Guanethidine: Difference between revisions
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| IUPAC_name = 2-(2-azocan-1-ylethyl)guanidine | | IUPAC_name = 2-(2-azocan-1-ylethyl)guanidine | ||
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'''For patient information, click [[Guanethidine (patient information)|here]]'''. | |||
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{{CMG}} | {{CMG}} | ||
==Overview== | |||
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'''Guanethidine''' is an [[antihypertensive]] drug that reduces the release of [[catecholamines]], such as noradrenaline. Its mechanism is inhibition of the [[Mg++ATPase dependent pump]]. Side effects include orthostatic and exercise hypotension, sexual dysfunction, and diarrhea. | '''Guanethidine''' is an [[antihypertensive]] drug that reduces the release of [[catecholamines]], such as noradrenaline. Its mechanism is inhibition of the [[Mg++ATPase dependent pump]]. Side effects include orthostatic and exercise hypotension, sexual dysfunction, and diarrhea. | ||
It is no longer available in the US due to side effects and because substantially better drugs are available. It is still licensed in some countries, e.g. UK, for the rapid control of blood pressure in a [[hypertensive emergency]]. | It is no longer available in the US due to side effects and because substantially better drugs are available. It is still licensed in some countries, e.g. UK, for the rapid control of blood pressure in a [[hypertensive emergency]]. | ||
{{Antihypertensives and diuretics}} | {{Antihypertensives and diuretics}} | ||
{{Antiglaucoma preparations and miotics}} | {{Antiglaucoma preparations and miotics}} | ||
[[Category:Cardiovascular Drugs]] | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 18:24, 27 June 2014
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| Clinical data | |
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| ATC code | |
| Pharmacokinetic data | |
| Elimination half-life | 1.5 days |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C10H22N4 |
| Molar mass | 198.309 g/mol |
For patient information, click here.
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WikiDoc Resources for Guanethidine |
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Most recent articles on Guanethidine Most cited articles on Guanethidine |
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Powerpoint slides on Guanethidine |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on Guanethidine at Clinical Trials.gov Clinical Trials on Guanethidine at Google
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US National Guidelines Clearinghouse on Guanethidine
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Patient resources on Guanethidine Discussion groups on Guanethidine Patient Handouts on Guanethidine Directions to Hospitals Treating Guanethidine Risk calculators and risk factors for Guanethidine
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Causes & Risk Factors for Guanethidine |
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Continuing Medical Education (CME) |
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International |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as noradrenaline. Its mechanism is inhibition of the Mg++ATPase dependent pump. Side effects include orthostatic and exercise hypotension, sexual dysfunction, and diarrhea.
It is no longer available in the US due to side effects and because substantially better drugs are available. It is still licensed in some countries, e.g. UK, for the rapid control of blood pressure in a hypertensive emergency.
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Cardiovascular Drugs
- Drugs