Delta catenin: Difference between revisions
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'''Delta-1-catenin''' and '''Delta-2-catenin''' are members of a subfamily of proteins with ten [[Armadillo-repeats]]. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.<ref>{{cite journal |vauthors=Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X |title=Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction |journal=Curr. Biol. |volume=14 |issue=18 |pages=1657–63 |date=September 2004 |pmid=15380068 |doi=10.1016/j.cub.2004.08.065 |url=http://linkinghub.elsevier.com/retrieve/pii/S0960982204006761}}</ref> Like [[beta-catenin]] and [[Plakoglobin|gamma-catenin]], delta-catenins seem to interact with [[Early-onset Alzheimer's disease#PSEN1 - Presenilin 1|presenilin]]s.<ref>{{cite journal |vauthors=Rubio ME, Curcio C, Chauvet N, Brusés JL |title=Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1 |journal=Mol. Cell. Neurosci. |volume=30 |issue=4 |pages=611–23 |date=December 2005 |pmid=16456928 | doi = 10.1016/j.mcn.2005.06.005 }}</ref> These catenin-presenilin interaction have implications for [[cadherin]] function and regulation of cell-to-cell adhesion.<ref>{{cite journal |vauthors=Teo JL, Ma H, Nguyen C, Lam C, Kahn M |title=Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=34 |pages=12171–6 |date=August 2005 |pmid=16093313 |pmc=1189325 |doi=10.1073/pnas.0504600102 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16093313}}</ref> | '''Delta-1-catenin''' and '''Delta-2-catenin''' are members of a subfamily of proteins with ten [[Armadillo-repeats]]. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.<ref>{{cite journal |vauthors=Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X |title=Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction |journal=Curr. Biol. |volume=14 |issue=18 |pages=1657–63 |date=September 2004 |pmid=15380068 |doi=10.1016/j.cub.2004.08.065 |url=http://linkinghub.elsevier.com/retrieve/pii/S0960982204006761}}</ref> Like [[beta-catenin]] and [[Plakoglobin|gamma-catenin]], delta-catenins seem to interact with [[Early-onset Alzheimer's disease#PSEN1 - Presenilin 1|presenilin]]s.<ref>{{cite journal |vauthors=Rubio ME, Curcio C, Chauvet N, Brusés JL |title=Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1 |journal=Mol. Cell. Neurosci. |volume=30 |issue=4 |pages=611–23 |date=December 2005 |pmid=16456928 | doi = 10.1016/j.mcn.2005.06.005 }}</ref> These catenin-presenilin interaction have implications for [[cadherin]] function and regulation of cell-to-cell adhesion.<ref>{{cite journal |vauthors=Teo JL, Ma H, Nguyen C, Lam C, Kahn M |title=Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=34 |pages=12171–6 |date=August 2005 |pmid=16093313 |pmc=1189325 |doi=10.1073/pnas.0504600102 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16093313}}</ref> | ||
While beta-catenin acts as a transcription | While beta-catenin acts as a transcription regulatory protein in the [[Wnt signaling pathway|Wnt/TCF]] pathway, delta-catenin 1 has been implicated as a regulator of the [[NF-κB]] transcription factor.<ref>{{cite journal |vauthors=Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E |title=p120-catenin mediates inflammatory responses in the skin |journal=Cell |volume=124 |issue=3 |pages=631–44 |date=February 2006 |pmid=16469707 |pmc=2443688 |doi=10.1016/j.cell.2005.11.043 |url=http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(06)00008-0}}</ref> | ||
[[Palmitoylation]] of delta-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.<ref>{{cite journal |vauthors=Brigidi GS, Sun Y, Beccano-Kelly D, Pitman K, Jobasser M, Borgland SL, Milnerwood AJ, Bamji SX |title=Palmitoylation of [delta]-catenin by DHHC5 mediates activity-induced synapse plasticity |journal=Nature Neuroscience |date=January 23, 2014 |doi=10.1038/nn.3657}}</ref> | [[Palmitoylation]] of delta-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.<ref>{{cite journal |vauthors=Brigidi GS, Sun Y, Beccano-Kelly D, Pitman K, Jobasser M, Borgland SL, Milnerwood AJ, Bamji SX |title=Palmitoylation of [delta]-catenin by DHHC5 mediates activity-induced synapse plasticity |journal=Nature Neuroscience |date=January 23, 2014 |doi=10.1038/nn.3657|pmc=5025286 }}</ref> | ||
==References== | ==References== | ||
| Line 48: | Line 48: | ||
==See also== | ==See also== | ||
*[[Catenin]] | *[[Catenin]] | ||
*[[CTNND1]] | |||
{{Cytoskeletal Proteins}} | {{Cytoskeletal Proteins}} | ||
Latest revision as of 10:18, 7 December 2018
| catenin (cadherin-associated protein), delta 1 | |
|---|---|
| Identifiers | |
| Symbol | CTNND1 |
| Alt. symbols | CTNND |
| Entrez | 1500 |
| HUGO | 2515 |
| OMIM | 601045 |
| RefSeq | NM_001331 |
| UniProt | O60716 |
| Other data | |
| Locus | Chr. 11 q12.1 |
| catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | |
|---|---|
| Identifiers | |
| Symbol | CTNND2 |
| Entrez | 1501 |
| HUGO | 2516 |
| OMIM | 604275 |
| RefSeq | NM_001332 |
| UniProt | Q9UQB3 |
| Other data | |
| Locus | Chr. 5 p15.2 |
Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]
While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin 1 has been implicated as a regulator of the NF-κB transcription factor.[4]
Palmitoylation of delta-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.[5]
References
- ↑ Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X (September 2004). "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction". Curr. Biol. 14 (18): 1657–63. doi:10.1016/j.cub.2004.08.065. PMID 15380068.
- ↑ Rubio ME, Curcio C, Chauvet N, Brusés JL (December 2005). "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1". Mol. Cell. Neurosci. 30 (4): 611–23. doi:10.1016/j.mcn.2005.06.005. PMID 16456928.
- ↑ Teo JL, Ma H, Nguyen C, Lam C, Kahn M (August 2005). "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation". Proc. Natl. Acad. Sci. U.S.A. 102 (34): 12171–6. doi:10.1073/pnas.0504600102. PMC 1189325. PMID 16093313.
- ↑ Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E (February 2006). "p120-catenin mediates inflammatory responses in the skin". Cell. 124 (3): 631–44. doi:10.1016/j.cell.2005.11.043. PMC 2443688. PMID 16469707.
- ↑ Brigidi GS, Sun Y, Beccano-Kelly D, Pitman K, Jobasser M, Borgland SL, Milnerwood AJ, Bamji SX (January 23, 2014). "Palmitoylation of [delta]-catenin by DHHC5 mediates activity-induced synapse plasticity". Nature Neuroscience. doi:10.1038/nn.3657. PMC 5025286.
See also
 | This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |