Grainy head gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

"The defined GRHL1 DNA‐binding consensus sequence (AACCGGTT) was identical to that defined for GRHL3, and also matched the consensus sequence for Drosophila GRH DNA binding, which we had previously identified by alignment of multiple GRH‐responsive gene regulatory regions (Wilanowski et al, 2002; Ting et al, 2005). Of note, the first of the two cytosines and the second of the guanines were invariant in both GRHL1 and GRHL3 CASTing assays."^[1]

"The putative GRHL1‐binding motif (GACTGGTT) is perfectly conserved, together with 6 bp upstream and 12 bp downstream flanking sequences, in three of the Dsg1 promoters: mouse Dsg1α, mouse Dsg1γ, and human DSG1 [...]. In the mouse Dsg1β promoter, this motif is slightly different (AACTGGTT), although the flanking sequences are still conserved."^[1]

"The consensus DNA‐binding sequence identified for GRHL1 is identical to that defined for Drosophila GRH (Wilanowski et al, 2002). In addition, the identification of cadherin genes as direct transcriptional targets of GRHL1 extends the links between the grh and cadherin gene families from Drosophila to mammals. The cadherin family consists of more than 100 members (including the protocadherins) involved in many diverse cellular and developmental events (Nollet et al, 2000). Among the known targets of Drosophila, GRH are two cadherin superfamily members, stan/fmi and E‐cadherin/shotgun (Lee and Adler, 2004; Almeida and Bray, 2005). The links between the two gene families have recently been extended in another model organism. A study of genome‐wide predictions of genetic interactions in C. elegans has identified a number of cadherin family members as prime targets for significant functional interactions with Grh‐1, the worm homologue of grh (Zhong and Sternberg, 2006). These included cdh‐6, a homologue of Drosophila stan, and hmp‐2, a β‐catenin. We have recently identified the mammalian homologue of E‐cadherin as a target of another member of the Grh‐like family, Grhl2 (JMC and SMJ, unpublished)."^[1]

Human genes

References

↑ ^1.0 ^1.1 ^1.2 Tomasz Wilanowski, Jacinta Caddy, Stephen B Ting, Nikki R Hislop, Loretta Cerruti, Alana Auden, Lin‐Lin Zhao, Stephen Asquith, Sarah Ellis, Rodney Sinclair, John M Cunningham and Stephen M Jane (21 February 2008). "Perturbed desmosomal cadherin expression in grainy head‐like 1‐null mice". The EMBO Journal. 27: 886–897. doi:10.1038/emboj.2008.24. Retrieved 7 February 2020.

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Grainy head gene transcriptions

Contents

Human genes

See also

References

External links

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