Myelofibrosis differential diagnosis: Difference between revisions

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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Other
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Other
| style="padding: 5px 5px; background: #F5F5F5;" |[[Paget disease]]<br>[[Fluorosis]]<br>[[Mastocytosis]]<br>[[osteosclerosis|Hepatitis C associated osteosclerosis]] (HCAO)
| style="padding: 5px 5px; background: #F5F5F5;" |[[Paget disease]]<br>[[Fluorosis]]<br>[[Mastocytosis]]<br>[[osteosclerosis|Hepatitis C associated osteosclerosis]] (HCAO)
|}
Myelofibrosis must be differentiated from other diseases that cause [[splenomegaly]]. They are tabulated below.<ref name=myelofibrosisdiffdiagnsosiseradio1>Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref><ref name=splenomegalydiffdiagnosisradio1>Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/splenomegaly. Accessed on March 11, 2016</ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width:650px"
|valign=top|
|+
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type of diseases}}
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Diseases}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Hematological causes
| style="padding: 5px 5px; background: #F5F5F5;" |Anaemia
*[[Sickle cell disease]]
*[[Thalassemia]]
*[[Hereditary spherocytosis]]
*[[Pyruvate kinase deficiency]]
*[[Thrombotic thrombocytopaenic purpura]] (TTP)<br>Neoplastic/proliferative/redistribution of hematopoesis
*[[Leukemia]] (especially [[CML]]*)
*[[Polycythaemia rubra vera]] (PRV) *
*[[Waldenström macroglobulinaemia]]
*[[Extramedullary haematopoiesis]]
*[[Osteopetrosis]]
*[[Idiopathic hypereosinophilic syndrome]]
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Hemodynamic
| style="padding: 5px 5px; background: #F5F5F5;" |[[Cirrhosis]]: [[portal hypertension]]<br>Congestive splenomegaly ([[Banti syndrome]])<br>[[Splenic vein obstruction]]<br>[[Portal vein obstruction]]<br>[[Right heart failure]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Infection
| style="padding: 5px 5px; background: #F5F5F5;" |Viral
*[[EBV]] (infectious mononucleosis) - (common)
*[[AIDS]]
*[[CMV]]
*[[Herpes simplex virus]]
*[[Rubella]]<br>Bacterial
*[[Tuberculosis]] (miliary)
*[[Tularemia]]
*[[Subacute bacterial endocarditis]]
*[[Typhoid fever]]
*[[Brucellosis]]
*[[Syphilis]]
*[[Abscess]]<br>Fungal
*[[Histoplasmosis]] (common)
*[[Candidiasis]]<br>Parasitic disease
*[[Malaria]]*
*[[Schistosomiasis]]
*[[Hydatid disease]]
*[[Leishmaniasis]] (kala-azar)
*[[Rickettsial]]
:*[[Typhus]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Storage diseases/metabolic/infiltrative disorders
| style="padding: 5px 5px; background: #F5F5F5;" |[[Gaucher disease]]<br>[[Glycogen storage disease]]<br>[[Mucopolysaccharidoses]]<br>[[Niemann-Pick disease]]<br>[[Hemochromatosis]]<br>[[Amyloidosis]]<br>[[Porphyria]]<br>[[Sarcoidosis]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Neoplastic
| style="padding: 5px 5px; background: #F5F5F5;" |[[Lymphoma]] (common)<br>[[Metastases]] (breast, lung, colon, ovary, melanoma)<br>[[Hemangioma]]<br>[[Lymphangioma]]<br>[[Angiosarcoma]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Trauma
| style="padding: 5px 5px; background: #F5F5F5;" |[[Hematoma]]<br>[[Pseudocyst]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Connective tissue disorders
| style="padding: 5px 5px; background: #F5F5F5;" |[[Rheumatoid arthritis]]
*[[Felty syndrome]]
*[[Juvenile rheumatoid arthritis]] (JRA)
*[[Still's disease]]<br>[[Systemic lupus erythematosus]] (SLE)
|}
|}



Revision as of 15:23, 11 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]

Overview

Differentiating Myelofibrosis from other Diseases

Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis. They are tabulated below.[1][2]

Type of diseases Diseases
Hematological causes Sickle cell disease
Metabolic bone disorders Hyperthyroidism
Hypoparathyroidism
Renal osteodystrophy
Congenital Sclerosing bone dysplasia
Osteopetrosis
Pyknodysostosis
Malignancy Lymphoma: infiltration
Leukaemia: infiltration
Osteoblastic metastases
Other Paget disease
Fluorosis
Mastocytosis
Hepatitis C associated osteosclerosis (HCAO)

Myelofibrosis must be differentiated from other diseases that cause splenomegaly. They are tabulated below.[1][3]

Type of diseases Diseases
Hematological causes Anaemia
Hemodynamic Cirrhosis: portal hypertension
Congestive splenomegaly (Banti syndrome)
Splenic vein obstruction
Portal vein obstruction
Right heart failure
Infection Viral
Storage diseases/metabolic/infiltrative disorders Gaucher disease
Glycogen storage disease
Mucopolysaccharidoses
Niemann-Pick disease
Hemochromatosis
Amyloidosis
Porphyria
Sarcoidosis
Neoplastic Lymphoma (common)
Metastases (breast, lung, colon, ovary, melanoma)
Hemangioma
Lymphangioma
Angiosarcoma
Trauma Hematoma
Pseudocyst
Connective tissue disorders Rheumatoid arthritis

References

  1. 1.0 1.1 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
  2. Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016
  3. Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/splenomegaly. Accessed on March 11, 2016

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