DNA damage response element gene transcriptions

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Associate Editor(s)-in-Chief: Henry A. Hoff

"The corepressor complex is recruited to the RNR genes by the sequence-specific DNA-binding protein Crt1, which recognizes the DNA damage response elements (DREs) in the upstream repression sequence (URS) (19, 35)."[1]

Human genes

Consensus sequences

"A consensus sequence, 5'-TAGCCGCCGRRRR-3' (where R = an unspecified purine nucleoside [A/G],was generated from these data."[2]

DNA damage response element (DRE) has the consensus sequence TTTCAAT.[3]

Samplings

Copying the consensus URS: 5'-TAGCCGCCG-3' and putting the sequence in "⌘F" finds no locations between ZNF497 and A1BG or between ZSCAN22 and A1BG as can be found by the computer programs.

See also

References

  1. Zhengjian Zhang and Joseph C. Reese (17 September 2004). "Redundant Mechanisms Are Used by Ssn6-Tup1 in Repressing Chromosomal Gene Transcription in Saccharomyces cerevisiae". The Journal of Biological Chemistry. 279 (38): 39240–39250. doi:10.1074/jbc.M407159200. PMID 15254041. Retrieved 4 September 2020.
  2. Roberta A. Sumrada and Terrance G. Cooper (June 1987). "Ubiquitous upstream repression sequences control activation of the inducible arginase gene in yeast" (PDF). Proceedings of the National Academy of Sciences USA. 84: 3997–4001. doi:10.1073/pnas.84.12.3997. PMID 3295874. Retrieved 6 September 2020.
  3. Joshua J. Smith, Eric S. Cole, Daniel P. Romero (15 July 2004). "Transcriptional control of RAD51 expression in the ciliate Tetrahymena thermophila". Nucleic Acids Research. 32 (14): 4313–4321. doi:10.1093/nar/gkh771. PMID 15304567. Retrieved 4 September 2020.

External links