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{{Astrocytoma}}
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==Overview==
==Overview==
There are two broad classes of classification identified within astrocytomas, based on histology, as to whether the zones of infiltration of cancer cells are narrow or diffuse.
Astrocytoma may be classified according to its [[histology]] into 4 grades: [[pilocytic astrocytoma]], [[diffuse astrocytoma]], [[anaplastic astrocytoma]] and [[glioblastoma multiforme]].
==Classification==
==Classification==
Within the astrocytomas, there are two broad classes recognized in literature, those with:
* Narrow zones of infiltration (mostly invasive tumors; e.g., pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma), that often are clearly outlined on diagnostic images
* Diffuse zones of infiltration (e.g., low-grade astrocytoma, anaplastic astrocytoma, glioblastoma), that share various features, including the ability to arise at any location in the CNS, but with a preference for the cerebral hemispheres; they occur usually in adults; and an intrinsic tendency to progress to more advanced grades.<ref> http://emedicine.medscape.com/article/283453-overview </ref>


===Grading===
* Astrocytoma may be classified according to its histology into 4 grades:<ref name="pmid3179928">{{cite journal |vauthors=Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P |title=Grading of astrocytomas. A simple and reproducible method |journal=Cancer |volume=62 |issue=10 |pages=2152–65 |date=November 1988 |pmid=3179928 |doi= |url=}}</ref><ref name="pmid27157931">{{cite journal |vauthors=Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW |title=The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary |journal=Acta Neuropathol. |volume=131 |issue=6 |pages=803–20 |date=June 2016 |pmid=27157931 |doi=10.1007/s00401-016-1545-1 |url=}}</ref>
Astrocytomas have great variation in their presentation. The [[World Health Organization]] acknowledges the following grading system for astrocytomas:
 
* '''Grade 1''' — [[pilocytic astrocytoma]] - primarily pediatric tumor, with median age at diagnosis of 12
{{Family tree/start}}
* '''Grade 2''' — diffuse astrocytoma
{{Family tree| | | | | | | | | | | | A01 | | | | | | | | | | | | |A01=Astrocytoma}}
* '''Grade 3''' — anaplastic (malignant) astrocytoma
{{Family tree| | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | | | | | | }}
* '''Grade 4''' — [[glioblastoma multiforme]] (most common)
{{Family tree| | | | | D01 | | | | | | | | | | | D02 | | | | | | | | | | |D01=Low grade|D02=High grade}}
{{Family tree| | | |,|-|^|-|.| | | | | | | | |,|-|^|-|.| | | | | | | | | | | | }}
{{Family tree| | | B01 | | B02 | | | | | | | B03 | | B04 | | | | | | | | | | |B01=Pilocyic astrocytoma|B02=Diffuse astrocytoma|B03=Anaplastic astrocytoma|B04=Glioblastomas multiform}}
{{Family tree| |,|-|-|-|v|-|^|-|v|-|-|-|.| | | |,|-|-|^|-|-|.| | | | }}
{{Family tree| C01 | | C02 | | C03 | | C04 | | | C05 | | | | C06 | | |C01=[[Fibrillary astrocytoma]]|C02=[[Gemistocytic astrocytoma]]|C03=[[Protoplasmic astrocytoma]]|C04=[[Oligoastrocytoma]]|C05=Primary glioblastoma multiforme|C06=Secondary glioblastoma multiforme}}
{{Family tree/end}}
 
 


In addition to these four tumor grades, astrocytomas may combine with oligodendrocytes to produce [[oligoastrocytoma]]. Unique astrocytoma variants have also been known to exist.
<br />


==See Also==
* Low-grade astrocytoma may be classified based on tumor spread into four subtypes including:
{{main|pilocytic astrocytoma|glioblastoma multiforme}}




{{familytree/start |summary=Low grade astrocytoma}}
{{familytree | | | | | | | | | | | | | A01| | | | | | | | | | | | | |A01=Low-grade astrocytoma}}
{{familytree | | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | |}}
{{familytree | | | | | | | B01 | | | | | | | | | | B02 | | | | | | | | |B01=[[Localized low-grade astrocytoma]]|B02=Low-grade infiltrative astrocytoma<br>Diffuse astrocytoma}}
{{familytree | | | | | | | F01 | | | | | | | | | | F02 | | | | | | | | |F01=WHO grade I / II|F02=WHO grade II}}
{{familytree | | | | | | | |!| | |,|-|-|-|v|-|-|-|v|^|-|.| | | | | | | |}}
{{familytree | | | | | | | |!| | C01 | | C02 | | C03 | | C04 | | | | | |C01=[[Fibrillary astrocytoma]]|C02=[[Gemistocytic astrocytoma]]|C03=[[Protoplasmic astrocytoma]]|C04=[[Oligoastrocytoma]]}}
{{familytree | |,|-|-|-|v|-|^|-|v|-|-|-|.| | | | | | | | | | | | | | |}}
{{familytree | D01 | | D02 | | D03 | | D04 | | | | | | | | | | | | | | |D01=[[Pilocytic astrocytoma]]|D02=Pilomyxoid astrocytoma|D03=[[Subependymal giant cell astrocytoma]]|D04=[[Pleomorphic xanthoastrocytoma]]}}
{{familytree | E01 | | E02 | | E03 | | E04 | | | | | | | | | | | | | |E01=WHO grade I|E02=WHO grade II|E03=WHO grade I|E04=WHO grade II}}
{{familytree/end}}


==References==
==References==
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{{reflist|2}}
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[[Category:Pathology]]
[[Category:Pathology]]
[[Category:Neurosurgery]]
[[Category:Neurosurgery]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]

Latest revision as of 14:38, 25 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

Astrocytoma may be classified according to its histology into 4 grades: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma and glioblastoma multiforme.

Classification

  • Astrocytoma may be classified according to its histology into 4 grades:[1][2]
 
 
 
 
 
 
 
 
 
 
 
Astrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Low grade
 
 
 
 
 
 
 
 
 
 
High grade
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pilocyic astrocytoma
 
Diffuse astrocytoma
 
 
 
 
 
 
Anaplastic astrocytoma
 
Glioblastomas multiform
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Fibrillary astrocytoma
 
Gemistocytic astrocytoma
 
Protoplasmic astrocytoma
 
Oligoastrocytoma
 
 
Primary glioblastoma multiforme
 
 
 
Secondary glioblastoma multiforme
 
 



  • Low-grade astrocytoma may be classified based on tumor spread into four subtypes including:


 
 
 
 
 
 
 
 
 
 
 
 
Low-grade astrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Localized low-grade astrocytoma
 
 
 
 
 
 
 
 
 
Low-grade infiltrative astrocytoma
Diffuse astrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
WHO grade I / II
 
 
 
 
 
 
 
 
 
WHO grade II
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Fibrillary astrocytoma
 
Gemistocytic astrocytoma
 
Protoplasmic astrocytoma
 
Oligoastrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pilocytic astrocytoma
 
Pilomyxoid astrocytoma
 
Subependymal giant cell astrocytoma
 
Pleomorphic xanthoastrocytoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
WHO grade I
 
WHO grade II
 
WHO grade I
 
WHO grade II
 
 
 
 
 
 
 
 
 
 
 
 
 

References

  1. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P (November 1988). "Grading of astrocytomas. A simple and reproducible method". Cancer. 62 (10): 2152–65. PMID 3179928.
  2. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (June 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary". Acta Neuropathol. 131 (6): 803–20. doi:10.1007/s00401-016-1545-1. PMID 27157931.