Not all the diagnostic tests mentioned are performed in a WM patient. A doctor takes into account the following factors before choosing diagnostic tests in a particular patient:
**Suspected type of cancer.
**Suspected type of cancer.

Revision as of 16:55, 6 February 2019

Waldenström's macroglobulinemia Microchapters

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For patient information on this page, click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Roukoz A. Karam, M.D.[3], Mirdula Sharma, MBBS [4]

Synonyms and keywords: Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary macroglobulinemia, Lymphoplasmacytic lymphoma (LPL), Plasmacytoid lymphocytic lymphoma, Familial Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Waldenström's Macroglobulinemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic criteria of Waldenstrom Macroglobulinemia

In September 26-30, 2002, in Athens, Greece,the Second International Workshop was held in which the following diagnostic criteria for Waldenstrom's Macroglobulinemia was proposed:

  1. IgM monoclonal protein of any concentration.
  2. Bone marrow infiltration by small lymphocytes showing plasmacytoid/plasma-cell differentiation.
  3. Intertrabecular pattern of bone marrow infiltration.
  4. Surface IgM+, CD5±, CD10−, CD19+, CD20+, CD22+, CD23−, CD25+, CD27+, FMC7+, CD103−, CD138 immunophenotype.

(3,4 are supportive of but not necessary for WM diagnosis).

  • Not all the diagnostic tests mentioned are performed in a WM patient. A doctor takes into account the following factors before choosing diagnostic tests in a particular patient:
    • Suspected type of cancer.
    • Signs and symptoms.
    • Age.
    • Medical condition of the patient.
    • Results of earlier medical tests.

Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Electrocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1



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