Granulosa cell tumour
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Granulosa cell tumour Classification and external resources | |
| ICD-10 | C56. |
|---|---|
| ICD-9 | 183 |
| ICD-O: | 8620 |
| eMedicine | med/928 |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Granulosa cell tumours (or granulosa-theca) are part of the sex cord-stromal tumour group of ovarian neoplasms.
The peak age at which they occur is 50-55 years, but they may occur at any age.
Clinical presentation
Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age.
- If the patient is postmenopausal, she usually presents with abnormal uterine bleeding.
- If the patient is of reproductive age, she would present with menometrorrhagia.
- If the patient has not undergone puberty, isosexual-pseudo-precocity may be seen.
Histology
The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with blood. Hemoperitoneum is an infrequent but classical presentation. A large variety of histological presentations exists, but they have two key features:
- Call-Exner bodies (granulosa cells arranged haphazardly around a space containing eosinophilic fluid); and
- Pale uniform nuclei, often with grooves
See also
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
