Drug allergy classification: Difference between revisions
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==Classification Based on Reaction Type== | ==Classification Based on Reaction Type== | ||
One type of [[classification]] of drug allergies, is based on the type of [[autoimmune]] process. This is the same type of classification that is used for other types of [[immunological]] reactions, and is based on the Gell and Coombs system. | One type of [[classification]] of drug allergies, is based on the type of [[autoimmune]] process. This is the same type of classification that is used for other types of [[immunological]] reactions, and is based on the Gell and Coombs system. Drugs usually cause type III and type IV reactions, however certain medications such as penecillin, can cause all four. | ||
*[[Type I hypersensitivity reaction]]: Immediate onset and primarily caused by the [[IgE]], [[basophils]], and [[degranulation]] of mast cells. | *[[Type I hypersensitivity reaction]]: Immediate onset and primarily caused by the [[IgE]], [[basophils]], and [[degranulation]] of mast cells. | ||
*Type II hypersensitivity reaction: Delayed onset reaction caused by [[antibodies]], mediated by [[IgG]] mediated destruction of cells. | *Type II hypersensitivity reaction: Delayed onset reaction caused by [[antibodies]], mediated by [[IgG]] mediated destruction of cells. | ||
*Type III hypersensitivity reaction: Delayed in onset and caused by IgG [[immune complex]] formation and deposition, and [[complement]] activation. | *Type III hypersensitivity reaction: Delayed in onset and caused by IgG [[immune complex]] formation and deposition, and [[complement]] activation. | ||
*Type IV hypersensitivity reaction: [[T-cell]] mediated delayed onset reaction. | *Type IV hypersensitivity reaction: [[T-cell]] mediated delayed onset reaction. |
Revision as of 16:40, 13 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]
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Classification Based on Reaction Type
One type of classification of drug allergies, is based on the type of autoimmune process. This is the same type of classification that is used for other types of immunological reactions, and is based on the Gell and Coombs system. Drugs usually cause type III and type IV reactions, however certain medications such as penecillin, can cause all four.
- Type I hypersensitivity reaction: Immediate onset and primarily caused by the IgE, basophils, and degranulation of mast cells.
- Type II hypersensitivity reaction: Delayed onset reaction caused by antibodies, mediated by IgG mediated destruction of cells.
- Type III hypersensitivity reaction: Delayed in onset and caused by IgG immune complex formation and deposition, and complement activation.
- Type IV hypersensitivity reaction: T-cell mediated delayed onset reaction.