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Astrocytoma may be classified according to its [[histology]] into 4 grades: [[pilocytic astrocytoma]], [[diffuse astrocytoma]], [[anaplastic astrocytoma]] and [[glioblastoma multiforme]].
Astrocytoma may be classified according to its [[histology]] into 4 grades: [[pilocytic astrocytoma]], [[diffuse astrocytoma]], [[anaplastic astrocytoma]] and [[glioblastoma multiforme]].
==Classification==
==Classification==
Astrocytoma may be classified according to its histology into 4 grades:<ref name="pmid3179928">{{cite journal |vauthors=Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P |title=Grading of astrocytomas. A simple and reproducible method |journal=Cancer |volume=62 |issue=10 |pages=2152–65 |date=November 1988 |pmid=3179928 |doi= |url=}}</ref><ref name="pmid27157931">{{cite journal |vauthors=Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW |title=The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary |journal=Acta Neuropathol. |volume=131 |issue=6 |pages=803–20 |date=June 2016 |pmid=27157931 |doi=10.1007/s00401-016-1545-1 |url=}}</ref>
 
* Astrocytoma may be classified according to its histology into 4 grades:<ref name="pmid3179928">{{cite journal |vauthors=Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P |title=Grading of astrocytomas. A simple and reproducible method |journal=Cancer |volume=62 |issue=10 |pages=2152–65 |date=November 1988 |pmid=3179928 |doi= |url=}}</ref><ref name="pmid27157931">{{cite journal |vauthors=Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW |title=The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary |journal=Acta Neuropathol. |volume=131 |issue=6 |pages=803–20 |date=June 2016 |pmid=27157931 |doi=10.1007/s00401-016-1545-1 |url=}}</ref>


{{Family tree/start}}
{{Family tree/start}}
{{Family tree| | | | | | | | | | | | A01 | | | | | | | | | | | | |A01=Astrocytoma}}
{{Family tree| | | | | | | | | | | | A01 | | | | | | | | | | | | |A01=Astrocytoma}}
{{Family tree| | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|.| | | | | | | | | | | | | }}
{{Family tree| | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | | | | | | }}
{{Family tree| | | | | D01 | | | | | | | | | | | | D02 | | | | | | | | | | |D01=Low grade|D02=High grade}}
{{Family tree| | | | | D01 | | | | | | | | | | | D02 | | | | | | | | | | |D01=Low grade|D02=High grade}}
{{Family tree| | | |,|-|^|-|.| | | | | | | | | |,|-|^|-|.| | | | | | | | | | | | }}
{{Family tree| | | |,|-|^|-|.| | | | | | | | |,|-|^|-|.| | | | | | | | | | | | }}
{{Family tree| | | B01 | | B02 | | | | | | | | B03 | | B04 | | | | | | | | | | |B01=Pilocyic astrocytoma|B02=Diffuse astrocytoma|B03=Anaplastic astrocytoma|B04=Glioblastomas multiform}}
{{Family tree| | | B01 | | B02 | | | | | | | B03 | | B04 | | | | | | | | | | |B01=Pilocyic astrocytoma|B02=Diffuse astrocytoma|B03=Anaplastic astrocytoma|B04=Glioblastomas multiform}}
{{Family tree| |,|-|-|-|v|-|^|-|v|-|-|-|.| | | | |,|-|-|^|-|-|.| | | | }}
{{Family tree| |,|-|-|-|v|-|^|-|v|-|-|-|.| | | |,|-|-|^|-|-|.| | | | }}
{{Family tree| C01 | | C02 | | C03 | | C04 | | | C05 | | | | C06 | | |C01=[[Fibrillary astrocytoma]]|C02=[[Gemistocytic astrocytoma]]|C03=Protoplasmic astrocytoma|C04=Oligoastrocytoma|C05=Primary glioblastoma multiforme|C06=Secondary glioblastoma multiforme}}  
{{Family tree| C01 | | C02 | | C03 | | C04 | | | C05 | | | | C06 | | |C01=[[Fibrillary astrocytoma]]|C02=[[Gemistocytic astrocytoma]]|C03=[[Protoplasmic astrocytoma]]|C04=[[Oligoastrocytoma]]|C05=Primary glioblastoma multiforme|C06=Secondary glioblastoma multiforme}}  
{{Family tree/end}}
{{Family tree/end}}


<br />
* Low-grade astrocytoma may be classified based on tumor spread into four subtypes including:
{{familytree/start |summary=Low grade astrocytoma}}
{{familytree | | | | | | | | | | | | | A01| | | | | | | | | | | | | |A01=Low-grade astrocytoma}}
{{familytree | | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | |}}
{{familytree | | | | | | | B01 | | | | | | | | | | B02 | | | | | | | | |B01=[[Localized low-grade astrocytoma]]|B02=Low-grade infiltrative astrocytoma<br>Diffuse astrocytoma}}
{{familytree | | | | | | | F01 | | | | | | | | | | F02 | | | | | | | | |F01=WHO grade I / II|F02=WHO grade II}}
{{familytree | | | | | | | |!| | |,|-|-|-|v|-|-|-|v|^|-|.| | | | | | | |}}
{{familytree | | | | | | | |!| | C01 | | C02 | | C03 | | C04 | | | | | |C01=[[Fibrillary astrocytoma]]|C02=[[Gemistocytic astrocytoma]]|C03=[[Protoplasmic astrocytoma]]|C04=[[Oligoastrocytoma]]}}
{{familytree | |,|-|-|-|v|-|^|-|v|-|-|-|.| | | | | | | | | | | | | | |}}
{{familytree | D01 | | D02 | | D03 | | D04 | | | | | | | | | | | | | | |D01=[[Pilocytic astrocytoma]]|D02=Pilomyxoid astrocytoma|D03=[[Subependymal giant cell astrocytoma]]|D04=[[Pleomorphic xanthoastrocytoma]]}}
{{familytree | E01 | | E02 | | E03 | | E04 | | | | | | | | | | | | | |E01=WHO grade I|E02=WHO grade II|E03=WHO grade I|E04=WHO grade II}}
{{familytree/end}}


==References==
==References==

Latest revision as of 14:38, 25 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

Astrocytoma may be classified according to its histology into 4 grades: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma and glioblastoma multiforme.

Classification

  • Astrocytoma may be classified according to its histology into 4 grades:[1][2]
 
 
 
 
 
 
 
 
 
 
 
Astrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Low grade
 
 
 
 
 
 
 
 
 
 
High grade
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pilocyic astrocytoma
 
Diffuse astrocytoma
 
 
 
 
 
 
Anaplastic astrocytoma
 
Glioblastomas multiform
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Fibrillary astrocytoma
 
Gemistocytic astrocytoma
 
Protoplasmic astrocytoma
 
Oligoastrocytoma
 
 
Primary glioblastoma multiforme
 
 
 
Secondary glioblastoma multiforme
 
 



  • Low-grade astrocytoma may be classified based on tumor spread into four subtypes including:


 
 
 
 
 
 
 
 
 
 
 
 
Low-grade astrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Localized low-grade astrocytoma
 
 
 
 
 
 
 
 
 
Low-grade infiltrative astrocytoma
Diffuse astrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
WHO grade I / II
 
 
 
 
 
 
 
 
 
WHO grade II
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Fibrillary astrocytoma
 
Gemistocytic astrocytoma
 
Protoplasmic astrocytoma
 
Oligoastrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pilocytic astrocytoma
 
Pilomyxoid astrocytoma
 
Subependymal giant cell astrocytoma
 
Pleomorphic xanthoastrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
WHO grade I
 
WHO grade II
 
WHO grade I
 
WHO grade II
 
 
 
 
 
 
 
 
 
 
 
 
 

References

  1. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P (November 1988). "Grading of astrocytomas. A simple and reproducible method". Cancer. 62 (10): 2152–65. PMID 3179928.
  2. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (June 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary". Acta Neuropathol. 131 (6): 803–20. doi:10.1007/s00401-016-1545-1. PMID 27157931.