Adult T-cell leukemia classification: Difference between revisions

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==Overview==
==Overview==
Based on the duration of symptoms and clinical presentation, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or lymphoma variant.
Based on the duration of symptoms and clinical presentation, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or lymphoma variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693  }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370  }} </ref>
==Classification==
==Classification==
* Based on the duration of symptoms and clinical presentaion, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or lymphoma variant.
* Based on the duration of symptoms and clinical presentaion, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or lymphoma variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693  }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370  }} </ref>
* The table below lists the details of adult T-cell leukemia clinical classification:
* The table below lists the details of adult T-cell leukemia clinical classification:



Revision as of 16:05, 22 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Based on the duration of symptoms and clinical presentation, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or lymphoma variant.[1][2]

Classification

  • Based on the duration of symptoms and clinical presentaion, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or lymphoma variant.[1][2]
  • The table below lists the details of adult T-cell leukemia clinical classification:
Clinical Variant Description
Acute adult T-cell leukemia
  • Leukaemic clinical presentation
  • Organomegaly present
  • Markedly elevated lactate dehydrogenase (LDH) level
  • Hypercalcaemia
Chronic adult T-cell leukemia
  • Lymphocyte count greater than 4×109/L
  • Cutaneous, pulmonary, and hepatic involvement
  • Lymphadenopathy
  • Normal serum LDH level (or less that twice the normal upper limit)
  • Normal serum calcium level
Smouldering adult T-cell leukemia
  • Cutaneous and/or pulmonary infiltrates
  • No other organ involvement
  • Normal lymphocyte count (1–5% ATLL cells)
  • Normal serum LDH level
  • Normal serum calcium level
Adult T-cell lymphoma
  • Organomegaly present
  • Less than 1% leukaemic cells in the circulation
  • Elevated serum LDH level
  • Hypercalcaemia present

References

  1. 1.0 1.1 Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
  2. 2.0 2.1 Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.

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