Myelofibrosis differential diagnosis: Difference between revisions

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*[[Juvenile rheumatoid arthritis]] (JRA)
*[[Juvenile rheumatoid arthritis]] (JRA)
*[[Still's disease]]<br>[[Systemic lupus erythematosus]] (SLE)
*[[Still's disease]]<br>[[Systemic lupus erythematosus]] (SLE)
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|}<sub>* = may cause massive splenomegaly</sub>


==References==
==References==

Revision as of 15:25, 11 March 2016

Myelofibrosis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]

Overview

Differentiating Myelofibrosis from other Diseases

Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis. They are tabulated below.[1][2]

Type of diseases Diseases
Hematological causes Sickle cell disease
Metabolic bone disorders Hyperthyroidism
Hypoparathyroidism
Renal osteodystrophy
Congenital Sclerosing bone dysplasia
Osteopetrosis
Pyknodysostosis
Malignancy Lymphoma: infiltration
Leukaemia: infiltration
Osteoblastic metastases
Other Paget disease
Fluorosis
Mastocytosis
Hepatitis C associated osteosclerosis (HCAO)

Myelofibrosis must be differentiated from other diseases that cause splenomegaly. They are tabulated below.[1][3]

Type of diseases Diseases
Hematological causes Anaemia

Neoplastic/proliferative/redistribution of hematopoesis

Hemodynamic Cirrhosis: portal hypertension
Congestive splenomegaly (Banti syndrome)
Splenic vein obstruction
Portal vein obstruction
Right heart failure
Infection Viral
Storage diseases/metabolic/infiltrative disorders Gaucher disease
Glycogen storage disease
Mucopolysaccharidoses
Niemann-Pick disease
Hemochromatosis
Amyloidosis
Porphyria
Sarcoidosis
Neoplastic Lymphoma (common)
Metastases (breast, lung, colon, ovary, melanoma)
Hemangioma
Lymphangioma
Angiosarcoma
Trauma Hematoma
Pseudocyst
Connective tissue disorders Rheumatoid arthritis

* = may cause massive splenomegaly

References

  1. 1.0 1.1 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
  2. Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016
  3. Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/splenomegaly. Accessed on March 11, 2016

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