Amenorrhea causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Kiran Singh, M.D. [2]

Overview

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Haemosiderosis, heart disease
Chemical/Poisoning Alcoholism, chronic alcohol poisoning, chronic lead poisoning, chronic mercury poisoning, chronic morphine poisoning
Dental No underlying causes
Dermatologic Systemic lupus erythematosus,
Drug Side Effect Antidepressants, antipsychotics, chemotherapy, combined oral contraceptive pill, cyclophosphamide, epirubicin, ethanol, fluoxymesterone, metoclopramide, nandrolone, spironolactone, stanozolol,
Ear Nose Throat No underlying causes
Endocrine Acromegaly, 5-alpha-reductase deficiency, Achard-Thiers syndrome, addison's disease, adrenal cortex tumours, adrenal gland disorders, adrenocortical hyperplasia, Ahumada-del castillo syndrome, androgen insensitivity syndrome, anorexia nervosa, anovulation, anterior pituitary failure, arrhenoblastoma, autoimmune adrenalitis, breastfeeding, C21-hydroxylase deficiency, Chiari-Frommel syndrome, congenital adrenal hyperplasia , conn syndrome, constitutional delay of puberty, corpus luteum cyst , cortisone reductase deficiency, cretinism, cushing's disease, cushing syndrome, diabetes mellitus , dystrophia adipose-genitalis, eating disorders, empty sella syndrome, exogenous androgen use, Female athlete syndrome, Forbes-Albright syndrome, Frohlich's syndrome, fsh receptor deficiency, galactorrhea , galactorrhoea-hyperprolactinaemia, gnrh deficiency, hyperprolactinaemia, hyperthyroidism, hypogonadism, hypogonadotropic hypogonadism, hypopituitarism, hypothyroidism, incomplete androgen insensitivity, Kallmann syndrome, Laron syndrome , masculinization disorders,Mayer-Rokitansky syndrome, medroxyprogesterone acetate,menopause, mullerian aplasia., mullerian dysgenesis, multiple endocrine neoplasia type 1 , myxoedema, obesity, ovarian failure, ovarian insufficiency due to fsh resistance , ovarian insufficiency, familial, panhypopituitarism , perimenopause , pituitary apoplexy, pituitary dwarfism, pituitary infarct, pituitary tumour, polycystic ovary syndrome,premature ovarian failure, prolactinoma, pseudoamenorrhea, pseudocyesis, rapid weight loss, Sheehan syndrome, Simmond's disease, Stein-Leventhal syndrome, testicular feminization syndrome, testosterone, thyrotoxicosis, underweight, vanishing testes syndrome, weight gain, Xy female,
Environmental Climate change
Gastroenterologic Anorexia nervosa,autoimmune hepatitis , Bearn-Kunkel syndrome, celiac disease ,cystic fibrosis,eating disorders,haemosiderosis, hepatocellular carcinoma, inflammatory bowel disease, liver cirrhosis,malabsorption syndrome, rapid weight loss, weight gain,
Genetic 18p minus syndrome, agenesis of lower vagina, androgen insensitivity syndrome, C21-hydroxylase deficiency, celiac disease,chromosome 15q duplication syndrome,Chromosome 17p, partial deletion , cortisone reductase deficiency,defect in sry gene, cystic fibrosis, Down's syndrome, Fgfr1 mutation, galactose-1-phosphate uridyltransferase deficiency, gonadal dysgenesis, Kal1 mutation, Kallmann syndrome, Laurence-Moon-Biedl syndrome, Mayer-Rokitansky syndrome, ovarian insufficiency,familial, Prader-Willi syndrome , prokr2 mutation, tetrasomy X, triple X syndrome, Turner syndrome,vanishing testes syndrome, Werner syndrome, Xy female
Hematologic Anaemia, haemosiderosis, Hodgkin's disease,leukemia
Iatrogenic No underlying causes
Infectious Disease Mumps, tuberculosis
Musculoskeletal/Orthopedic No underlying causes
Neurologic Brain tumor, craniopharyngioma, dystrophia adipose-genitalis, empty sella syndrome, frohlich's syndrome, glioma, hypothalamic tumor, meningioma, ovarioleukodystrophy, traumatic brain injury,
Nutritional/Metabolic Dietetic deficiency,galactose-1-phosphate uridyltransferase deficiency,low weight,malabsorption syndrome, malnutrition, obesity, proprotein convertase 1/3 deficiency, rapid weight loss, underweight, vitamin A embryopathy, weight gain
Obstetric/Gynecologic Anovulation, asherman syndrome, autoimmune hepatitis , autoimmune oophoritis, cervical closure, combined oral contraceptive pill,complications from d&c procedure, corpus luteum cyst , defect in sry gene, ectopic pregnancy, fsh receptor deficiency, germinoma, granulosa-cell tumor, hematocolpos, haematometra, hematosalpinx, hydatidiform mole, hypogonadism, hysterectomy, imperforate hymen, Mayer-Rokitansky syndrome, menopause, mullerian aplasia, mullerian dysgenesis, ovarian cancer, ovarian failure, ovarian insufficiency due to fsh resistance , ovarian insufficiency, familial , ovarioleukodystrophy, ovary damage, perimenopause , polycystic ovary syndrome, pregnancy, premature ovarian failure, pseudoamenorrhea, pseudocyesis, reproductive disorders, Sheehan syndrome, Stein-Leventhal syndrome, tubal ligation syndrome , uterine aplasia, vaginal agenesis, vaginal closure, vaginal septum , virilizing ovarian tumor , Xy female,
Oncologic Granulosa cell tumor, hepatocellular carcinoma, Hodgkin's disease, hypothalamic tumor,leukemia, meningioma, ovarian cancer, prolactinoma, virilizing ovarian tumor
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric Alcoholism, anorexia nervosa, anxiety, bulimia, depression, eating disorders, emotional turmoil, excessive exercise, female athlete syndrome, grief, insanity, ovarioleukodystrophy, primary affective disorder, stress
Pulmonary Cystic fibrosis,tuberculosis
Renal/Electrolyte Chronic renal failure, Denys-Drash syndrome, hypokalaemic distal renal tubular acidosis, nephritis, systemic lupus erythematosus
Rheumatology/Immunology/Allergy Autoimmune adrenalitis, autoimmune hepatitis , autoimmune oophoritis, celiac disease ,systemic lupus erythematosus
Sexual No underlying causes
Trauma No underlying causes
Urologic Frasier syndrome
Miscellaneous Cranial irradiation,chronic illness,radiotherapy

Causes in Alphabetical Order

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Causes of Amenorrhea Based on Classification

Primary Amenorrhea[1] [2]

Secondary Amenorrhea

References

  1. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
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