Grainy head transcription factor gene transcriptions: Difference between revisions

Associate Editor(s)-in-Chief: Henry A. Hoff

"The defined GRHL1 DNA‐binding consensus sequence (AACCGGTT) was identical to that defined for GRHL3, and also matched the consensus sequence for Drosophila GRH DNA binding, which we had previously identified by alignment of multiple GRH‐responsive gene regulatory regions (Wilanowski et al, 2002; Ting et al, 2005). Of note, the first of the two cytosines and the second of the guanines were invariant in both GRHL1 and GRHL3 CASTing assays."^[1]

Human genes

Interactions

Consensus sequences

"The putative GRHL1‐binding motif (GACTGGTT) is perfectly conserved, together with 6 bp upstream and 12 bp downstream flanking sequences, in three of the Dsg1 promoters: mouse Dsg1α, mouse Dsg1γ, and human DSG1 [...]. In the mouse Dsg1β promoter, this motif is slightly different (AACTGGTT), although the flanking sequences are still conserved."^[1]

All "GRHL proteins bind to the consensus sequence 5′-AACCGGTT-3′ as a dimer [37,38,39]."^[2]

Samplings

Copying the GRHL1 DNA‐binding consensus sequence AACCGGTT and putting it in "⌘F" finds none located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence AACCGGTT (starting with SuccessablesGRH.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for AACCGGTT, 0.
negative strand, positive direction, looking for AACCGGTT, 0.
positive strand, negative direction, looking for AACCGGTT, 0.
positive strand, positive direction, looking for AACCGGTT, 0.
complement, negative strand, negative direction, looking for TTGGCCAA, 0.
complement, negative strand, positive direction, looking for TTGGCCAA, 0.
complement, positive strand, negative direction, looking for TTGGCCAA, 0.
complement, positive strand, positive direction, looking for TTGGCCAA, 0.
inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.
inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0.
inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
inverse negative strand, negative direction, looking for AAAAAAAA, 0.
inverse negative strand, positive direction, looking for AAAAAAAA, 0.
inverse positive strand, negative direction, looking for AAAAAAAA, 0.
inverse positive strand, positive direction, looking for AAAAAAAA, 0.

AAA core promoters

AAA proximal promoters

AAA distal promoters

References

↑ ^1.0 ^1.1 Tomasz Wilanowski, Jacinta Caddy, Stephen B Ting, Nikki R Hislop, Loretta Cerruti, Alana Auden, Lin‐Lin Zhao, Stephen Asquith, Sarah Ellis, Rodney Sinclair, John M Cunningham and Stephen M Jane (21 February 2008). "Perturbed desmosomal cadherin expression in grainy head‐like 1‐null mice". The EMBO Journal. 27: 886–897. doi:10.1038/emboj.2008.24. PMID 18288204. Retrieved 7 February 2020.
↑ Felix J. Boivin & Kai M. Schmidt-Ott (15 December 2018). "Functional roles of Grainyhead-like transcription factors in renal development and disease". Pediatric Nephrology. 35: 181–190. doi:10.1007/s00467-018-4171-4. Retrieved 5 January 2021.

External links

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@@ Line 43: / Line 43: @@
 Copying the GRHL1 DNA‐binding consensus sequence AACCGGTT and putting it in "⌘F" finds none located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.
-For the Basic programs testing consensus sequence AAAAAAAA (starting with SuccessablesAAA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
+For the Basic programs testing consensus sequence AACCGGTT (starting with SuccessablesGRH.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
-# negative strand, negative direction, looking for AAAAAAAA, 0.
+# negative strand, negative direction, looking for AACCGGTT, 0.
-# negative strand, positive direction, looking for AAAAAAAA, 0.
+# negative strand, positive direction, looking for AACCGGTT, 0.
-# positive strand, negative direction, looking for AAAAAAAA, 0.
+# positive strand, negative direction, looking for AACCGGTT, 0.
-# positive strand, positive direction, looking for AAAAAAAA, 0.
+# positive strand, positive direction, looking for AACCGGTT, 0.
-# complement, negative strand, negative direction, looking for TTTTTTTT, 0.
+# complement, negative strand, negative direction, looking for TTGGCCAA, 0.
-# complement, negative strand, positive direction, looking for TTTTTTTT, 0.
+# complement, negative strand, positive direction, looking for TTGGCCAA, 0.
-# complement, positive strand, negative direction, looking for TTTTTTTT, 0.
+# complement, positive strand, negative direction, looking for TTGGCCAA, 0.
-# complement, positive strand, positive direction, looking for TTTTTTTT, 0.
+# complement, positive strand, positive direction, looking for TTGGCCAA, 0.
 # inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
 # inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.