Low flow, low gradient aortic stenosis: Difference between revisions

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Latest revision as of 17:03, 6 December 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2] Usama Talib, BSc, MD [3]

Synonyms and keywords: Low flow low gradient aortic stenosis, LF-LG aortic stenosis, low flow low gradient aortic stenosis with low ejection fraction, low flow flow gradient aortic stenosis with normal ejection fraction

Overview

In aortic stenosis, as the aortic orifice area decreases the transvalvular gradient increases; in fact, when the aortic valve effective orifice area decreases below 1 cm² the mean transvalvular gradient is expected to be greater than 40 mmHg.^[1]^[2]The transvalvular gradient is highly dependent on the flow of blood through the valve; however, when severe systolic and/or diastolic myocardial dysfunction coexist with the aortic stenosis, there is a decrease in the flow through the valve leading to a prominent decrease in the transvalvular gradient, a condition referred to as low flow, low gradient aortic stenosis (LF-LG AS). LF-LG AS is a challenging diagnosis that must be done in order to tailor the management plan. It is important to recognize this entity because it might lead to either underestimation or overestimation of the degree of severity of the aortic stenosis. Two various scenarios occur in the setting of LF-LG AS depending on the status of the left ventricular ejection fraction (LVEF): LF-LG AS with low LVEF and LF-LG AS with normal LVEF.^[3]

Epidemiology

Low flow low gradient aortic stenosis with low ejection fraction is reported in approximately 5 to 10% of patients with severe aortic stenosis; whereas low flow low gradient aortic stenosis with normal left ventricular ejection fraction is observed in 10 to 25% of patients with severe aortic stenosis.^[4]^[5]

Pathophysiology

Low Flow, Low Gradient Aortic Stenosis with Low Ejection Fraction

When ventricular systolic dysfunction is present, the myocardium can not contract strongly enough to pump blood with a lot of pressure. In this case, low flow and subsequent low transvalvular gradient are present and this entity is referred to as LF-LG AS with low LVEF.
LF-LG AS with low LVEF is defined as:^[1]^[2]^[3]

An aortic valve areas < 1.0 cm², and
A left ventricular ejection fraction < 40-50%( 30% in other references),^[4] and
A mean pressure difference or gradient across the aortic valve of < 40 mm Hg

When low flow low gradient aortic stenosis is present, the challenge is to determine whether the LF-LG AS with low LVEF is a true severe aortic stenosis or a pseudo-severe aortic stenosis. It is very important to differentiate these two entities as they have different outcomes following aortic valve replacement.^[3]

True severe aortic stenosis:

In true severe aortic stenosis, the aortic stenosis is so severe that it caused secondary left ventricular dysfunction. This systolic dysfunction causes decreased contractility leading to decreased ejection force and low transvalvular flow and gradient.^[3]

Pseudo-severe aortic stenosis:

Following are the features of Pseudo-severe Aortic Stenosis.^[3]^[6]^[7]^[8]^[9]^[10]

In pseudo-severe aortic stenosis, the aortic stenosis is mild or moderate and it co-exists with another myocardial disease that is independent from the aortic stenosis. Overestimation of the severity of the aortic stenosis may happen in this context.
The presence of fibrosis in the left ventricle may cause an incomplete recovery after aortic valve replacement.^[11]
This scenario can also occur among patients in whom there is a history of myocardial infarction and insufficient contractility to mount an aortic gradient.
It may also occur when myocardial fibrosis develops due to longstanding aortic stenosis.

Low Flow, Low Gradient Aortic Stenosis with Normal Ejection Fraction

LF-LG AS with normal ejection fraction has been recently described.^[3]^[12]^[13]^[14]

LF-LG aortic stenosis with normal LVEF is usually an advanced stage of valvular and myocardial diseases. The normal ejection fraction might lead to an underestimation of the severity of the aortic stenosis.
LF-LG AS with normal ejection fraction has a lot of similarities with normal ejection fraction diastolic heart failure. In fact, it is usually present in older females and in the context of hypertension. The underlying pathophysiology of LF-LG AS with normal ejection fraction is a restrictive myocardium.
LF-LG AS with normal ejection fraction is characterized by the presence of extensive remodeling due to predominant diastolic dysfunction as well as systolic dysfunction. However, the decrease in the systolic performance of the left ventricle does not contribute to a decrease in the ejection fraction.

Shown below is a table depicting the differences between LF-LG AS with low LVEF and LF-LG AS with normal LVEF.

LF-LG AS	Percentage of the Cases of Severe AS Caused by LF-LG AS	Pathophysiology	Diagnostic Challenges
LF-LG AS with low LVEF	5-10% of severe aortic stenosis	Decreased systolic function -Dilated left ventricle -Decreased contractility	Differentiation between severe aortic stenosis and pseudo-severe aortic stenosis
LF-LG AS with normal LVEF	10-25% of severe aortic stenosis	Decreased diastolic function -Small left ventricle -Decreased compliance	Underestimation of the severity of aortic stenosis Confounding measurement errors and small ventricle body size

Diagnosis

Echocardiography is fairly accurate in the assessment of the severity of aortic stenosis in patients with normal or near normal cardiac output. However, dobutamine stress echocardiography or cardiac catheterization may be required to accurately assess the severity of aortic stenosis in patients with low output aortic stenosis.^[8]^[14]

Low Dose Dobutamine Stress Echocardiography

Low dose (<20 microgram/Kg/min) dobutamine stress echocardiography allows:^[6]^[9]
- The differentiation between severe and pseudo-severe low flow low gradient aortic stenosis through the degree of change of both the effective orifice area and the transvalvular gradient after dobutamine infusion. Changes following dobutamine infusion are due to the fact that dobutamine causes increase in the flow across the aortic valve.
  - In pseudosevere aortic stenosis, there is increase in the effective orifice area of the aortic valve, in a way that it is larger than 1.2 cm2, and slight increase in the gradient, in a way that is inferior to 40 mmHg.
  - In severe aortic stenosis, there is absence or little increase in the effective orifice area of the aortic valve, in a way that is inferior to 1.2 cm2, and increase in the gradient to become greater than 40 mmHg.
- The assessment of the presence or absence of left ventricular flow reserve through the degree of change in stroke volume following dobutamine infusion.
  - Left ventricular flow reserve is an indicator of operative mortality. Left ventricle flow reserve does not predict recovery of left ventricle after aortic valve replacement nor the resolution of symptoms.^[3]
  - The aortic valve area should increase to more than 1-1.2 cm2 with a dobutamine infusion and the mean pressure gradient should rise above 30 mm Hg. While early surgical mortality is 32-33% in patients who fail to to achieve these improvements with dobutamine infusions, it is only 5–7% in patients who demonstrate an increase in their contractility and gradient. Five years survival after surgery was 88% in patients with improved contractility and only 10–25% in patients with unimproved contractility.

Shown below is an algorithm summarizing the interpretation of the results of low dose dobutamine stress echocardiography in the evaluation of low flow, low gradient aortic stenosis.^[3]

Abbreviations: EOA: Effective orifice area; ΔP_mean: mean pressure gradient

Ultrasound evaluation of aortic stenosis
Effective orifice area (EOA)≤ 1 cm²
Pressure gradient (ΔP)<40 mmHg

Low grade low flow aortic stenosis

Normal left ventricular ejection fraction

Left ventricular ejection fraction≤ 40-50%

Dobutamine stress test

Increase in stroke volume by ≥ 20%

Increase in stroke volume by <20%

Presence of left ventricular flow reserve

Absence of left ventricular flow reserve

ΔP≥40
EOA<1-1.2

ΔP<40
EOA≥1-1.2

EOA<1-1.2

True severe aortic stenosis

Pseudo-severe aortic stenosis

True severe aortic stenosis

Treatment

Surgical and Medical Treatment

Aortic valve replacement is the treatment of choice for aortic stenosis.^[15]^[16]Given the associated operative risks with aortic valve replacement (AVR), true severe low flow low gradient aortic stenosis must be differentiated from pseudoaortic stenosis as the former benefit from AVR and the latter does not necessarily benefit from AVR. In addition, in case of low flow low gradient aortic stenosis with low ejection fraction, the presence or absence of reserve flow dictates the treatment plan as the operative mortality increases in the absence of reserve flow. As low flow low gradient aortic stenosis with normal ejection fraction is a newly described entity, there is no yet clear recommendations for the management.^[17]^[18]^[19]

Shown below is an algorithm of the management of low flow, low gradient aortic stenosis.^[3]

Abbreviations: AVR: Aortic valve replacement; EOA: Effective orifice area; ΔP_mean: mean pressure gradient

Low grade low flow aortic stenosis

Normal left ventricular ejection fraction

Left ventricular ejection fraction≤ 40-50%

No specific recommendations:
- Surgical AVR, or
- Transcather AVR, or
- Medical treatment

Dobutamine stress test

Increase in stroke volume by ≥ 20%

Increase in stroke volume by <20%

ΔP≥40
EOA<1-1.2

ΔP<40
EOA≥1-1.2

EOA<1-1.2

True severe aortic stenosis

Pseudo-severe aortic stenosis

True severe aortic stenosis

Surgical AVR
with/without CABG

Medical treatment
Close follow up

Transcather AVR

Operative Mortality Risk Factors

The risk factors for operative mortality in the case of low flow, low gradient aortic stenosis with low ventricle ejection fraction are:^[4]^[20]

Absence of left ventricle flow reserve
Decreased pre-operative mean transvalvular gradient below 20mmHg at rest
Coronary artery disease involving several vessels

ACC/AHA Guidelines^[1]

Dobutamine Stress Echocardiography

Class IIa
"1.Dobutamine stress echocardiography is reasonable to evaluate patients with low-flow/low-gradient aortic stenosis and left ventricular dysfunction.(Level of Evidence: B) "
"2.Cardiac catheterization for hemodynamic measurements with infusion of dobutamine can be useful for evaluation of patients with low-flow/low-gradient aortic stenosis and left ventricular dysfunction. (Level of Evidence: C) "

References

↑ ^1.0 ^1.1 ^1.2 Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD; et al. (2008). "2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons". J Am Coll Cardiol. 52 (13): e1–142. doi:10.1016/j.jacc.2008.05.007. PMID 18848134.
↑ ^2.0 ^2.1 Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H; et al. (2013). "[Guidelines on the management of valvular heart disease (version 2012). The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)]". G Ital Cardiol (Rome). 14 (3): 167–214. doi:10.1714/1234.13659. PMID 23474606.
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Pibarot P, Dumesnil JG (2012). "Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction". J Am Coll Cardiol. 60 (19): 1845–53. doi:10.1016/j.jacc.2012.06.051. PMID 23062546.
↑ ^4.0 ^4.1 ^4.2 Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO; et al. (2000). "Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients". Circulation. 101 (16): 1940–6. PMID 10779460.
↑ Kulik A, Burwash IG, Kapila V, Mesana TG, Ruel M (2006). "Long-term outcomes after valve replacement for low-gradient aortic stenosis: impact of prosthesis-patient mismatch". Circulation. 114 (1 Suppl): I553–8. doi:10.1161/CIRCULATIONAHA.105.001180. PMID 16820636.
↑ ^6.0 ^6.1 deFilippi CR, Willett DL, Brickner ME, Appleton CP, Yancy CW, Eichhorn EJ; et al. (1995). "Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients". Am J Cardiol. 75 (2): 191–4. PMID 7810504.
↑ Schwammenthal E, Vered Z, Moshkowitz Y, Rabinowitz B, Ziskind Z, Smolinski AK; et al. (2001). "Dobutamine echocardiography in patients with aortic stenosis and left ventricular dysfunction: predicting outcome as a function of management strategy". Chest. 119 (6): 1766–77. PMID 11399704.
↑ ^8.0 ^8.1 Monin JL, Quéré JP, Monchi M, Petit H, Baleynaud S, Chauvel C; et al. (2003). "Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics". Circulation. 108 (3): 319–24. doi:10.1161/01.CIR.0000079171.43055.46. PMID 12835219.
↑ ^9.0 ^9.1 Nishimura RA, Grantham JA, Connolly HM, Schaff HV, Higano ST, Holmes DR (2002). "Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory". Circulation. 106 (7): 809–13. PMID 12176952.
↑ Zuppiroli A, Mori F, Olivotto I, Castelli G, Favilli S, Dolara A (2003). "Therapeutic implications of contractile reserve elicited by dobutamine echocardiography in symptomatic, low-gradient aortic stenosis". Ital Heart J. 4 (4): 264–70. PMID 12784780.
↑ Carabello BA, Green LH, Grossman W, Cohn LH, Koster JK, Collins JJ (1980). [[]]: 42–8 http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7379284. Retrieved 2012-04-10. Unknown parameter |month= ignored (help); Missing or empty |title= (help)
↑ Hachicha Z, Dumesnil JG, Bogaty P, Pibarot P (2007). "Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival". Circulation. 115 (22): 2856–64. doi:10.1161/CIRCULATIONAHA.106.668681. PMID 17533183.
↑ Cramariuc D, Cioffi G, Rieck AE, Devereux RB, Staal EM, Ray S; et al. (2009). "Low-flow aortic stenosis in asymptomatic patients: valvular-arterial impedance and systolic function from the SEAS Substudy". JACC Cardiovasc Imaging. 2 (4): 390–9. doi:10.1016/j.jcmg.2008.12.021. PMID 19580719.
↑ ^14.0 ^14.1 Lancellotti P, Magne J, Donal E, Davin L, O'Connor K, Rosca M; et al. (2012). "Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification". J Am Coll Cardiol. 59 (3): 235–43. doi:10.1016/j.jacc.2011.08.072. PMID 22240128.
↑ Pai RG, Varadarajan P, Razzouk A (2008). "Survival benefit of aortic valve replacement in patients with severe aortic stenosis with low ejection fraction and low gradient with normal ejection fraction". Ann Thorac Surg. 86 (6): 1781–9. doi:10.1016/j.athoracsur.2008.08.008. PMID 19021976.
↑ Tarantini G, Covolo E, Razzolini R, Bilato C, Frigo AC, Napodano M; et al. (2011). "Valve replacement for severe aortic stenosis with low transvalvular gradient and left ventricular ejection fraction exceeding 0.50". Ann Thorac Surg. 91 (6): 1808–15. doi:10.1016/j.athoracsur.2011.02.057. PMID 21619977.
↑ Hachicha Z, Dumesnil JG, Pibarot P (2009). "Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis". J Am Coll Cardiol. 54 (11): 1003–11. doi:10.1016/j.jacc.2009.04.079. PMID 19729117.
↑ Malouf J, Le Tourneau T, Pellikka P, Sundt TM, Scott C, Schaff HV; et al. (2012). "Aortic valve stenosis in community medical practice: determinants of outcome and implications for aortic valve replacement". J Thorac Cardiovasc Surg. 144 (6): 1421–7. doi:10.1016/j.jtcvs.2011.09.075. PMID 22336754.
↑ Belkin RN, Khalique O, Aronow WS, Ahn C, Sharma M (2011). "Outcomes and survival with aortic valve replacement compared with medical therapy in patients with low-, moderate-, and severe-gradient severe aortic stenosis and normal left ventricular ejection fraction". Echocardiography. 28 (4): 378–87. doi:10.1111/j.1540-8175.2010.01372.x. PMID 21323995.
↑ Vaquette B, Corbineau H, Laurent M, Lelong B, Langanay T, de Place C; et al. (2005). "Valve replacement in patients with critical aortic stenosis and depressed left ventricular function: predictors of operative risk, left ventricular function recovery, and long term outcome". Heart. 91 (10): 1324–9. doi:10.1136/hrt.2004.044099. PMC 1769144. PMID 16162627.

[pmid18848134-1] 1.0 ^1.1 ^1.2 Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD; et al. (2008). "2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons". J Am Coll Cardiol. 52 (13): e1–142. doi:10.1016/j.jacc.2008.05.007. PMID 18848134.

[pmid23474606-2] 2.0 ^2.1 Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H; et al. (2013). "[Guidelines on the management of valvular heart disease (version 2012). The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)]". G Ital Cardiol (Rome). 14 (3): 167–214. doi:10.1714/1234.13659. PMID 23474606.

[pmid23062546-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Pibarot P, Dumesnil JG (2012). "Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction". J Am Coll Cardiol. 60 (19): 1845–53. doi:10.1016/j.jacc.2012.06.051. PMID 23062546.

[pmid10779460-4] 4.0 ^4.1 ^4.2 Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO; et al. (2000). "Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients". Circulation. 101 (16): 1940–6. PMID 10779460.

[pmid16820636-5] Kulik A, Burwash IG, Kapila V, Mesana TG, Ruel M (2006). "Long-term outcomes after valve replacement for low-gradient aortic stenosis: impact of prosthesis-patient mismatch". Circulation. 114 (1 Suppl): I553–8. doi:10.1161/CIRCULATIONAHA.105.001180. PMID 16820636.

[pmid7810504-6] 6.0 ^6.1 deFilippi CR, Willett DL, Brickner ME, Appleton CP, Yancy CW, Eichhorn EJ; et al. (1995). "Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients". Am J Cardiol. 75 (2): 191–4. PMID 7810504.

[pmid11399704-7] Schwammenthal E, Vered Z, Moshkowitz Y, Rabinowitz B, Ziskind Z, Smolinski AK; et al. (2001). "Dobutamine echocardiography in patients with aortic stenosis and left ventricular dysfunction: predicting outcome as a function of management strategy". Chest. 119 (6): 1766–77. PMID 11399704.

[pmid12835219-8] 8.0 ^8.1 Monin JL, Quéré JP, Monchi M, Petit H, Baleynaud S, Chauvel C; et al. (2003). "Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics". Circulation. 108 (3): 319–24. doi:10.1161/01.CIR.0000079171.43055.46. PMID 12835219.

[pmid12176952-9] 9.0 ^9.1 Nishimura RA, Grantham JA, Connolly HM, Schaff HV, Higano ST, Holmes DR (2002). "Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory". Circulation. 106 (7): 809–13. PMID 12176952.

[pmid12784780-10] Zuppiroli A, Mori F, Olivotto I, Castelli G, Favilli S, Dolara A (2003). "Therapeutic implications of contractile reserve elicited by dobutamine echocardiography in symptomatic, low-gradient aortic stenosis". Ital Heart J. 4 (4): 264–70. PMID 12784780.

[pmid-11] Carabello BA, Green LH, Grossman W, Cohn LH, Koster JK, Collins JJ (1980). [[]]: 42–8 http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7379284. Retrieved 2012-04-10. Unknown parameter |month= ignored (help); Missing or empty |title= (help)

[pmid17533183-12] Hachicha Z, Dumesnil JG, Bogaty P, Pibarot P (2007). "Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival". Circulation. 115 (22): 2856–64. doi:10.1161/CIRCULATIONAHA.106.668681. PMID 17533183.

[pmid19580719-13] Cramariuc D, Cioffi G, Rieck AE, Devereux RB, Staal EM, Ray S; et al. (2009). "Low-flow aortic stenosis in asymptomatic patients: valvular-arterial impedance and systolic function from the SEAS Substudy". JACC Cardiovasc Imaging. 2 (4): 390–9. doi:10.1016/j.jcmg.2008.12.021. PMID 19580719.

[pmid22240128-14] 14.0 ^14.1 Lancellotti P, Magne J, Donal E, Davin L, O'Connor K, Rosca M; et al. (2012). "Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification". J Am Coll Cardiol. 59 (3): 235–43. doi:10.1016/j.jacc.2011.08.072. PMID 22240128.

[pmid19021976-15] Pai RG, Varadarajan P, Razzouk A (2008). "Survival benefit of aortic valve replacement in patients with severe aortic stenosis with low ejection fraction and low gradient with normal ejection fraction". Ann Thorac Surg. 86 (6): 1781–9. doi:10.1016/j.athoracsur.2008.08.008. PMID 19021976.

[pmid21619977-16] Tarantini G, Covolo E, Razzolini R, Bilato C, Frigo AC, Napodano M; et al. (2011). "Valve replacement for severe aortic stenosis with low transvalvular gradient and left ventricular ejection fraction exceeding 0.50". Ann Thorac Surg. 91 (6): 1808–15. doi:10.1016/j.athoracsur.2011.02.057. PMID 21619977.

[pmid19729117-17] Hachicha Z, Dumesnil JG, Pibarot P (2009). "Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis". J Am Coll Cardiol. 54 (11): 1003–11. doi:10.1016/j.jacc.2009.04.079. PMID 19729117.

[pmid22336754-18] Malouf J, Le Tourneau T, Pellikka P, Sundt TM, Scott C, Schaff HV; et al. (2012). "Aortic valve stenosis in community medical practice: determinants of outcome and implications for aortic valve replacement". J Thorac Cardiovasc Surg. 144 (6): 1421–7. doi:10.1016/j.jtcvs.2011.09.075. PMID 22336754.

[pmid21323995-19] Belkin RN, Khalique O, Aronow WS, Ahn C, Sharma M (2011). "Outcomes and survival with aortic valve replacement compared with medical therapy in patients with low-, moderate-, and severe-gradient severe aortic stenosis and normal left ventricular ejection fraction". Echocardiography. 28 (4): 378–87. doi:10.1111/j.1540-8175.2010.01372.x. PMID 21323995.

[pmid16162627-20] Vaquette B, Corbineau H, Laurent M, Lelong B, Langanay T, de Place C; et al. (2005). "Valve replacement in patients with critical aortic stenosis and depressed left ventricular function: predictors of operative risk, left ventricular function recovery, and long term outcome". Heart. 91 (10): 1324–9. doi:10.1136/hrt.2004.044099. PMC 1769144. PMID 16162627.

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@@ Line 1: / Line 1: @@
 __NOTOC__
+{| class="infobox" style="float:right;"
+|-
+| [[File:Siren.gif|30px|link= Low flow low gradient aortic stenosis resident survival guide]]|| <br> || <br>
+| [[Low flow low gradient aortic stenosis resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
+|}
 {{Aortic stenosis}}
-{{CMG}}; {{AE}} {{Rim}}
+{{CMG}}; {{AE}} {{Rim}} {{USAMA}}
 {{SK}} Low flow low gradient aortic stenosis, LF-LG aortic stenosis, low flow low gradient aortic stenosis with low ejection fraction, low flow flow gradient aortic stenosis with normal ejection fraction
 ==Overview==
-In [[aortic stenosis]], as the aortic orifice area decreases the transvalvular gradient increases; in fact, when the [[aortic valve]] effective orifice area decreases below 1 cm<sup>2</sup> the mean transvalvular gradient is expected to be greater than 40 mmHg.  The transvalvular gradient is highly dependent on the flow of [[blood]] through the valve; however, when severe systolic and/or diastolic myocardial dysfunction coexist with the [[aortic stenosis]], there is a decrease in the flow through the valve leading to a prominent decrease in the transvalvular gradient, a condition referred to as low flow, low gradient aortic stenosis (LF-LG AS).  LF-LG AS is a challenging diagnosis that must be done in order to tailor the management plan.  It is important to recognize this entity because it might lead to either underestimation or overestimation of the degree of severity of the [[aortic stenosis]].  Two various scenarios occur in the setting of LF-LG AS depending on the status of the left ventricular [[ejection fraction]] (LVEF): '''LF-LG AS with low LVEF''' and '''LF-LG AS with normal LVEF'''.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
+In [[aortic stenosis]], as the aortic orifice area decreases the transvalvular gradient increases; in fact, when the [[aortic valve]] effective orifice area decreases below 1 cm<sup>2</sup> the mean transvalvular gradient is expected to be greater than 40 mmHg.<ref name="pmid18848134">{{cite journal| author=Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD et al.| title=2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. | journal=J Am Coll Cardiol | year= 2008 | volume= 52 | issue= 13 | pages= e1-142 | pmid=18848134 | doi=10.1016/j.jacc.2008.05.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18848134  }} </ref><ref name="pmid23474606">{{cite journal| author=Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H et al.| title=[Guidelines on the management of valvular heart disease (version 2012). The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)]. | journal=G Ital Cardiol (Rome) | year= 2013 | volume= 14 | issue= 3 | pages= 167-214 | pmid=23474606 | doi=10.1714/1234.13659 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23474606  }} </ref>The transvalvular gradient is highly dependent on the flow of [[blood]] through the valve; however, when severe systolic and/or diastolic myocardial dysfunction coexist with the [[aortic stenosis]], there is a decrease in the flow through the valve leading to a prominent decrease in the transvalvular gradient, a condition referred to as low flow, low gradient aortic stenosis (LF-LG AS).  LF-LG AS is a challenging diagnosis that must be done in order to tailor the management plan.  It is important to recognize this entity because it might lead to either underestimation or overestimation of the degree of severity of the [[aortic stenosis]].  Two various scenarios occur in the setting of LF-LG AS depending on the status of the left ventricular [[ejection fraction]] (LVEF): '''LF-LG AS with low LVEF''' and '''LF-LG AS with normal LVEF'''.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
 ==Epidemiology==
-Low flow low gradient aortic stenosis with low ejection fraction is reported in approximately 5 to 10% of patients with severe aortic stenosis; whereas low flow low gradient aortic stenosis with normal left ventricular [[ejection fraction]] is observed in 10 to 25% of patients with severe [[aortic stenosis]].<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
+Low flow low gradient aortic stenosis with low ejection fraction is reported in approximately 5 to 10% of patients with severe aortic stenosis; whereas low flow low gradient aortic stenosis with normal left ventricular [[ejection fraction]] is observed in 10 to 25% of patients with severe [[aortic stenosis]].<ref name="pmid10779460">{{cite journal| author=Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO et al.| title=Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients. | journal=Circulation | year= 2000 | volume= 101 | issue= 16 | pages= 1940-6 | pmid=10779460 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10779460  }} </ref><ref name="pmid16820636">{{cite journal| author=Kulik A, Burwash IG, Kapila V, Mesana TG, Ruel M| title=Long-term outcomes after valve replacement for low-gradient aortic stenosis: impact of prosthesis-patient mismatch. | journal=Circulation | year= 2006 | volume= 114 | issue= 1 Suppl | pages= I553-8 | pmid=16820636 | doi=10.1161/CIRCULATIONAHA.105.001180 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16820636  }} </ref>
 ==Pathophysiology==
 ===Low Flow, Low Gradient Aortic Stenosis with Low Ejection Fraction===
 *When ventricular [[systolic dysfunction]] is present, the [[myocardium]] can not contract strongly enough to pump blood with a lot of pressure. In this case, low flow and subsequent low transvalvular gradient are present and this entity is referred to as LF-LG AS with low LVEF.
-*LF-LG AS with low LVEF is defined as:
+*LF-LG AS with low LVEF is defined as:<ref name="pmid18848134">{{cite journal| author=Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD et al.| title=2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. | journal=J Am Coll Cardiol | year= 2008 | volume= 52 | issue= 13 | pages= e1-142 | pmid=18848134 | doi=10.1016/j.jacc.2008.05.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18848134  }} </ref><ref name="pmid23474606">{{cite journal| author=Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H et al.| title=[Guidelines on the management of valvular heart disease (version 2012). The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)]. | journal=G Ital Cardiol (Rome) | year= 2013 | volume= 14 | issue= 3 | pages= 167-214 | pmid=23474606 | doi=10.1714/1234.13659 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23474606  }} </ref><ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
 #An [[aortic valve area|aortic valve areas]] < 1.0 cm<sup>2</sup>, and
-#A [[ejection fraction|left ventricular ejection fraction]] < 40%<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref> ( 30% in other references)<ref name="pmid10779460">{{cite journal| author=Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO et al.| title=Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients. | journal=Circulation | year= 2000 | volume= 101 | issue= 16 | pages= 1940-6 | pmid=10779460 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10779460  }} </ref>, and
+#A [[ejection fraction|left ventricular ejection fraction]] < 40-50%( 30% in other references),<ref name="pmid10779460">{{cite journal| author=Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO et al.| title=Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients. | journal=Circulation | year= 2000 | volume= 101 | issue= 16 | pages= 1940-6 | pmid=10779460 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10779460  }} </ref> and
-#A [[Intravascular pressure gradient|mean pressure difference or gradient]] across the aortic valve of < 30 mm Hg
+#A [[Intravascular pressure gradient|mean pressure difference or gradient]] across the aortic valve of < 40 mm Hg
 *When low flow low gradient aortic stenosis is present, the challenge is to determine whether the LF-LG AS with low LVEF is a true severe aortic stenosis or a pseudo-severe aortic stenosis.  It is very important to differentiate these two entities as they have different outcomes following aortic valve replacement.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
 =====True severe aortic stenosis:=====
-* In true severe aortic stenosis, the [[aortic stenosis]] is so '''severe''' that it caused secondary left ventricular dysfunction. This systolic dysfunction causes decreased contractility leading to decreased ejection force and low transvalvular flow and gradient.
+* In true severe aortic stenosis, the [[aortic stenosis]] is so '''severe''' that it caused secondary left ventricular dysfunction. This systolic dysfunction causes decreased contractility leading to decreased ejection force and low transvalvular flow and gradient.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
 =====Pseudo-severe aortic stenosis:=====
+Following are the features of Pseudo-severe Aortic Stenosis.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref><ref name="pmid7810504">{{cite journal| author=deFilippi CR, Willett DL, Brickner ME, Appleton CP, Yancy CW, Eichhorn EJ et al.| title=Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. | journal=Am J Cardiol | year= 1995 | volume= 75 | issue= 2 | pages= 191-4 | pmid=7810504 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7810504  }} </ref><ref name="pmid11399704">{{cite journal| author=Schwammenthal E, Vered Z, Moshkowitz Y, Rabinowitz B, Ziskind Z, Smolinski AK et al.| title=Dobutamine echocardiography in patients with aortic stenosis and left ventricular dysfunction: predicting outcome as a function of management strategy. | journal=Chest | year= 2001 | volume= 119 | issue= 6 | pages= 1766-77 | pmid=11399704 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11399704  }} </ref><ref name="pmid12835219">{{cite journal| author=Monin JL, Quéré JP, Monchi M, Petit H, Baleynaud S, Chauvel C et al.| title=Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics. | journal=Circulation | year= 2003 | volume= 108 | issue= 3 | pages= 319-24 | pmid=12835219 | doi=10.1161/01.CIR.0000079171.43055.46 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12835219  }} </ref><ref name="pmid12176952">{{cite journal| author=Nishimura RA, Grantham JA, Connolly HM, Schaff HV, Higano ST, Holmes DR| title=Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory. | journal=Circulation | year= 2002 | volume= 106 | issue= 7 | pages= 809-13 | pmid=12176952 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12176952  }} </ref><ref name="pmid12784780">{{cite journal| author=Zuppiroli A, Mori F, Olivotto I, Castelli G, Favilli S, Dolara A| title=Therapeutic implications of contractile reserve elicited by dobutamine echocardiography in symptomatic, low-gradient aortic stenosis. | journal=Ital Heart J | year= 2003 | volume= 4 | issue= 4 | pages= 264-70 | pmid=12784780 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12784780  }} </ref>
 * In pseudo-severe aortic stenosis, the aortic stenosis is '''mild or moderate''' and it co-exists with another myocardial disease that is independent from the aortic stenosis.  '''Overestimation''' of the severity of the aortic stenosis may happen in this context.
 * The presence of [[fibrosis]] in the [[left ventricle]] may cause an incomplete recovery after [[aortic valve replacement]].<ref name="pmid">{{cite journal |author=Carabello BA, Green LH, Grossman W, Cohn LH, Koster JK, Collins JJ |title= |journal=[[]] |volume= |issue= |pages=42–8 |year=1980 |month=July |pmid= |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7379284 |accessdate=2012-04-10}}</ref>
-*This scenario can also occur among patients in whom there is a history of [[myocardial infarction]] due to the absence of sufficient contractility to mount an aortic [[Intravascular pressure gradient|gradient]].
+*This scenario can also occur among patients in whom there is a history of [[myocardial infarction]] and insufficient contractility to mount an aortic [[Intravascular pressure gradient|gradient]].
-*It may also occur when myocardial fibrosis develops due to longstanding aortic stenosis.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
+*It may also occur when myocardial fibrosis develops due to longstanding aortic stenosis.
+<br>
 ===Low Flow, Low Gradient Aortic Stenosis with Normal Ejection Fraction===
-*  LF-LG AS with normal ejection fraction has been recently described. The normal [[ejection fraction]] might lead to an '''underestimation''' of the severity of the aortic stenosis; nevertheless, LF-LG aortic stenosis with normal LVEF is usually an '''advanced''' stage of valvular and myocardial diseases.
+LF-LG AS with normal ejection fraction has been recently described.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref><ref name="pmid17533183">{{cite journal| author=Hachicha Z, Dumesnil JG, Bogaty P, Pibarot P| title=Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival. | journal=Circulation | year= 2007 | volume= 115 | issue= 22 | pages= 2856-64 | pmid=17533183 | doi=10.1161/CIRCULATIONAHA.106.668681 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17533183  }} </ref><ref name="pmid19580719">{{cite journal| author=Cramariuc D, Cioffi G, Rieck AE, Devereux RB, Staal EM, Ray S et al.| title=Low-flow aortic stenosis in asymptomatic patients: valvular-arterial impedance and systolic function from the SEAS Substudy. | journal=JACC Cardiovasc Imaging | year= 2009 | volume= 2 | issue= 4 | pages= 390-9 | pmid=19580719 | doi=10.1016/j.jcmg.2008.12.021 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19580719  }} </ref><ref name="pmid22240128">{{cite journal| author=Lancellotti P, Magne J, Donal E, Davin L, O'Connor K, Rosca M et al.| title=Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification. | journal=J Am Coll Cardiol | year= 2012 | volume= 59 | issue= 3 | pages= 235-43 | pmid=22240128 | doi=10.1016/j.jacc.2011.08.072 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22240128  }} </ref>
-* LF-LG AS with normal ejection fraction has a lot of similarities with normal ejection fraction [[diastolic heart failure]]. In fact, it is usually present in older females in the context of systemic hypertension. The underlying pathophysiology is a restrictive myocardium.
+*  LF-LG aortic stenosis with normal LVEF is usually an '''advanced''' stage of valvular and myocardial diseases.  The normal [[ejection fraction]] might lead to an '''underestimation''' of the severity of the aortic stenosis.
-* The characteristics of LF-LG AS with normal ejection fraction is the presence of extensive remodeling due to predominant diastolic dysfunction as well as systolic dysfunction. However, the decrease in the systolic performance of the left ventricle does not show a decrease in the [[ejection fraction]].<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
+* LF-LG AS with normal ejection fraction has a lot of similarities with normal ejection fraction [[diastolic heart failure]]. In fact, it is usually present in older females and in the context of [[hypertension]]. The underlying pathophysiology of LF-LG AS with normal ejection fraction is a restrictive myocardium.
+* LF-LG AS with normal ejection fraction is characterized by the presence of extensive remodeling due to predominant diastolic dysfunction as well as systolic dysfunction.  However, the decrease in the systolic performance of the left ventricle does not contribute to a decrease in the [[ejection fraction]].
@@ Line 57: / Line 66: @@
 -Decreased compliance
 |Underestimation of the severity of aortic stenosis
-Differentiation from confounding measurement errors and small ventricle body size
+Confounding measurement errors and small ventricle body size
 |}
 ==Diagnosis==
-*[[Aortic stenosis echocardiography|Echocardiography]] is fairly accurate in the assessment of the severity of aortic stenosis in patients with normal or near normal [[cardiac output]]. However, [[Exercise stress testing#Exercise/Pharmacologic Stress Echocardiography|dobutamine stress echocardiography]] or [[Aortic stenosis cardiac catheterization|cardiac catheterization]] may be required to accurately assess the severity of aortic stenosis in patients with [[cardiac output|low output]] [[aortic stenosis]].
+*[[Aortic stenosis echocardiography|Echocardiography]] is fairly accurate in the assessment of the severity of aortic stenosis in patients with normal or near normal [[cardiac output]]. However, [[Exercise stress testing#Exercise/Pharmacologic Stress Echocardiography|dobutamine stress echocardiography]] or [[Aortic stenosis cardiac catheterization|cardiac catheterization]] may be required to accurately assess the severity of aortic stenosis in patients with [[cardiac output|low output]] [[aortic stenosis]].<ref name="pmid12835219">{{cite journal| author=Monin JL, Quéré JP, Monchi M, Petit H, Baleynaud S, Chauvel C et al.| title=Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics. | journal=Circulation | year= 2003 | volume= 108 | issue= 3 | pages= 319-24 | pmid=12835219 | doi=10.1161/01.CIR.0000079171.43055.46 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12835219  }} </ref><ref name="pmid22240128">{{cite journal| author=Lancellotti P, Magne J, Donal E, Davin L, O'Connor K, Rosca M et al.| title=Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification. | journal=J Am Coll Cardiol | year= 2012 | volume= 59 | issue= 3 | pages= 235-43 | pmid=22240128 | doi=10.1016/j.jacc.2011.08.072 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22240128  }} </ref>
 ===Low Dose Dobutamine Stress Echocardiography===
-*Low dose (<20 microgram/Kg/min) [[dobutamine stress echocardiography]] allows:
+*Low dose (<20 microgram/Kg/min) [[dobutamine stress echocardiography]] allows:<ref name="pmid7810504">{{cite journal| author=deFilippi CR, Willett DL, Brickner ME, Appleton CP, Yancy CW, Eichhorn EJ et al.| title=Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. | journal=Am J Cardiol | year= 1995 | volume= 75 | issue= 2 | pages= 191-4 | pmid=7810504 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7810504  }} </ref><ref name="pmid12176952">{{cite journal| author=Nishimura RA, Grantham JA, Connolly HM, Schaff HV, Higano ST, Holmes DR| title=Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory. | journal=Circulation | year= 2002 | volume= 106 | issue= 7 | pages= 809-13 | pmid=12176952 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12176952  }} </ref>
-** '''The differentiation between severe and pseudo-severe low flow low gradient aortic stenosis''' through the degree of change of both the [[aortic valve area|effective orifice area]] and  the transvalvular gradient after dobutamine infusion. Changes following dobutamine infusion are due to the fact that dobutamine causes increase in the flow across the [[aortic valve]].
+**'''The differentiation between severe and pseudo-severe low flow low gradient aortic stenosis''' through the degree of change of both the [[aortic valve area|effective orifice area]] and  the transvalvular gradient after dobutamine infusion. Changes following dobutamine infusion are due to the fact that dobutamine causes increase in the flow across the [[aortic valve]].
 ***In pseudosevere aortic stenosis, there is increase in the [[aortic valve area|effective orifice area]] of the [[aortic valve]], in a way that it is larger than 1.2 cm2, and slight increase in the gradient, in a way that is inferior to 40 mmHg.
 ***In severe aortic stenosis, there is absence or little increase in the [[aortic valve area|effective orifice area]] of the [[aortic valve]], in a way that is inferior to 1.2 cm2, and increase in the gradient to become greater than 40 mmHg.
@@ Line 72: / Line 81: @@
 ***The [[aortic valve area]] should increase to more than  1-1.2 cm2 with a dobutamine infusion and the [[Intravascular pressure gradient|mean pressure gradient]] should rise above 30 mm Hg. While early surgical mortality is 32-33% in patients who fail to to achieve these improvements with dobutamine infusions, it is only 5–7% in patients who demonstrate an increase in their contractility and gradient. Five years survival after surgery was 88% in patients with improved contractility and only 10–25% in patients with unimproved contractility.
-;Shown below is an algorithm summarizing the interpretation of the results of low dose dobutamine stress echocardiography in the evaluation of low flow, low gradient aortic stenosis.
+;Shown below is an algorithm summarizing the interpretation of the results of low dose dobutamine stress echocardiography in the evaluation of low flow, low gradient aortic stenosis.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
-[[Image:Diagnosis_of_LGLFAS.png‎|center|500px|Evaluation of low flow, low gradient aortic stenosis by low dose dobutamine stress echocardiography]]
+<span style="font-size:85%">'''Abbreviations:''' '''EOA:''' Effective orifice area; '''ΔP<sub>mean</sub>:''' mean pressure gradient</span>
+{{familytree/start}}
+{{familytree | | | A01 | | | | | | boxstyle=background: WhiteSmoke| A01= '''Ultrasound evaluation of aortic stenosis'''<br> Effective orifice area (EOA)≤ 1 cm<sup>2</sup><br> Pressure gradient (ΔP)<40 mmHg}}
+{{familytree | | | |!| | | | | | | }}
+{{familytree | | | B01 | | | | | boxstyle=background: WhiteSmoke| B01= '''Low grade low flow aortic stenosis'''}}
+{{familytree | |,|-|^|-|.| | | | | }}
+{{familytree | C01 | | C02 | | | boxstyle=background: WhiteSmoke| C01= Normal left ventricular ejection fraction| C02= Left ventricular ejection fraction≤ 40-50%}}
+{{familytree | | | | | |!| | | | | }}
+{{familytree | | | | | D01 | | | boxstyle=background: WhiteSmoke| D01= '''Dobutamine stress test'''}}
+{{familytree | | | |,|-|^|-|.| | | }}
+{{familytree | | | E01 | | E02 | boxstyle=background: WhiteSmoke| E01= Increase in stroke volume by ≥ 20%| E02= Increase in stroke volume by <20%}}
+{{familytree | | | |!| | | |!| | | }}
+{{familytree | | | F01 | | F02 | boxstyle=background: WhiteSmoke| F01= Presence of left ventricular flow reserve| F02= Absence of left ventricular flow reserve}}
+{{familytree | |,|-|^|.| |,|^|-|.| }}
+{{familytree | G01 | | G02 | | G03 | boxstyle=background: WhiteSmoke| G01= ΔP≥40 <br> EOA<1-1.2| G02= ΔP<40 <br> EOA≥1-1.2| G03= EOA<1-1.2}}
+{{familytree | |!| | | |!| | | |!| | }}
+{{familytree | H01 | | H02 | | H03 | boxstyle=background: LightCoral | H01= '''True severe aortic stenosis'''| H02= '''Pseudo-severe aortic stenosis'''| H03= '''True severe aortic stenosis'''}}
+{{familytree/end}}
+<br>
 ==Treatment==
 ===Surgical and Medical Treatment===
-[[Aortic valve replacement]] is the treatment of choice for [[aortic stenosis]]. Given the associated operative risks with aortic valve replacement (AVR), true severe low flow low gradient aortic stenosis must be differentiated from pseudoaortic stenosis as the former benefit from AVR and the latter does not necessarily benefit from AVR. In addition, in case of [[low flow low gradient aortic stenosis with low ejection fraction]], the presence or absence of reserve flow dictates the treatment plan as the operative mortality increases in the absence of reserve flow. As low flow low gradient aortic stenosis with normal ejection fraction is a newly described entity, there is no yet clear recommendations for the management.
+[[Aortic valve replacement]] is the treatment of choice for [[aortic stenosis]].<ref name="pmid19021976">{{cite journal| author=Pai RG, Varadarajan P, Razzouk A| title=Survival benefit of aortic valve replacement in patients with severe aortic stenosis with low ejection fraction and low gradient with normal ejection fraction. | journal=Ann Thorac Surg | year= 2008 | volume= 86 | issue= 6 | pages= 1781-9 | pmid=19021976 | doi=10.1016/j.athoracsur.2008.08.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19021976  }} </ref><ref name="pmid21619977">{{cite journal| author=Tarantini G, Covolo E, Razzolini R, Bilato C, Frigo AC, Napodano M et al.| title=Valve replacement for severe aortic stenosis with low transvalvular gradient and left ventricular ejection fraction exceeding 0.50. | journal=Ann Thorac Surg | year= 2011 | volume= 91 | issue= 6 | pages= 1808-15 | pmid=21619977 | doi=10.1016/j.athoracsur.2011.02.057 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21619977  }} </ref>Given the associated operative risks with aortic valve replacement (AVR), true severe low flow low gradient aortic stenosis must be differentiated from pseudoaortic stenosis as the former benefit from AVR and the latter does not necessarily benefit from AVR. In addition, in case of [[low flow low gradient aortic stenosis with low ejection fraction]], the presence or absence of reserve flow dictates the treatment plan as the operative mortality increases in the absence of reserve flow. As low flow low gradient aortic stenosis with normal ejection fraction is a newly described entity, there is no yet clear recommendations for the management.<ref name="pmid19729117">{{cite journal| author=Hachicha Z, Dumesnil JG, Pibarot P| title=Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis. | journal=J Am Coll Cardiol | year= 2009 | volume= 54 | issue= 11 | pages= 1003-11 | pmid=19729117 | doi=10.1016/j.jacc.2009.04.079 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19729117  }} </ref><ref name="pmid22336754">{{cite journal| author=Malouf J, Le Tourneau T, Pellikka P, Sundt TM, Scott C, Schaff HV et al.| title=Aortic valve stenosis in community medical practice: determinants of outcome and implications for aortic valve replacement. | journal=J Thorac Cardiovasc Surg | year= 2012 | volume= 144 | issue= 6 | pages= 1421-7 | pmid=22336754 | doi=10.1016/j.jtcvs.2011.09.075 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22336754  }} </ref><ref name="pmid21323995">{{cite journal| author=Belkin RN, Khalique O, Aronow WS, Ahn C, Sharma M| title=Outcomes and survival with aortic valve replacement compared with medical therapy in patients with low-, moderate-, and severe-gradient severe aortic stenosis and normal left ventricular ejection fraction. | journal=Echocardiography | year= 2011 | volume= 28 | issue= 4 | pages= 378-87 | pmid=21323995 | doi=10.1111/j.1540-8175.2010.01372.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21323995  }} </ref>
-;Shown below is an algorithm of the management of low flow, low gradient aortic stenosis.
-[[Image:Management_of_LGLFAS.png|center|500px|Management of low flow, low gradient aortic stenosis]]
+;Shown below is an algorithm of the management of low flow, low gradient aortic stenosis.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
+<span style="font-size:85%">'''Abbreviations:''' '''AVR:''' [[Aortic valve replacement]]; '''EOA:''' Effective orifice area; '''ΔP<sub>mean</sub>:''' mean pressure gradient</span>
+{{familytree/start}}
+{{familytree | | | B01 | | | | | boxstyle=background: WhiteSmoke| B01= '''Low grade low flow aortic stenosis'''}}
+{{familytree | |,|-|^|-|.| | | | | }}
+{{familytree | C01 | | C02 | | | boxstyle=background: WhiteSmoke| C01= Normal left ventricular ejection fraction| C02= Left ventricular ejection fraction≤ 40-50%}}
+{{familytree | |!| | | |!| | | | }}
+{{familytree | C03 | | |!| | | | boxstyle=background: LightSkyBlue| C03= '''No specific recommendations:''' <br>'''- Surgical [[aortic valve replacement|AVR]], or''' <br>'''- Transcather AVR, or''' <br> '''- Medical treatment'''}}
+{{familytree | | | | | D01 | | | boxstyle=background: WhiteSmoke| D01= '''[[Dobutamine stress test]]'''}}
+{{familytree | | | |,|-|^|-|.| | | }}
+{{familytree | | | E01 | | E02 | boxstyle=background: WhiteSmoke| E01= Increase in [[stroke volume]] by ≥ 20%| E02= Increase in [[stroke volume]] by <20%}}
+{{familytree | |,|-|^|.| |,|^|-|.| }}
+{{familytree | G01 | | G02 | | G03 | boxstyle=background: WhiteSmoke| G01= ΔP≥40 <br> EOA<1-1.2| G02= ΔP<40 <br> EOA≥1-1.2| G03= EOA<1-1.2}}
+{{familytree | |!| | | |!| | | |!| | }}
+{{familytree | H01 | | H02 | | H03 | boxstyle=background: LightCoral | H01= '''True severe aortic stenosis'''| H02= '''Pseudo-severe aortic stenosis'''| H03= '''True severe aortic stenosis'''}}
+{{familytree | |!| | | |!| | | |!| | }}
+{{familytree | I01 | | I02 | | I03 |boxstyle=background: LightSkyBlue| I01= '''Surgical AVR''' <br>'''with/without [[CABG]]'''| I02= '''Medical treatment'''<br> '''Close follow up'''| I03= '''Transcather AVR'''}}
+{{familytree/end}}
+<br>
 ===Operative Mortality Risk Factors===
-The risk factors for operative mortality in the case of low flow, low gradient aortic stenosis with low ventricle ejection fraction are:
+The risk factors for operative mortality in the case of low flow, low gradient aortic stenosis with low ventricle ejection fraction are:<ref name="pmid10779460">{{cite journal| author=Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO et al.| title=Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients. | journal=Circulation | year= 2000 | volume= 101 | issue= 16 | pages= 1940-6 | pmid=10779460 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10779460  }} </ref><ref name="pmid16162627">{{cite journal| author=Vaquette B, Corbineau H, Laurent M, Lelong B, Langanay T, de Place C et al.| title=Valve replacement in patients with critical aortic stenosis and depressed left ventricular function: predictors of operative risk, left ventricular function recovery, and long term outcome. | journal=Heart | year= 2005 | volume= 91 | issue= 10 | pages= 1324-9 | pmid=16162627 | doi=10.1136/hrt.2004.044099 | pmc=PMC1769144 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16162627  }} </ref>
 *Absence of [[left ventricle]] flow reserve
-*Decreased pre-operative mean transvalvular gradient below 20mmHg at rest<ref name="pmid10779460">{{cite journal| author=Connolly HM, Oh JK, Schaff HV, Roger VL, Osborn SL, Hodge DO et al.| title=Severe aortic stenosis with low transvalvular gradient and severe left ventricular dysfunction:result of aortic valve replacement in 52 patients. | journal=Circulation | year= 2000 | volume= 101 | issue= 16 | pages= 1940-6 | pmid=10779460 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10779460  }} </ref>
+*Decreased pre-operative mean transvalvular gradient below 20mmHg at rest
-*[[Coronary artery disease]] involving several vessels<ref name="pmid16162627">{{cite journal| author=Vaquette B, Corbineau H, Laurent M, Lelong B, Langanay T, de Place C et al.| title=Valve replacement in patients with critical aortic stenosis and depressed left ventricular function: predictors of operative risk, left ventricular function recovery, and long term outcome. | journal=Heart | year= 2005 | volume= 91 | issue= 10 | pages= 1324-9 | pmid=16162627 | doi=10.1136/hrt.2004.044099 | pmc=PMC1769144 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16162627  }} </ref>
+*[[Coronary artery disease]] involving several vessels
-===Survival===
+==ACC/AHA Guidelines<ref name="pmid18848134">{{cite journal| author=Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD et al.| title=2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. | journal=J Am Coll Cardiol | year= 2008 | volume= 52 | issue= 13 | pages= e1-142 | pmid=18848134 | doi=10.1016/j.jacc.2008.05.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18848134  }} </ref>==
-; Shown below is a graph showing the survival (after 100-120 months follow up) of patients with low flow low gradient aortic stenosis following medical treatment and surgical intervention.<ref name="pmid23062546">{{cite journal| author=Pibarot P, Dumesnil JG| title=Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. | journal=J Am Coll Cardiol | year= 2012 | volume= 60 | issue= 19 | pages= 1845-53 | pmid=23062546 | doi=10.1016/j.jacc.2012.06.051 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23062546  }} </ref>
-[[Image:Survival_LFLG.png‎|center|500px|Survival of patients with low flow, low gradient aortic stenosis following medical or surgical treatment.]]
-==ACC/AHA Guidelines<ref name="pmid18848134">{{cite journal| author=Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD et al.| title=2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. | journal=J Am Coll Cardiol | year= 2008 | volume= 52 | issue= 13 | pages= e1-142 | pmid=18848134 | doi=10.1016/j.jacc.2008.05.007 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18848134  }} </ref>==
 ===Dobutamine Stress Echocardiography===
@@ Line 102: / Line 148: @@
 | bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''2.'''[[Aortic stenosis cardiac catheterization|Cardiac catheterization]] for hemodynamic measurements with infusion of [[dobutamine]] can be useful for evaluation of patients with low-flow/low-gradient [[aortic stenosis]] and [[left ventricular dysfunction]]. ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])'' <nowiki>"</nowiki>
 |}
 ==References==

Low flow, low gradient aortic stenosis: Difference between revisions

Latest revision as of 17:03, 6 December 2016

Overview

Epidemiology

Pathophysiology

Low Flow, Low Gradient Aortic Stenosis with Low Ejection Fraction

True severe aortic stenosis:

Pseudo-severe aortic stenosis:

Low Flow, Low Gradient Aortic Stenosis with Normal Ejection Fraction

Diagnosis

Low Dose Dobutamine Stress Echocardiography

Treatment

Surgical and Medical Treatment

Operative Mortality Risk Factors

ACC/AHA Guidelines[1]

Dobutamine Stress Echocardiography

References

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ACC/AHA Guidelines^[1]