Clubbing

Clubbing
Clubbing in the fingers of a 33-year old female with pulmonary hypertension.
ICD-10	R68.3
ICD-9	781.5

WikiDoc Resources for Clubbing
Articles
Most recent articles on Clubbing Most cited articles on Clubbing Review articles on Clubbing Articles on Clubbing in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Clubbing Images of Clubbing Photos of Clubbing Podcasts & MP3s on Clubbing Videos on Clubbing
Evidence Based Medicine
Cochrane Collaboration on Clubbing Bandolier on Clubbing TRIP on Clubbing
Clinical Trials
Ongoing Trials on Clubbing at Clinical Trials.gov Trial results on Clubbing Clinical Trials on Clubbing at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Clubbing NICE Guidance on Clubbing NHS PRODIGY Guidance FDA on Clubbing CDC on Clubbing
Books
Books on Clubbing
News
Clubbing in the news Be alerted to news on Clubbing News trends on Clubbing
Commentary
Blogs on Clubbing
Definitions
Definitions of Clubbing
Patient Resources / Community
Patient resources on Clubbing Discussion groups on Clubbing Patient Handouts on Clubbing Directions to Hospitals Treating Clubbing Risk calculators and risk factors for Clubbing
Healthcare Provider Resources
Symptoms of Clubbing Causes & Risk Factors for Clubbing Diagnostic studies for Clubbing Treatment of Clubbing
Continuing Medical Education (CME)
CME Programs on Clubbing
International
Clubbing en Espanol Clubbing en Francais
Business
Clubbing in the Marketplace Patents on Clubbing
Experimental / Informatics
List of terms related to Clubbing

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: John Fani Srour, M.D.

Synonyms and keywords: Digital clubbing; Hippocratic fingers; drumstick fingers; watch glass nails; finger clubbing

Overview

In medicine clubbing is a deformity of the fingers and fingernails that is associated with a number of diseases, mostly of the heart and lungs. Idiopathic clubbing can also occur.

Historical Perspective

Hippocrates was probably the first to document clubbing as a sign of disease, and the phenomenon is therefore occasionally called Hippocratic fingers.

Pathophysiology

The exact cause for sporadic clubbing is unknown, and there are numerous theories as to its cause. Vasodilation (distended blood vessels), secretion of growth factors (such as platelet-derived growth factor and hepatocyte growth factor) from the lungs, and other mechanisms have been proposed. The discovery of disorders in the prostaglandin metabolism in primary osteo-arthropathy has led to suggestions that overproduction of PGE2 by other tissues may be the causative factor for clubbing.

Associated Conditions

Although many diseases are associated with clubbing such as oxygen deprivation and lung, heart, or liver disease, the reports are fairly anecdotal. Prospective studies of patients presenting with clubbing have not yet been performed, and hence there is no conclusive evidence of these associations.

• Lung disease:
  • Lung cancer, mainly large-cell (35% of all cases), not seen frequently in small cell lung cancer
  • Interstitial lung disease
  • Tuberculosis
  • Bronchiectasis
  • Suppurative lung disease: lung abscess, empyema
  • Cystic fibrosis
  • Pulmonary hypertension
  • Mesothelioma
  • It is worth noting that clubbing is not associated with chronic obstructive pulmonary disease (COPD). Indeed, the presence of clubbing in a patient with COPD should prompt a search for an underlying (lung) cancer.
• Heart disease:
  • Any disease featuring chronic hypoxia
  • Congenital cyanotic heart disease (most common cardiac cause)
  • Subacute bacterial endocarditis
  • Atrial myxoma (benign tumor)
• Gastrointestinal and hepatobiliary:
  • Malabsorption
  • Crohn's disease and ulcerative colitis
  • Cirrhosis, especially in primary biliary cirrhosis
  • Other liver diseases (in the "hepatopulmonary syndrome", a complication of cirrhosis)
• Others:
  • Hyperthyroidism (thyroid acropachy)
  • Familial and racial clubbing and "pseudoclubbing" (people of African descent often have what appears to be clubbing)
  • Vascular anomalies of the affected arm such as an axillary artery aneurysm (in unilateral clubbing)
• HPOA
  • A special form of clubbing is hypertrophic pulmonary osteo-arthropathy, known in continental Europe as Pierre Marie-Bamberger syndrome. (In dogs the condition is known as hypertrophic osteopathy.) This is the combination of clubbing and thickening of periosteum (connective tissue lining of the bones) and synovium (lining of joints), and is often initially diagnosed as arthritis. It is commonly associated with lung cancer.
• Primary HOA
  • Primary hypertrophic osteo-arthropathy is HPOA without signs of pulmonary disease. This form has a hereditary component, although subtle cardiac abnormalties can occasionally be found. It is known in continental Europe as the Touraine-Solente-Golé syndrome. This condition has been linked to mutations in the gene on the fourth chromosome (4q33-q34)coding for the enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD); this leads to decreased breakdown of prostaglandin E2 and elevated levels of this substance.
• Secondary HOA
  • It is usually associated with lung cancer, pulmonary infections, cystic fibrosis, right-to-left cardiac shunts, and less often in Hodgkin's lymphoma and cirrhosis. Among patients with lung cancer, HOA is most frequently associated with adenocarcinoma and least frequently with small cell carcinoma Rarely, arterial vascular prosthesis infections may be associated with HOA. Clinical features suggestive of vascular infection-related HOA include clubbing or periosteal new bone formation in a single limb.

Gross Pathology

Clubbing

Causes

Causes by Organ System

Cardiovascular	Cyanotic congenital heart disease, Right-to-left shunting, Bacterial endocarditis, Tetralogy of fallot, Total anomalous pulmonary venous connection, Transposition of the great vessels, Tricuspid atresia, Truncus arteriosus, Arteriovenous malformations , Arterial vascular prosthesis infections, Atrial myxoma, Pulmonic stenosis
Chemical / poisoning	Cannabis, Lipoid pneumonia,
Dermatologic	No underlying causes
Drug Side Effect	Cannabis
Ear Nose Throat	Nasopharyngeal carcinoma
Endocrine	Thyroid cancer, Thyrotoxicosis
Environmental	Mesothelioma, Silicosis
Gastroenterologic	Ulcerative colitis, Crohn disease, Primary biliary cirrhosis, Cirrhosis of the liver, Leiomyoma of the esophagus, Achalasia, and Peptic ulcer of the esophagus, Celiac sprue, Hepatoma
Genetic	Cystic fibrosis
Hematologic	Myelofibrosis
Iatrogenic	Cannabis
Infectious Disease	Tuberculosis, Empyema
Musculoskeletal / Ortho	No underlying causes
Neurologic	Cerebrovascular insult
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Thyroid cancer, Thymus cancer, Hodgkin's disease, POEMS syndrome, Metastatic melanoma, Mesothelioma, Nasopharyngeal carcinoma, Myelofibrosis, Atrial myxoma,
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Lung cancer, Cystic fibrosis, Interstitial lung disease, Idiopathic pulmonary fibrosis, Sarcoidosis,Lipoid pneumonia, Empyema, Pleural mesothelioma, Pulmonary artery sarcoma, Cryptogenic fibrosing alveolitis, Pulmonary metastasis, Bronchiectasis
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Sarcoidosis

Causes in Alphabetical Order

• Achalasia
• Arteriovenous malformations
• Arterial vascular prosthesis infections
• Atrial myxoma
• Bronchial carcinoma
• Bronchiectasis
• Cannabis
• Celiac Sprue
• Cerebrovascular insult
• Chronic obstructive jaundice
• Cirrhosis
• Cyanotic congenital heart disease
  • Tetralogy of Fallot
  • Total anomalous venous connection
  • Transposition of the great vessels
  • Tricuspid atresia
  • Truncus arteriosus
• Cystic Fibrosis
• Endocarditis
• Empyema
• Hepatoma
• Hodgkin's lymphoma
• Interstitial lung disease
• Liver tumors
• Lung abscess
• Metastatic melanoma
• Mesothelioma
• Myelofibrosis
• Nasopharyngeal carcinoma
• Pachydermoperiostosis
• POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes): a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia in which clubbing may be seen. Other findings including peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes, sclerotic bone lesions, Castleman disease, thrombocytosis, papilledema, peripheral edema, pleural effusions, ascites, and white nails.
• Primary biliary cirrhosis
• Pulmonic stenosis
• Pulmonary artery sarcoma
• Pulmonary fibrosis
• Pulmonary metastases
• Right-to-left cardiac shunts
• Sarcoidosis of the lungs
• Silicosis
• Thyroid cancer
• Thyrotoxicosis
• Tuberculosis
• Ulcerative colitis
• Vascular anomalies

Epidemiology and Demographics

The exact frequency of clubbing in the population is not known. A 2008 study found clubbing in 1% of all patients admitted to a department of internal medicine. Of these, 40% turned out to have significant underlying disease of various causes, while 60% had no medical problems on further investigations and remained well over the subsequent year.

Diagnosis

Symptoms

Symptoms of the development of clubbing occur in five steps. They are as follows:

1. Fluctuation and softening of the nail bed (increased ballotability)
2. Loss of the normal <165° angle ("Lovibond angle") between the nailbed and the fold (cuticula)
3. Increased convexity of the nail fold
4. Thickening of the whole distal (end part of the) finger (resembling a drumstick)
5. Shiny aspect and striation of the nail and skin

Physical Examination

When clubbing is encountered in patients, doctors will seek to identify its cause. They usually accomplish this by obtaining a medical history— particular attention is paid to lung, heart, and gastrointestinal conditions —and conducting a clinical examination, which may disclose associated features relevant to a diagnosis.

Heart

Particular attention is paid to the heart in patients that present with digital clubbing.

Lungs

Particular attention is paid to the lungs in patients that present with digital clubbing.

Abdomen

Particular attention is paid to the abdomen because the doctor will be checking for gastrointestinal conditions that may be associated with digital clubbing.

Other Diagnostic Studies

Schamroth's test or Schamroth's window test (originally demonstrated by South African cardiologist Dr Leo Schamroth on himself) is a popular test for clubbing. When the distal phalanges (bones nearest the fingertips) of corresponding fingers of opposite hands are directly apposed (placed against each other back to back), a small diamond-shaped "window" is normally apparent between the nailbeds. If this window is obliterated, the test is positive and clubbing is present.

• 

  Clubbing of the fingernail. The red line shows the outline of a clubbed nail.

The following image shows a bone scan of a person with a special form of clubbing called HPOA.

Bone scan of a patient with Marie-Bamberger syndrome

See also

• Periosteal reaction for more on HPOA and primary HOA
• Clubbed thumb

References

Template:WikiDoc Sources