Plasma cell disorder: Difference between revisions

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== [[Plasma cell disorder| Differential Diagnosis]] ==
==[[Plasma cell disorder| Differential Diagnosis]]==
{| class="wikitable"
{| class="wikitable"
|+
|+
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| style="background:#F5F5F5;" align="center" + |<10%
| style="background:#F5F5F5;" align="center" + |<10%
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* No end-organ damage
*No end-organ damage
|-
|-
| style="background:#DCDCDC;" align="center" + |Smoldering MM
| style="background:#DCDCDC;" align="center" + |Smoldering MM
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| style="background:#F5F5F5;" align="center" + |10-60%
| style="background:#F5F5F5;" align="center" + |10-60%
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* No myeloma-defining event  
*No myeloma-defining event
* No  CRAB features
*No  CRAB features
|-
|-
| style="background:#DCDCDC;" align="center" + |[[Monoclonal gammopathy of undetermined significance|Light chain MGUS]]
| style="background:#DCDCDC;" align="center" + |[[Monoclonal gammopathy of undetermined significance|Light chain MGUS]]
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| style="background:#F5F5F5;" align="center" + |<10%
| style="background:#F5F5F5;" align="center" + |<10%
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* No end-organ damage
*No end-organ damage
|-
|-
| style="background:#DCDCDC;" align="center" + |[[Multiple myeloma classification|Active symptomatic Multiple myeloma]]
| style="background:#DCDCDC;" align="center" + |[[Multiple myeloma classification|Active symptomatic Multiple myeloma]]
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| style="background:#F5F5F5;" align="center" + |>60%
| style="background:#F5F5F5;" align="center" + |>60%
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* ≥1 myeloma-defining event
*≥1 myeloma-defining event
* CRAB features
*CRAB features
|-
|-
| style="background:#DCDCDC;" align="center" + |[[Waldenström's macroglobulinemia|Waldenstrom macroglobulinemia]]
| style="background:#DCDCDC;" align="center" + |[[Waldenström's macroglobulinemia|Waldenstrom macroglobulinemia]]
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| style="background:#F5F5F5;" align="center" + |>10%
| style="background:#F5F5F5;" align="center" + |>10%
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* Evidence of organ/tissue damage
*Evidence of organ/tissue damage
* [[Anemia]]
*[[Anemia]]
* [[Hepatosplenomegaly]]
*[[Hepatosplenomegaly]]
|-
|-
| style="background:#DCDCDC;" align="center" + |Solitary Plasmacytoma
| style="background:#DCDCDC;" align="center" + |Solitary Plasmacytoma
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| style="background:#F5F5F5;" align="center" + |<3mg/dl
| style="background:#F5F5F5;" align="center" + |<3mg/dl
| style="background:#F5F5F5;" align="center" + |Abnormal in 47% cases
| style="background:#F5F5F5;" align="center" + |Abnormal in 47% cases
| style="background:#F5F5F5;" align="center" + |Normal  
| style="background:#F5F5F5;" align="center" + |Normal
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* Solitory bone lesion due to [[plasma cell]] tumor
*Solitory bone lesion due to [[plasma cell]] tumor
* Preserved levels of uninvolved [[immunoglobulins]]
*Preserved levels of uninvolved [[immunoglobulins]]
* No [[anemia]], [[hypercalcemia]] or [[renal disease]]
*No [[anemia]], [[hypercalcemia]] or [[renal disease]]
|-
|-
| style="background:#DCDCDC;" align="center" + |[[AL amyloidosis|Primary amyloidosis]]
| style="background:#DCDCDC;" align="center" + |[[AL amyloidosis|Primary amyloidosis]]
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| style="background:#F5F5F5;" align="center" + |−
| style="background:#F5F5F5;" align="center" + |−
| style="background:#F5F5F5;" align="center" + |<3md/dl
| style="background:#F5F5F5;" align="center" + |<3md/dl
| style="background:#F5F5F5;" align="center" + |[[Light chain|Light chains]] of [[Immunoglobulin|immunoglobulines]]  
| style="background:#F5F5F5;" align="center" + |[[Light chain|Light chains]] of [[Immunoglobulin|immunoglobulines]]
| style="background:#F5F5F5;" align="center" + |<10%
| style="background:#F5F5F5;" align="center" + |<10%
| style="background:#F5F5F5;" align="left" + |
| style="background:#F5F5F5;" align="left" + |
* No bone lesions
*No bone lesions
* [[Nephrotic syndrome]]
*[[Nephrotic syndrome]]
* [[Restrictive cardiomyopathy]]
*[[Restrictive cardiomyopathy]]
* [[Peripheral neuropathy]]
*[[Peripheral neuropathy]]
* [[Hepatomegaly]] with elevated [[liver enzymes]]
*[[Hepatomegaly]] with elevated [[liver enzymes]]
* [[Macroglossia]]
*[[Macroglossia]]
* [[Purpura]] and an unexplained [[Hemorrhagic diathesis|bleeding diathesis]]
*[[Purpura]] and an unexplained [[Hemorrhagic diathesis|bleeding diathesis]]
|-
|-
| colspan="10" style="background:#DCDCDC;" align="left" + |
| colspan="10" style="background:#DCDCDC;" align="left" + |
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|}
|}


== Monoclonal gammopathies of undetermined significance (MGUS) ==
==Monoclonal gammopathies of undetermined significance (MGUS)==
* [[Monoclonal gammopathy of undetermined significance]] is a condition in which a low or non-quantifiable level of a [[monoclonal]] [[paraprotein]] is detected in the blood by means of [[protein electrophoresis]].<ref name="pmid16628189">{{cite journal |vauthors=Jego G, Bataille R, Geffroy-Luseau A, Descamps G, Pellat-Deceunynck C |title=Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors |journal=Leukemia |volume=20 |issue=6 |pages=1130–7 |date=June 2006 |pmid=16628189 |doi=10.1038/sj.leu.2404226 |url=}}</ref><ref name="pmid19181642">{{cite journal |vauthors=Dinarello CA |title=Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease |journal=Mayo Clin. Proc. |volume=84 |issue=2 |pages=105–7 |date=February 2009 |pmid=19181642 |pmc=2664579 |doi=10.4065/84.2.105 |url=}}</ref><ref name="pmid23233640">{{cite journal |vauthors=Merlini G, Palladini G |title=Differential diagnosis of monoclonal gammopathy of undetermined significance |journal=Hematology Am Soc Hematol Educ Program |volume=2012 |issue= |pages=595–603 |date=2012 |pmid=23233640 |doi=10.1182/asheducation-2012.1.595 |url=}}</ref>
 
*[[Monoclonal gammopathy of undetermined significance]] is a condition in which a low or non-quantifiable level of a [[monoclonal]] [[paraprotein]] is detected in the blood by means of [[protein electrophoresis]].<ref name="pmid16628189">{{cite journal |vauthors=Jego G, Bataille R, Geffroy-Luseau A, Descamps G, Pellat-Deceunynck C |title=Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors |journal=Leukemia |volume=20 |issue=6 |pages=1130–7 |date=June 2006 |pmid=16628189 |doi=10.1038/sj.leu.2404226 |url=}}</ref><ref name="pmid19181642">{{cite journal |vauthors=Dinarello CA |title=Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease |journal=Mayo Clin. Proc. |volume=84 |issue=2 |pages=105–7 |date=February 2009 |pmid=19181642 |pmc=2664579 |doi=10.4065/84.2.105 |url=}}</ref><ref name="pmid23233640">{{cite journal |vauthors=Merlini G, Palladini G |title=Differential diagnosis of monoclonal gammopathy of undetermined significance |journal=Hematology Am Soc Hematol Educ Program |volume=2012 |issue= |pages=595–603 |date=2012 |pmid=23233640 |doi=10.1182/asheducation-2012.1.595 |url=}}</ref>
*<nowiki/>In addition, some patients develop a [[polyneuropathy]]<nowiki/> or other problems related to the secreted antibody.
*<nowiki/>In addition, some patients develop a [[polyneuropathy]]<nowiki/> or other problems related to the secreted antibody.
* MGUS is a premalignant condition and is distinct fr<nowiki/>om [[multiple myeloma]].
*MGUS is a premalignant condition and is distinct fr<nowiki/>om [[multiple myeloma]].
* Pathologically, the lesion in [[Monoclonal gammopathy of undetermined significance]] is in fact very similar to that in [[multiple myeloma]].
*Pathologically, the lesion in [[Monoclonal gammopathy of undetermined significance]] is in fact very similar to that in [[multiple myeloma]].
For more information about Monoclonal gammopathies of undetermined significance  '''[[Monoclonal gammopathies of undetermined significance |click here]].'''
 
For more information about monoclonal gammopathies of undetermined significance  '''[[Monoclonal gammopathies of undetermined significance |click here]].'''
 
==Malignant monoclonal gammopathies==
 
==='''Multiple myeloma'''===
 
====Symptomatic multiple myeloma====
 
*People with [[Multiple myeloma classification|multiple myeloma]] with symptoms are categorized to have [[Multiple myeloma Classification|active multiple myeloma]] and will exhibit any of the following features:<ref name="SergentanisZagouri2015">{{cite journal|last1=Sergentanis|first1=Theodoros N.|last2=Zagouri|first2=Flora|last3=Tsilimidos|first3=Gerasimos|last4=Tsagianni|first4=Anastasia|last5=Tseliou|first5=Melina|last6=Dimopoulos|first6=Meletios A.|last7=Psaltopoulou|first7=Theodora|title=Risk Factors for Multiple Myeloma: A Systematic Review of Meta-Analyses|journal=Clinical Lymphoma Myeloma and Leukemia|volume=15|issue=10|year=2015|pages=563–577.e3|issn=21522650|doi=10.1016/j.clml.2015.06.003}}</ref>
**[[M protein]] in blood or urine
**[[Bone marrow cells|Bone marrow]] [[plasma cells]] constitute more than 10% of the [[blood cells]]
**Presence of solitary [[plasmacytoma]] in bone
**≥ 1 myeloma-defining event
**CRAB features ( explained above)
**Osteolytic lesions on bone x-ray
 
*Patients with active [[multiple myeloma]] usually require treatment to prevent progression of disease which can lead to death.
 
====Smoldering multiple myeloma====


== Malignant monoclonal gammopathies ==
*It is asymptomatic type of [[Multiple myeloma classification|multiple myeloma]].<ref name="pmid27291302">{{cite journal |vauthors=Rajkumar SV |title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=91 |issue=7 |pages=719–34 |date=July 2016 |pmid=27291302 |pmc=5291298 |doi=10.1002/ajh.24402 |url=}}</ref>
*Shows presence of M-spike that quantitates > 3 g/dl on [[protein electrophoresis]].


=== '''Multiple myeloma''' ===
*Presence of [[Bone marrow cells|bone marrow plasma cell]] burden of > 10% but < 60%.


==== Symptomatic multiple myeloma ====
*Absence of end-organ damage such as [[anemia]], [[hypercalcemia]], [[Renal dysfunction|renal dysfunction,]] or [[Osseous|osseous lesions]].
* People with [[Multiple myeloma classification|multiple myeloma]] with symptoms are categorized to have [[Multiple myeloma Classification|active multiple myeloma]] and will exhibit any of the following features:<ref name="SergentanisZagouri2015">{{cite journal|last1=Sergentanis|first1=Theodoros N.|last2=Zagouri|first2=Flora|last3=Tsilimidos|first3=Gerasimos|last4=Tsagianni|first4=Anastasia|last5=Tseliou|first5=Melina|last6=Dimopoulos|first6=Meletios A.|last7=Psaltopoulou|first7=Theodora|title=Risk Factors for Multiple Myeloma: A Systematic Review of Meta-Analyses|journal=Clinical Lymphoma Myeloma and Leukemia|volume=15|issue=10|year=2015|pages=563–577.e3|issn=21522650|doi=10.1016/j.clml.2015.06.003}}</ref>
** [[M protein]] in blood or urine
** [[Bone marrow cells|Bone marrow]] [[plasma cells]] constitute more than 10% of the [[blood cells]]
** Presence of solitary [[plasmacytoma]] in bone
** ≥ 1 myeloma-defining event
** CRAB features ( explained above)
** Osteolytic lesions on bone x-ray


* Patients with active [[multiple myeloma]] usually require treatment to prevent progression of disease which can lead to death.
*Patients with smoldering (asymptomatic) [[multiple myeloma]] are managed by observation and undergoing follow up tests every 3 to 6 months.
*There is high risk of developing active [[multiple myeloma]].


==== Smoldering multiple myeloma ====
====Plasma-cell leukemia====
* It is asymptomatic type of [[Multiple myeloma classification|multiple myeloma]].<ref name="pmid27291302">{{cite journal |vauthors=Rajkumar SV |title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=91 |issue=7 |pages=719–34 |date=July 2016 |pmid=27291302 |pmc=5291298 |doi=10.1002/ajh.24402 |url=}}</ref>
* Shows presence of M-spike that quantitates > 3 g/dl on [[protein electrophoresis]].


* Presence of [[Bone marrow cells|bone marrow plasma cell]] burden of > 10% but < 60%.
*Characterized by large number of [[plasma cells]] circulating in the blood.<ref name="Rajkumar2016" />
*Rare condition, can develop in to most aggressive form of [[Multiple myeloma Classification|multiple myeloma]].
*Can occur as a secondary type in a patient with multiple myeloma.
*Treatment options for [[plasma cell leukemia]] is [[chemotherapy]] or [[Hematopoietic stem cell transplantation|stem cell transplant]].


* Absence of end-organ damage such as [[anemia]], [[hypercalcemia]], [[Renal dysfunction|renal dysfunction,]] or [[Osseous|osseous lesions]].
====Non-secretory myeloma====


* Patients with smoldering (asymptomatic) [[multiple myeloma]] are managed by observation and undergoing follow up tests every 3 to 6 months.
*Type of [[Multiple myeloma classification|multiple myeloma]] with less amount of [[M protein|M proteins]] secretion in [[blood]] or urine.<ref name="Rajkumar2016" />
* There is high risk of developing active [[multiple myeloma]].
*M protein is not detected by [[serum protein electrophoresis]].
*[[Bone marrow]] exibit [[Myeloma|myeloma cells]].
*Osteolytic bone lesions are seen on X-ray.


==== Plasma-cell leukemia ====
====IgD myeloma====
* Characterized by large number of [[plasma cells]] circulating in the blood.<ref name="Rajkumar2016" />
* Rare condition, can develop in to most aggressive form of [[Multiple myeloma Classification|multiple myeloma]].
* Treatment options for [[plasma cell leukemia]] is [[chemotherapy]] or [[Hematopoietic stem cell transplantation|stem cell transplant]].


==== Non-secretory myeloma ====
*IgD type constitues 2% of [[Multiple myeloma Classification|multiple myeloma]].<ref name="Rajkumar2016" />
* Type of [[Multiple myeloma classification|multiple myeloma]] with less amount of [[M protein|M proteins]] secretion in [[blood]] or urine.<ref name="Rajkumar2016" />
*IgD [[Multiple myeloma classification|multiple myeloma]] has similar signs and symptoms as other types of [[Multiple myeloma classification|multiple myeloma]].
* M protein is not detected by [[serum protein electrophoresis]].
* [[Bone marrow]] exibit [[Myeloma|myeloma cells]].
* Osteolytic bone lesions are seen on X-ray.


==== IgD myeloma ====
*IgD myeloma mostly affect people of younger age.
* IgD type constitues 2% of [[Multiple myeloma Classification|multiple myeloma]].<ref name="Rajkumar2016" />
* IgD [[Multiple myeloma classification|multiple myeloma]] has similar signs and symptoms as other types of [[Multiple myeloma classification|multiple myeloma]].


* IgD myeloma mostly affect people of younger age.
====Osteosclerotic myeloma====


==== Osteosclerotic myeloma ====
*It is a rare disorder affecting multiple systems of the body.<ref name="Rajkumar2016">{{cite journal|last1=Rajkumar|first1=S. Vincent|title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management|journal=American Journal of Hematology|volume=91|issue=7|year=2016|pages=719–734|issn=03618609|doi=10.1002/ajh.24402}}</ref>
* It is a rare disorder affecting multiple systems of the body.<ref name="Rajkumar2016">{{cite journal|last1=Rajkumar|first1=S. Vincent|title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management|journal=American Journal of Hematology|volume=91|issue=7|year=2016|pages=719–734|issn=03618609|doi=10.1002/ajh.24402}}</ref>


* It is called POEMS syndrome: [[polyneuropathy]], [[Organomegaly|organomegaly,]] [[endocrinopathy]], monoclonal protein, skin changes.
*It is called POEMS syndrome: [[polyneuropathy]], [[Organomegaly|organomegaly,]] [[endocrinopathy]], monoclonal protein, skin changes.
* Treatment option for osteoclastic myeloma include:
*Treatment option for osteoclastic myeloma include:
** [[Chemotherapy]]
**[[Chemotherapy]]
** [[Radiation therapy]]
**[[Radiation therapy]]
** [[Hematopoietic stem cell transplantation|Stem cell transplant]]
**[[Hematopoietic stem cell transplantation|Stem cell transplant]]


==== Solitary plasmacytoma of bone ====
====Solitary plasmacytoma of bone====
* [[Plasmacytoma]] is collection of abnormal [[plasma cells]] forming a single tumor.<ref name="CaersPaiva2018">{{cite journal|last1=Caers|first1=J.|last2=Paiva|first2=B.|last3=Zamagni|first3=E.|last4=Leleu|first4=X.|last5=Bladé|first5=J.|last6=Kristinsson|first6=S. Y.|last7=Touzeau|first7=C.|last8=Abildgaard|first8=N.|last9=Terpos|first9=E.|last10=Heusschen|first10=R.|last11=Ocio|first11=E.|last12=Delforge|first12=M.|last13=Sezer|first13=O.|last14=Beksac|first14=M.|last15=Ludwig|first15=H.|last16=Merlini|first16=G.|last17=Moreau|first17=P.|last18=Zweegman|first18=S.|last19=Engelhardt|first19=M.|last20=Rosiñol|first20=L.|title=Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel|journal=Journal of Hematology & Oncology|volume=11|issue=1|year=2018|issn=1756-8722|doi=10.1186/s13045-017-0549-1}}</ref>
 
* [[Plasmacytoma|Solitary plasmacytoma]] is occurrence of single bone [[tumor]] made up of myeloma cells.
*[[Plasmacytoma]] is collection of abnormal [[plasma cells]] forming a single tumor.<ref name="CaersPaiva2018">{{cite journal|last1=Caers|first1=J.|last2=Paiva|first2=B.|last3=Zamagni|first3=E.|last4=Leleu|first4=X.|last5=Bladé|first5=J.|last6=Kristinsson|first6=S. Y.|last7=Touzeau|first7=C.|last8=Abildgaard|first8=N.|last9=Terpos|first9=E.|last10=Heusschen|first10=R.|last11=Ocio|first11=E.|last12=Delforge|first12=M.|last13=Sezer|first13=O.|last14=Beksac|first14=M.|last15=Ludwig|first15=H.|last16=Merlini|first16=G.|last17=Moreau|first17=P.|last18=Zweegman|first18=S.|last19=Engelhardt|first19=M.|last20=Rosiñol|first20=L.|title=Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel|journal=Journal of Hematology & Oncology|volume=11|issue=1|year=2018|issn=1756-8722|doi=10.1186/s13045-017-0549-1}}</ref>
* Xray shows an osteolytic lesion at the site of the [[Tumor|tumor.]]
*[[Plasmacytoma|Solitary plasmacytoma]] is occurrence of single bone [[tumor]] made up of myeloma cells.
* [[Bone marrow]] plasma population remains less than 10%.
*X-ray shows an osteolytic lesion at the site of the [[Tumor|tumor.]]
* One third of patients with solitary [[plasmacytoma]] will develop [[Multiple myeloma classification|multiple myeloma]].
*[[Bone marrow]] plasma population remains less than 10%.
*One third of patients with solitary [[plasmacytoma]] will develop [[Multiple myeloma classification|multiple myeloma]].
 
====Extramedullary plasmacytoma====
 
*It is developed outside the [[bone marrow]] in soft tissues of the body<ref name="Rajkumar2016" />
*Most commonly seen in throat, [[paranasal sinuses]], [[nasal cavity]], [[larynx]], [[Gastrointestinal tract|GI tract,]] [[breast]], and [[brain]].
*Diagnosis is confirmed by [[biopsy]] of the [[Tumor|tumor.]]
*X-rays and [[bone marrow]] [[biopsy]] is normal.
*Treatment is done with either [[radiation therapy]] or surgery.


==== Extramedullary plasmacytoma ====
* It is developed outside the [[bone marrow]] in soft tissues of the body<ref name="Rajkumar2016" />
* Most commonly seen in throat, [[paranasal sinuses]], [[nasal cavity]], [[larynx]], [[Gastrointestinal tract|GI tract,]] [[breast]], and [[brain]].
* Diagnosis is confirmed by [[biopsy]] of the [[Tumor|tumor.]]
* X-rays and [[bone marrow]] [[biopsy]] is normal.
* Treatment is done with either [[radiation therapy]] or surgery.
For more information about [[multiple myeloma]], '''[[Multiple myeloma |click here]].'''
For more information about [[multiple myeloma]], '''[[Multiple myeloma |click here]].'''


=== Malignant lymphoproliferative disorders ===
===Malignant lymphoproliferative disorders===
==== Waldenstrom macroglobulinemia ====
====Waldenstrom macroglobulinemia====
* [[Waldenström's macroglobulinemia|Waldenstrom macroglobulinemia]] is a cancer involving [[lymphocytes]].<ref name="pmid22773606">{{cite journal |vauthors=Braggio E, Philipsborn C, Novak A, Hodge L, Ansell S, Fonseca R |title=Molecular pathogenesis of Waldenstrom's macroglobulinemia |journal=Haematologica |volume=97 |issue=9 |pages=1281–90 |date=September 2012 |pmid=22773606 |pmc=3436227 |doi=10.3324/haematol.2012.068478 |url=}}</ref>  
 
* The main attributing [[antibody]] is [[IgM]].
*[[Waldenström's macroglobulinemia|Waldenstrom macroglobulinemia]] is a cancer involving [[lymphocytes]].<ref name="pmid22773606">{{cite journal |vauthors=Braggio E, Philipsborn C, Novak A, Hodge L, Ansell S, Fonseca R |title=Molecular pathogenesis of Waldenstrom's macroglobulinemia |journal=Haematologica |volume=97 |issue=9 |pages=1281–90 |date=September 2012 |pmid=22773606 |pmc=3436227 |doi=10.3324/haematol.2012.068478 |url=}}</ref>
* It is a type of [[lymphoproliferative disease]].
*The main attributing [[antibody]] is [[IgM]].
* It shares clinical characteristics with the indolent [[Non-Hodgkin lymphoma|non-Hodgkin lymphomas]].
*It is a type of [[lymphoproliferative disease]].
* [[Waldenström's macroglobulinemia|Waldenstrom macroglobulinemia]] represents 1% of all hematological cancers.
*It shares clinical characteristics with the indolent [[Non-Hodgkin lymphoma|non-Hodgkin lymphomas]].
* Common causes of [[Waldenström's macroglobulinemia]] include [[genetic]], environmental, and [[autoimmune]] factors.
*[[Waldenström's macroglobulinemia|Waldenstrom macroglobulinemia]] represents 1% of all hematological cancers.
* Common [[risk factors]] in the development of [[Waldenström's macroglobulinemia]] are [[monoclonal gammopathies of undetermined significance]].  
*Common causes of [[Waldenström's macroglobulinemia]] include [[genetic]], environmental, and [[autoimmune]] factors.
*Common [[risk factors]] in the development of [[Waldenström's macroglobulinemia]] are [[monoclonal gammopathies of undetermined significance]].
 
For more information about [[Waldenström's macroglobulinemia]], '''[[Waldenström's macroglobulinemia |click here]].'''
For more information about [[Waldenström's macroglobulinemia]], '''[[Waldenström's macroglobulinemia |click here]].'''


==== Malignant lymphoma ====
====Malignant lymphoma====
* Type of [[cancer]] that originates in [[Lymphocyte|lymphocytes]].<ref name="isbn92-832-2411-6">{{cite book |author= |title=Pathology and Genetics of Haemo (World Health Organization Classification of Tumours S.) |publisher=Oxford Univ Pr |location= |year= |pages= |isbn=92-832-2411-6 |oclc= |doi=}}</ref>
 
* Also called [[Hematological malignancy|hematological neoplasms]].  
*Type of [[cancer]] that originates in [[Lymphocyte|lymphocytes]].<ref name="isbn92-832-2411-6">{{cite book |author= |title=Pathology and Genetics of Haemo (World Health Organization Classification of Tumours S.) |publisher=Oxford Univ Pr |location= |year= |pages= |isbn=92-832-2411-6 |oclc= |doi=}}</ref>
* Primary types include [[Hodgkin lymphoma]] and [[non-Hodgkin lymphoma]].
*Also called [[Hematological malignancy|hematological neoplasms]].
*Primary types include [[Hodgkin lymphoma]] and [[non-Hodgkin lymphoma]].
 
For more information about [[malignant lymphoma]], '''[[lymphoma |click here]].'''
For more information about [[malignant lymphoma]], '''[[lymphoma |click here]].'''


=== Chronic lymphocytic leukemia ===
===Chronic lymphocytic leukemia===
* [[Chronic lymphocytic leukemia]] arises from pre-follicular center [[B cell|B cells]], normally involved in [[Immunoglobulin|immunoglobulins]] production.<ref name="Hallek2015">{{cite journal|last1=Hallek|first1=Michael|title=Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment|journal=American Journal of Hematology|volume=90|issue=5|year=2015|pages=446–460|issn=03618609|doi=10.1002/ajh.23979}}</ref>  
 
* Development of [[chronic lymphocytic leukemia]] is the result of multiple [[Genetic mutation|genetic mutations]] that promote both [[malignant]] leukemic proliferation and [[apoptotic]] resistance of mature [[B cells]].
*[[Chronic lymphocytic leukemia]] arises from pre-follicular center [[B cell|B cells]], normally involved in [[Immunoglobulin|immunoglobulins]] production.<ref name="Hallek2015">{{cite journal|last1=Hallek|first1=Michael|title=Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment|journal=American Journal of Hematology|volume=90|issue=5|year=2015|pages=446–460|issn=03618609|doi=10.1002/ajh.23979}}</ref>
* [[Chronic lymphocytic leukemia]] must be differentiated from [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
*Development of [[chronic lymphocytic leukemia]] is the result of multiple [[Genetic mutation|genetic mutations]] that promote both [[malignant]] leukemic proliferation and [[apoptotic]] resistance of mature [[B cells]].
* [[Prognosis]] is generally good, and the 5-year survival rate of patients with [[chronic lymphocytic leukemia]] is approximately 81.7%.
*[[Chronic lymphocytic leukemia]] must be differentiated from [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
* The mainstay of therapy for [[symptomatic]] [[chronic lymphocytic leukemia]] patients is immunochemotherapy.
*[[Prognosis]] is generally good, and the 5-year survival rate of patients with [[chronic lymphocytic leukemia]] is approximately 81.7%.
*The mainstay of therapy for [[symptomatic]] [[chronic lymphocytic leukemia]] patients is immunochemotherapy.
 
For more information about [[chronic lymphocytic leukemia]], '''[[ chronic lymphocytic leukemia|click here]]'''
For more information about [[chronic lymphocytic leukemia]], '''[[ chronic lymphocytic leukemia|click here]]'''


== Heavy-chain diseases (HCD) ==
==Heavy-chain diseases (HCD)==
* Heavy chain diseases are [[plasma cell]] [[neoplasia]] featuring overproduction of [[Immunoglobulin|immunoglobulin heavy chains]].<ref name="MunshiCabot2008">{{cite journal|last1=Munshi|first1=Nikhil C.|last2=Cabot|first2=Richard C.|last3=Harris|first3=Nancy Lee|last4=Shepard|first4=Jo-Anne O.|last5=Rosenberg|first5=Eric S.|last6=Cort|first6=Alice M.|last7=Ebeling|first7=Sally H.|last8=Peters|first8=Christine C.|last9=Digumarthy|first9=Subba|last10=Rahemtullah|first10=Aliyah|title=Case 13-2008|journal=New England Journal of Medicine|volume=358|issue=17|year=2008|pages=1838–1848|issn=0028-4793|doi=10.1056/NEJMcpc0800959}}</ref>


=== γHCD ===
*Heavy chain diseases are [[plasma cell]] [[neoplasia]] featuring overproduction of [[Immunoglobulin|immunoglobulin heavy chains]].<ref name="MunshiCabot2008">{{cite journal|last1=Munshi|first1=Nikhil C.|last2=Cabot|first2=Richard C.|last3=Harris|first3=Nancy Lee|last4=Shepard|first4=Jo-Anne O.|last5=Rosenberg|first5=Eric S.|last6=Cort|first6=Alice M.|last7=Ebeling|first7=Sally H.|last8=Peters|first8=Christine C.|last9=Digumarthy|first9=Subba|last10=Rahemtullah|first10=Aliyah|title=Case 13-2008|journal=New England Journal of Medicine|volume=358|issue=17|year=2008|pages=1838–1848|issn=0028-4793|doi=10.1056/NEJMcpc0800959}}</ref>
* Also known as gamma chain or IgG heavy chain disease.
** Primarily seen in elderly men but can occur in children.
** High levels of IgG with reduction of normal [[immunoglobulin]] level.
** [[Lymphadenopathy|Lymphadenopath]]<nowiki/>y, [[hepatosplenomegaly]], and recurrent infections are common features.
** [[Vincristine]], [[Corticosteroid|corticosteroids]] and [[radiation therapy]] may produce [[Remission (medicine)|remission]].


=== αHCD ===
===γHCD===
* Also known as alpha chain or IgA heavy chain.
** Appears between age 10-30 as an [[immune]] response to a [[microorganism]].
** Patients present with diffuse abdominal [[lymphoma]] and [[malabsorption]].
** Course is variable, some patients die in 1-2 yrs, others go in to [[Remission (medicine)|remission]] lasting for many years.
** [[Serum protein electrophoresis]] detect increased α & β fraction.
** Treatment is [[Corticosteroid|corticosteroids]], [[cytotoxic drugs]] and broadspectrum antibiotics


=== μHCD ===
*Also known as gamma chain or IgG heavy chain disease.
* Also known as mu chain or IGM heavy chain disease.  
**Primarily seen in elderly men but can occur in children.
** Mainly affects individuals > 50 yrs.
**High levels of IgG with reduction of normal [[immunoglobulin]] level.
** [[Spleen]], [[liver]] and abdominal [[lymph nodes]] involvement is more common than peripheral [[lymphadenopathy]].
**[[Lymphadenopathy|Lymphadenopath]]<nowiki/>y, [[hepatosplenomegaly]], and recurrent infections are common features.
** [[Serum]] [[protein electrophoresis]] exibit [[hypogammaglobulinemia]].
**[[Vincristine]], [[Corticosteroid|corticosteroids]] and [[radiation therapy]] may produce [[Remission (medicine)|remission]].
** Vacuolated [[Plasma cell|plasma cells]] are pathognomic on [[bone marrow]] exam.
 
** Treatment consists of [[Alkylating agent|alkylating agents]] and [[Corticosteroid|corticosteroids]].
===αHCD===
 
*Also known as alpha chain or IgA heavy chain.
**Appears between age 10-30 as an [[immune]] response to a [[microorganism]].
**Patients present with diffuse abdominal [[lymphoma]] and [[malabsorption]].
**Course is variable, some patients die in 1-2 yrs, others go in to [[Remission (medicine)|remission]] lasting for many years.
**[[Serum protein electrophoresis]] detect increased α & β fraction.
**Treatment is [[Corticosteroid|corticosteroids]], [[cytotoxic drugs]] and broadspectrum antibiotics
 
===μHCD===
 
*Also known as mu chain or IGM heavy chain disease.  
**Mainly affects individuals > 50 yrs.
**[[Spleen]], [[liver]] and abdominal [[lymph nodes]] involvement is more common than peripheral [[lymphadenopathy]].
**[[Serum]] [[protein electrophoresis]] exibit [[hypogammaglobulinemia]].
**Vacuolated [[Plasma cell|plasma cells]] are pathognomic on [[bone marrow]] exam.
**Treatment consists of [[Alkylating agent|alkylating agents]] and [[Corticosteroid|corticosteroids]].
 
==Cryoglobulinemia==
 
*[[Cryoglobulinemia]] is the presence of high amount of heavy [[Globulin|globulins]] (e.g. [[IgM]]) in the [[bloodstream]] which thicken on exposure to cold.<ref name="pmid16026843">{{cite journal| author=Scotto G, Cibelli DC, Saracino A, Prato R, Palumbo E, Fazio V et al.| title=Cryoglobulinemia in subjects with HCV infection alone, HIV infection and HCV/HIV coinfection. | journal=J Infect | year= 2006 | volume= 52 | issue= 4 | pages= 294-9 | pmid=16026843 | doi=10.1016/j.jinf.2005.05.025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16026843  }} </ref><ref name="pmid29558353">{{cite journal| author=Suszek D, Majdan M| title=[Cryoglobulins and cryoglobulinemic vasculitis]. | journal=Wiad Lek | year= 2018 | volume= 71 | issue= 1 pt 1 | pages= 59-63 | pmid=29558353 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29558353  }} </ref><ref name="pmid27034078">{{cite journal| author=Blank N, Lorenz HM| title=[Cryoglobulinemic vasculitis]. | journal=Z Rheumatol | year= 2016 | volume= 75 | issue= 3 | pages= 303-15 | pmid=27034078 | doi=10.1007/s00393-016-0076-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27034078  }} </ref><ref name="pmid10787003">{{cite journal| author=Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J| title=Mixed cryoglobulinemia: new concepts. | journal=Lupus | year= 2000 | volume= 9 | issue= 2 | pages= 83-91 | pmid=10787003 | doi=10.1191/096120300678828127 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10787003  }} </ref>
*Cryoglobulins are circulating [[immunoglobulins]] or [[Protein|proteins]] that become insoluble at less than 4 degrees celsius.
*[[Cryoglobulinemia]] can lead to a medium-sized vessel [[vasculitis]] due to vascular deposition of circulating [[immune complexes]].
*This leads to the triad of palpable [[purpura]], [[Arthralgia|arthralgias]] and [[peripheral neuropathy]].
*Common causes of [[Cryoglobulinemia CT|cryoglobulinemia]] are primarily [[hematologic]], [[Oncology|oncologic]], and [[rheumatic]]


== Cryoglobulinemia ==
* [[Cryoglobulinemia]] is the presence of high amount of heavy [[Globulin|globulins]] (e.g. [[IgM]]) in the [[bloodstream]] which thicken on exposure to cold.<ref name="pmid16026843">{{cite journal| author=Scotto G, Cibelli DC, Saracino A, Prato R, Palumbo E, Fazio V et al.| title=Cryoglobulinemia in subjects with HCV infection alone, HIV infection and HCV/HIV coinfection. | journal=J Infect | year= 2006 | volume= 52 | issue= 4 | pages= 294-9 | pmid=16026843 | doi=10.1016/j.jinf.2005.05.025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16026843  }} </ref><ref name="pmid29558353">{{cite journal| author=Suszek D, Majdan M| title=[Cryoglobulins and cryoglobulinemic vasculitis]. | journal=Wiad Lek | year= 2018 | volume= 71 | issue= 1 pt 1 | pages= 59-63 | pmid=29558353 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29558353  }} </ref><ref name="pmid27034078">{{cite journal| author=Blank N, Lorenz HM| title=[Cryoglobulinemic vasculitis]. | journal=Z Rheumatol | year= 2016 | volume= 75 | issue= 3 | pages= 303-15 | pmid=27034078 | doi=10.1007/s00393-016-0076-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27034078  }} </ref><ref name="pmid10787003">{{cite journal| author=Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J| title=Mixed cryoglobulinemia: new concepts. | journal=Lupus | year= 2000 | volume= 9 | issue= 2 | pages= 83-91 | pmid=10787003 | doi=10.1191/096120300678828127 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10787003  }} </ref>
* Cryoglobulins are circulating [[immunoglobulins]] or [[Protein|proteins]] that become insoluble at less than 4 degrees celsius.
* [[Cryoglobulinemia]] can lead to a medium-sized vessel [[vasculitis]] due to vascular deposition of circulating [[immune complexes]].
* This leads to the triad of palpable [[purpura]], [[Arthralgia|arthralgias]] and [[peripheral neuropathy]].
* Common causes of [[Cryoglobulinemia CT|cryoglobulinemia]] are primarily [[hematologic]], [[Oncology|oncologic]], and [[rheumatic]]
For more information on [[cryoglobulinemia]], [[Cryoglobulinaemia|'''click here''']].
For more information on [[cryoglobulinemia]], [[Cryoglobulinaemia|'''click here''']].


== Primary amyloidosis ==
==Primary amyloidosis==
* The "AL" refers to [[amyloid]] [[light chain]].<ref name="pmid15198347">{{cite journal |author=Gertz MA |title=The classification and typing of amyloid deposits |journal=Am. J. Clin. Pathol. |volume=121 |issue=6 |pages=787–9 |year=2004 |month=June |pmid=15198347 |doi=10.1309/TR4L-GLVR-JKAM-V5QT |url=http://ajcp.metapress.com/openurl.asp?genre=article&issn=0002-9173&volume=121&issue=6&spage=787}}</ref><ref name="urlAmyloidosis Causes, Diagnosis, Symptoms, and Treatment on MedicineNet.com">{{cite web |url=http://www.medicinenet.com/amyloidosis/article.htm |title=Amyloidosis Causes, Diagnosis, Symptoms, and Treatment on MedicineNet.com |format= |work= |accessdate=}}</ref>
 
** [[AL amyloidosis]] is the most common form of systemic [[amyloidosis]] in the US.
*The "AL" refers to [[amyloid]] [[light chain]].<ref name="pmid15198347">{{cite journal |author=Gertz MA |title=The classification and typing of amyloid deposits |journal=Am. J. Clin. Pathol. |volume=121 |issue=6 |pages=787–9 |year=2004 |month=June |pmid=15198347 |doi=10.1309/TR4L-GLVR-JKAM-V5QT |url=http://ajcp.metapress.com/openurl.asp?genre=article&issn=0002-9173&volume=121&issue=6&spage=787}}</ref><ref name="urlAmyloidosis Causes, Diagnosis, Symptoms, and Treatment on MedicineNet.com">{{cite web |url=http://www.medicinenet.com/amyloidosis/article.htm |title=Amyloidosis Causes, Diagnosis, Symptoms, and Treatment on MedicineNet.com |format= |work= |accessdate=}}</ref>
** Occurs in 5 to 15% of people with [[multiple myeloma]].
**[[AL amyloidosis]] is the most common form of systemic [[amyloidosis]] in the US.
** Treatment can involve application of [[chemotherapy]] similar to that used in [[Multiple myeloma Classification|multiple myeloma]]
**Occurs in 5 to 15% of people with [[multiple myeloma]].
**Treatment can involve application of [[chemotherapy]] similar to that used in [[Multiple myeloma Classification|multiple myeloma]]
 
For more information on primary amyloidosis, '''[[Primary amyloidosis|click here]].'''
For more information on primary amyloidosis, '''[[Primary amyloidosis|click here]].'''


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[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Primary care]]

Latest revision as of 11:52, 19 July 2022


Plasma cell disorders

Overview

Classification

Monoclonal gammopathy of undetermined significance (MGUS)
Malignant monoclonal gammopathies
Multiple myeloma
Malignant lymphoproliferative disorders
Chronic lymphocytic leukemia
Heavy-chain diseases
Cryoglobulinemia
Primary amyloidosis

Differentiating Plasma Cell Disorder

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nazia Fuad M.D., Anmol Pitliya, M.B.B.S. M.D.[2]

Synonyms and keywords: Plasma cell dyscrasia

Overview

Plasma cell disorders are a diverse type of blood disorders characterized by proliferation of a single clone of plasma cells that produces a homogeneous monoclonal (M) protein. These monoclonal paraprotein are seen in the serum or urine. Monoclonal plasma cells are present in the bone marrow or, rarely, in other tissues. Plasma cell disorders include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia (LPL/WM), lymphoproliferative disorders, smoldering multiple myeloma (SMM); solitary or extramedullary plasmacytoma, amyloidosis, and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes). These disorders have been defined by the International Myeloma Working Group in 2006.

Classification

 
 
 
 
 
 
 
 
 
 
 
Plasma cell disorder
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary amyloidosis
 
Malignant monoclonal gammopathy
 
Chronic lymphocytic leukemia
 
 
 
Heavy chain diseases (HCD)
 
Cryoglobulinemia
 
Monoclonal gammopathy of undetermined significance (MGUS)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Multiple myeloma
 
 
Malignant lymphoproliferative disorders
 
γHCD
 
αHCD
 
μHCD
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Benign
(IgG, IgA, IgD, IgM, and,
rarely, free light chains)
 
Associated neoplasms
or other diseases not known to
produce monoclonal proteins
 
Biclonal and triclonal
gammopathies
 
Idiopathic
(Bence Jones
proteinuria)
 
 
 
 
 
 
 
 
 
 
 
 
Waldenstrom macroglobulinemia
 
Malignant lymphoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Symptomatic multiple myeloma
 
Smoldering multiple myeloma
 
Plasma-cell leukemia
 
Non-secretory myeloma
 
IgD myeloma
 
Osteosclerotic myeloma
 
Solitary plasmacytoma of bone
 
Extramedullary plasmacytoma
 

Differential Diagnosis

Disease IgM IgG IgA IgE IgD Monoclonal Ig level SFLC Bone marrow plasma cells Other criteria
IgM MGUS + < 3gm/dl N/A <10%
  • No end-organ damage
Non igM MGUS + + < 3gm/dl N/A <10%
  • No end-organ damage
Smoldering MM + + > 3gm/dl N/A 10-60%
  • No myeloma-defining event
  • No CRAB features
Light chain MGUS <500 mg/24 hrs (urine) Free kappa or lambda light chain
Abnormal ratio (<0.26 or >1.65)
Increase in involved light chain concentration
<10%
  • No end-organ damage
Active symptomatic Multiple myeloma + + + + >3gm/dl >100 >60%
  • ≥1 myeloma-defining event
  • CRAB features
Waldenstrom macroglobulinemia + Variable N/A >10%
Solitary Plasmacytoma + <3mg/dl Abnormal in 47% cases Normal
Primary amyloidosis <3md/dl Light chains of immunoglobulines <10%
  • Myeloma defining events: >60% clonal plasma cells on B.M exam; serum involved: uninvolved FLC ratio >100; >1 focal lesion on MRI >5mm
  • CRAB features: elevated calcium >11mg/dl, renal insufficiency, anemia Hb <10 g/dL , bone disease ≥1 lytic lesions on skeletal radiography, CT, or PET-CT , SFLC: serum free light chains, kappa and lambda immunoglobulin light chains.
  • The normal κ:λ ratio is 0.26 to 1.65 (17,18). A κ:λ ratio of <0.26 strongly suggests the presence of a of plasma cells that are producing clonal λ free light chains. Ratio >1.65 suggests production of clonal κ free light chains.

Monoclonal gammopathies of undetermined significance (MGUS)

For more information about monoclonal gammopathies of undetermined significance click here.

Malignant monoclonal gammopathies

Multiple myeloma

Symptomatic multiple myeloma

  • Patients with active multiple myeloma usually require treatment to prevent progression of disease which can lead to death.

Smoldering multiple myeloma

  • Patients with smoldering (asymptomatic) multiple myeloma are managed by observation and undergoing follow up tests every 3 to 6 months.
  • There is high risk of developing active multiple myeloma.

Plasma-cell leukemia

Non-secretory myeloma

IgD myeloma

  • IgD myeloma mostly affect people of younger age.

Osteosclerotic myeloma

  • It is a rare disorder affecting multiple systems of the body.[6]

Solitary plasmacytoma of bone

Extramedullary plasmacytoma

For more information about multiple myeloma, click here.

Malignant lymphoproliferative disorders

Waldenstrom macroglobulinemia

For more information about Waldenström's macroglobulinemia, click here.

Malignant lymphoma

For more information about malignant lymphoma, click here.

Chronic lymphocytic leukemia

For more information about chronic lymphocytic leukemia, click here

Heavy-chain diseases (HCD)

γHCD

αHCD

μHCD

Cryoglobulinemia

For more information on cryoglobulinemia, click here.

Primary amyloidosis

For more information on primary amyloidosis, click here.

References

  1. Jego G, Bataille R, Geffroy-Luseau A, Descamps G, Pellat-Deceunynck C (June 2006). "Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors". Leukemia. 20 (6): 1130–7. doi:10.1038/sj.leu.2404226. PMID 16628189.
  2. Dinarello CA (February 2009). "Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease". Mayo Clin. Proc. 84 (2): 105–7. doi:10.4065/84.2.105. PMC 2664579. PMID 19181642.
  3. Merlini G, Palladini G (2012). "Differential diagnosis of monoclonal gammopathy of undetermined significance". Hematology Am Soc Hematol Educ Program. 2012: 595–603. doi:10.1182/asheducation-2012.1.595. PMID 23233640.
  4. Sergentanis, Theodoros N.; Zagouri, Flora; Tsilimidos, Gerasimos; Tsagianni, Anastasia; Tseliou, Melina; Dimopoulos, Meletios A.; Psaltopoulou, Theodora (2015). "Risk Factors for Multiple Myeloma: A Systematic Review of Meta-Analyses". Clinical Lymphoma Myeloma and Leukemia. 15 (10): 563–577.e3. doi:10.1016/j.clml.2015.06.003. ISSN 2152-2650.
  5. Rajkumar SV (July 2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.
  6. 6.0 6.1 6.2 6.3 6.4 Rajkumar, S. Vincent (2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". American Journal of Hematology. 91 (7): 719–734. doi:10.1002/ajh.24402. ISSN 0361-8609.
  7. Caers, J.; Paiva, B.; Zamagni, E.; Leleu, X.; Bladé, J.; Kristinsson, S. Y.; Touzeau, C.; Abildgaard, N.; Terpos, E.; Heusschen, R.; Ocio, E.; Delforge, M.; Sezer, O.; Beksac, M.; Ludwig, H.; Merlini, G.; Moreau, P.; Zweegman, S.; Engelhardt, M.; Rosiñol, L. (2018). "Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel". Journal of Hematology & Oncology. 11 (1). doi:10.1186/s13045-017-0549-1. ISSN 1756-8722.
  8. Braggio E, Philipsborn C, Novak A, Hodge L, Ansell S, Fonseca R (September 2012). "Molecular pathogenesis of Waldenstrom's macroglobulinemia". Haematologica. 97 (9): 1281–90. doi:10.3324/haematol.2012.068478. PMC 3436227. PMID 22773606.
  9. Pathology and Genetics of Haemo (World Health Organization Classification of Tumours S.). Oxford Univ Pr. ISBN 92-832-2411-6.
  10. Hallek, Michael (2015). "Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment". American Journal of Hematology. 90 (5): 446–460. doi:10.1002/ajh.23979. ISSN 0361-8609.
  11. Munshi, Nikhil C.; Cabot, Richard C.; Harris, Nancy Lee; Shepard, Jo-Anne O.; Rosenberg, Eric S.; Cort, Alice M.; Ebeling, Sally H.; Peters, Christine C.; Digumarthy, Subba; Rahemtullah, Aliyah (2008). "Case 13-2008". New England Journal of Medicine. 358 (17): 1838–1848. doi:10.1056/NEJMcpc0800959. ISSN 0028-4793.
  12. Scotto G, Cibelli DC, Saracino A, Prato R, Palumbo E, Fazio V; et al. (2006). "Cryoglobulinemia in subjects with HCV infection alone, HIV infection and HCV/HIV coinfection". J Infect. 52 (4): 294–9. doi:10.1016/j.jinf.2005.05.025. PMID 16026843.
  13. Suszek D, Majdan M (2018). "[Cryoglobulins and cryoglobulinemic vasculitis]". Wiad Lek. 71 (1 pt 1): 59–63. PMID 29558353.
  14. Blank N, Lorenz HM (2016). "[Cryoglobulinemic vasculitis]". Z Rheumatol. 75 (3): 303–15. doi:10.1007/s00393-016-0076-4. PMID 27034078.
  15. Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). "Mixed cryoglobulinemia: new concepts". Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.
  16. Gertz MA (2004). "The classification and typing of amyloid deposits". Am. J. Clin. Pathol. 121 (6): 787–9. doi:10.1309/TR4L-GLVR-JKAM-V5QT. PMID 15198347. Unknown parameter |month= ignored (help)
  17. "Amyloidosis Causes, Diagnosis, Symptoms, and Treatment on MedicineNet.com".

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