Beta-thalassemia natural history, complications and prognosis: Difference between revisions

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The prognosis of beta-thalassemia can also be influenced by [[cardiovascular]] involvement.  
The prognosis of beta-thalassemia can also be influenced by [[cardiovascular]] involvement.  
* Parenchymal injury secondary to myocardial iron deposition and immune-inflammatory processes are known to be primary reasons for cardiovascular disorders in patients with thalassemia.  
* [[Parenchymal]] injury secondary to myocardial iron deposition and immune-inflammatory processes are known to be primary reasons for [[cardiovascular]] disorders in patients with thalassemia.  
* Early abnormalities in ventricular myocardium can occur in patients with beta-thalassemia, even in those receiving effective chelation therapies.  
* Early abnormalities in [[ventricular]] myocardium can occur in patients with [[beta-thalassemia]], even in those receiving effective [[chelation]] therapies.  
* Aortic elasticity indices are impaired in patients with beta-thalassemia major, and these parameters may be used to predict cardiovascular complications in asymptomatic patients<ref name="pmid26346439">{{cite journal |vauthors=Sahin C, Basaran O, Altun I, Akin F, Topal Y, Topal H, Biteker M, Azik MF |title=Assessment of Myocardial Performance Index and Aortic Elasticity in Patients With Beta-Thalassemia Major |journal=J Clin Med Res |volume=7 |issue=10 |pages=795–801 |date=October 2015 |pmid=26346439 |pmc=4554220 |doi=10.14740/jocmr2293w |url=}}</ref>.
* [[Aortic]] elasticity indices are impaired in patients with [[beta-thalassemia major]], and these parameters may be used to predict [[cardiovascular]] complications in asymptomatic patients<ref name="pmid26346439">{{cite journal |vauthors=Sahin C, Basaran O, Altun I, Akin F, Topal Y, Topal H, Biteker M, Azik MF |title=Assessment of Myocardial Performance Index and Aortic Elasticity in Patients With Beta-Thalassemia Major |journal=J Clin Med Res |volume=7 |issue=10 |pages=795–801 |date=October 2015 |pmid=26346439 |pmc=4554220 |doi=10.14740/jocmr2293w |url=}}</ref>.


==References==
==References==

Revision as of 08:10, 25 August 2023

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]

Overview

Without regular blood transfusions, affected individuals by major beta-thalassemia typically develop severe anemia and other complications such as pulmonary hypertension, right heart failure, iron overload, infections early in life, while beta-thalassemia intermedia patients would have a variable clinical course, complications, and prognosis. Beta-thalassemia minor subjects would not have significant symptoms, while in some cases might have an increased risk for iron deficiency anemia. Iron overload complications happen in transfusion-dependent thalassemia.

Natural history

Complications

Beta-thalassemia is associated with complications such as:

Prognosis

The prognosis of beta-thalassemia depends on the severity of the disease and the presence of complications.

The prognosis of beta-thalassemia can also be influenced by cardiovascular involvement.

References

  1. Tang CH, Furnback W, Wang B, Tang J, Tang D, Lu MY, Huang VW, Musallam KM (October 2021). "Relationship between transfusion burden, healthcare resource utilization, and complications in patients with beta-thalassemia in Taiwan: A real-world analysis". Transfusion. 61 (10): 2906–2917. doi:10.1111/trf.16636. PMC 9291481 Check |pmc= value (help). PMID 34505291 Check |pmid= value (help). Vancouver style error: initials (help)
  2. Bloomfield GS, Lagat DK, Akwanalo OC, Carter EJ, Lugogo N, Vedanthan R, Velazquez EJ, Kimaiyo S, Sherman CB (September 2012). "Waiting to inhale: An exploratory review of conditions that may predispose to pulmonary hypertension and right heart failure in persons exposed to household air pollution in low- and middle-income countries". Glob Heart. 7 (3): 249–259. doi:10.1016/j.gheart.2012.06.015. PMC 3653331. PMID 23687634.
  3. 3.0 3.1 Bender MA, Hulihan M, Dorley MC, Aguinaga M, Ojodu J, Yusuf C (December 2021). "Newborn Screening Practices for Beta-Thalassemia in the United States". Int J Neonatal Screen. 7 (4). doi:10.3390/ijns7040083. PMC 8703506 Check |pmc= value (help). PMID 34940053 Check |pmid= value (help). Vancouver style error: initials (help)
  4. Shazia Q, Mohammad ZH, Rahman T, Shekhar HU (2012). "Correlation of oxidative stress with serum trace element levels and antioxidant enzyme status in Beta thalassemia major patients: a review of the literature". Anemia. 2012: 270923. doi:10.1155/2012/270923. PMC 3357501. PMID 22645668.
  5. Manisha S, Sanjeev K, Seema N, Dilip C, Rashmi D (2015). "A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India". Indian J Hematol Blood Transfus. 31 (3): 367–73. doi:10.1007/s12288-014-0462-5. PMC 4465515. PMID 26085723.
  6. Galanello R, Origa R (May 2010). "Beta-thalassemia". Orphanet J Rare Dis. 5: 11. doi:10.1186/1750-1172-5-11. PMC 2893117. PMID 20492708.
  7. Sahin C, Basaran O, Altun I, Akin F, Topal Y, Topal H, Biteker M, Azik MF (October 2015). "Assessment of Myocardial Performance Index and Aortic Elasticity in Patients With Beta-Thalassemia Major". J Clin Med Res. 7 (10): 795–801. doi:10.14740/jocmr2293w. PMC 4554220. PMID 26346439.


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