LTBP1 (gene): Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
imported>Bibcode Bot m (Adding 0 arxiv eprint(s), 1 bibcode(s) and 0 doi(s). Did it miss something? Report bugs, errors, and suggestions at User talk:Bibcode Bot) |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | |||
{{ | '''Latent-transforming growth factor beta-binding protein 1''' is a [[protein]] that in humans is encoded by the ''LTBP1'' [[gene]].<ref name="pmid2350783">{{cite journal |vauthors=Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH | title = TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences | journal = Cell | volume = 61 | issue = 6 | pages = 1051–1061 |date=July 1990 | pmid = 2350783 | pmc = | doi =10.1016/0092-8674(90)90069-Q }}</ref><ref name="pmid11104663">{{cite journal |vauthors=Oklu R, Hesketh R | title = The latent transforming growth factor beta binding protein (LTBP) family | journal = Biochem J | volume = 352 | issue = 3| pages = 601–10 |date=January 2001 | pmid = 11104663 | pmc = 1221494 | doi = 10.1042/0264-6021:3520601}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4052| accessdate = }}</ref> | ||
}} | |||
| | |||
| | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" | | summary_text = The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
LTBP1 (gene) has been shown to [[Protein-protein interaction|interact]] with [[TGF beta 1]].<ref name=pmid10930463>{{cite journal |last=Saharinen |first=J |authorlink= |author2=Keski-Oja J |date=August 2000 |title=Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta |journal=Mol. Biol. Cell |volume=11 |issue=8 |pages=2691–704 |publisher= |location = UNITED STATES| issn = 1059-1524| pmid = 10930463 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=14949 | doi=10.1091/mbc.11.8.2691}}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J |title=Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 2 |pages= 99–117 |year= 2000 |pmid= 10743502 |doi=10.1016/S1359-6101(99)00010-6 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Keski-Oja J, Koli K, von Melchner H |title=TGF-beta activation by traction? |journal=Trends Cell Biol. |volume=14 |issue= 12 |pages= 657–659 |year= 2005 |pmid= 15564041 |doi= 10.1016/j.tcb.2004.10.003 }} | ||
*{{cite journal | author= | *{{cite journal | author=Stenman G |title=Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12→q22 |journal=Cytogenet. Cell Genet. |volume=66 |issue= 2 |pages= 117–119 |year= 1994 |pmid= 8287682 |doi=10.1159/000133680 |name-list-format=vanc| author2=Sahlin P | author3=Olofsson A | display-authors=3 | last4=Van Kessel | first4=Geurts | last5=Miyazono | first5=K. }} | ||
*{{cite journal | author=Olofsson A |title=Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 31294–31297 |year= 1996 |pmid= 8537398 |doi=10.1074/jbc.270.52.31294 |name-list-format=vanc| author2=Ichijo H | author3=Morén A | display-authors=3 | last4=Ten Dijke | first4=P | last5=Miyazono | first5=K | last6=Heldin | first6=CH }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Saharinen J, Taipale J, Keski-Oja J |title=Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1 |journal=EMBO J. |volume=15 |issue= 2 |pages= 245–53 |year= 1996 |pmid= 8617200 |doi= | pmc=449939 }} | ||
*{{cite journal |vauthors=Taipale J, Saharinen J, Hedman K, Keski-Oja J |title=Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils |journal=J. Histochem. Cytochem. |volume=44 |issue= 8 |pages= 875–89 |year= 1996 |pmid= 8756760 |doi=10.1177/44.8.8756760 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Nunes I, Gleizes PE, Metz CN, Rifkin DB |title=Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta |journal=J. Cell Biol. |volume=136 |issue= 5 |pages= 1151–1163 |year= 1997 |pmid= 9060478 |doi=10.1083/jcb.136.5.1151 | pmc=2132473 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Karonen T, Jeskanen L, Keski-Oja J |title=Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma |journal=Br. J. Dermatol. |volume=137 |issue= 1 |pages= 51–58 |year= 1997 |pmid= 9274625 |doi=10.1111/j.1365-2133.1997.tb03700.x }} | ||
*{{cite journal | | *{{cite journal | author=Dallas SL |title=Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo |journal=J. Bone Miner. Res. |volume=15 |issue= 1 |pages= 68–81 |year= 2000 |pmid= 10646116 |doi=10.1359/jbmr.2000.15.1.68 |name-list-format=vanc| author2=Keene DR | author3=Bruder SP | display-authors=3 | last4=Saharinen | first4=Juha | last5=Sakai | first5=Lynn Y. | last6=Mundy | first6=Gregory R. | last7=Bonewald | first7=Lynda F. }} | ||
*{{cite journal | | *{{cite journal |vauthors=Saharinen J, Keski-Oja J |title=Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta |journal=Mol. Biol. Cell |volume=11 |issue= 8 |pages= 2691–704 |year= 2000 |pmid= 10930463 |doi= 10.1091/mbc.11.8.2691| pmc=14949 }} | ||
*{{cite journal | author=Dallas SL | *{{cite journal |vauthors=Ludbrook SB, Barry ST, Delves CJ, Horgan CM |title=The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 |journal=Biochem. J. |volume=369 |issue= Pt 2 |pages= 311–8 |year= 2003 |pmid= 12358597 |doi= 10.1042/BJ20020809 | pmc=1223078 }} | ||
*{{cite journal | author=Isogai Z |title=Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2750–2757 |year= 2003 |pmid= 12429738 |doi= 10.1074/jbc.M209256200 |name-list-format=vanc| author2=Ono RN | author3=Ushiro S | display-authors=3 | last4=Keene | first4=DR | last5=Chen | first5=Y | last6=Mazzieri | first6=R | last7=Charbonneau | first7=NL | last8=Reinhardt | first8=DP | last9=Rifkin | first9=DB }} | |||
*{{cite journal | | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | | *{{cite journal |vauthors=Gui Y, Murphy LJ |title=Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1 |journal=Mol. Cell. Biochem. |volume=250 |issue= 1–2 |pages= 189–195 |year= 2004 |pmid= 12962157 |doi=10.1023/A:1024990409102 }} | ||
*{{cite journal | author= | *{{cite journal |vauthors=Weikkolainen K, Keski-Oja J, Koli K |title=Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts |journal=Growth Factors |volume=21 |issue= 2 |pages= 51–60 |year= 2004 |pmid= 14626352 |doi=10.1080/08977198310001598778 }} | ||
*{{cite journal | author=Shariat SF |title=Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression |journal=Clin. Cancer Res. |volume=10 |issue= 6 |pages= 1992–1999 |year= 2004 |pmid= 15041717 |doi=10.1158/1078-0432.CCR-0768-03 |name-list-format=vanc| author2=Kattan MW | author3=Traxel E | display-authors=3 | last4=Andrews | first4=B | last5=Zhu | first5=K | last6=Wheeler | first6=TM | last7=Slawin | first7=KM }} | |||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=4052}} | |||
{{TGFβ receptor superfamily modulators}} | |||
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | |||
{{PBB_Controls | |||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{ | {{gene-2-stub}} | ||
Latest revision as of 18:38, 24 June 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.[1][2][3]
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
Interactions
LTBP1 (gene) has been shown to interact with TGF beta 1.[4]
References
- ↑ Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH (July 1990). "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences". Cell. 61 (6): 1051–1061. doi:10.1016/0092-8674(90)90069-Q. PMID 2350783.
- ↑ Oklu R, Hesketh R (January 2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem J. 352 (3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
- ↑ 3.0 3.1 "Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1".
- ↑ Saharinen, J; Keski-Oja J (August 2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. UNITED STATES. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. ISSN 1059-1524. PMC 14949. PMID 10930463.
Further reading
- Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
- Keski-Oja J, Koli K, von Melchner H (2005). "TGF-beta activation by traction?". Trends Cell Biol. 14 (12): 657–659. doi:10.1016/j.tcb.2004.10.003. PMID 15564041.
- Stenman G, Sahlin P, Olofsson A, et al. (1994). "Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12→q22". Cytogenet. Cell Genet. 66 (2): 117–119. doi:10.1159/000133680. PMID 8287682.
- Olofsson A, Ichijo H, Morén A, et al. (1996). "Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix". J. Biol. Chem. 270 (52): 31294–31297. doi:10.1074/jbc.270.52.31294. PMID 8537398.
- Saharinen J, Taipale J, Keski-Oja J (1996). "Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1". EMBO J. 15 (2): 245–53. PMC 449939. PMID 8617200.
- Taipale J, Saharinen J, Hedman K, Keski-Oja J (1996). "Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils". J. Histochem. Cytochem. 44 (8): 875–89. doi:10.1177/44.8.8756760. PMID 8756760.
- Nunes I, Gleizes PE, Metz CN, Rifkin DB (1997). "Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta". J. Cell Biol. 136 (5): 1151–1163. doi:10.1083/jcb.136.5.1151. PMC 2132473. PMID 9060478.
- Karonen T, Jeskanen L, Keski-Oja J (1997). "Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma". Br. J. Dermatol. 137 (1): 51–58. doi:10.1111/j.1365-2133.1997.tb03700.x. PMID 9274625.
- Dallas SL, Keene DR, Bruder SP, et al. (2000). "Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo". J. Bone Miner. Res. 15 (1): 68–81. doi:10.1359/jbmr.2000.15.1.68. PMID 10646116.
- Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
- Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3". Biochem. J. 369 (Pt 2): 311–8. doi:10.1042/BJ20020809. PMC 1223078. PMID 12358597.
- Isogai Z, Ono RN, Ushiro S, et al. (2003). "Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein". J. Biol. Chem. 278 (4): 2750–2757. doi:10.1074/jbc.M209256200. PMID 12429738.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gui Y, Murphy LJ (2004). "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". Mol. Cell. Biochem. 250 (1–2): 189–195. doi:10.1023/A:1024990409102. PMID 12962157.
- Weikkolainen K, Keski-Oja J, Koli K (2004). "Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts". Growth Factors. 21 (2): 51–60. doi:10.1080/08977198310001598778. PMID 14626352.
- Shariat SF, Kattan MW, Traxel E, et al. (2004). "Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression". Clin. Cancer Res. 10 (6): 1992–1999. doi:10.1158/1078-0432.CCR-0768-03. PMID 15041717.
 | This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |