Dynactin

Jump to navigation Jump to search

WikiDoc Resources for Dynactin

Articles

Most recent articles on Dynactin

Most cited articles on Dynactin

Review articles on Dynactin

Articles on Dynactin in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Dynactin

Images of Dynactin

Photos of Dynactin

Podcasts & MP3s on Dynactin

Videos on Dynactin

Evidence Based Medicine

Cochrane Collaboration on Dynactin

Bandolier on Dynactin

TRIP on Dynactin

Clinical Trials

Ongoing Trials on Dynactin at Clinical Trials.gov

Trial results on Dynactin

Clinical Trials on Dynactin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Dynactin

NICE Guidance on Dynactin

NHS PRODIGY Guidance

FDA on Dynactin

CDC on Dynactin

Books

Books on Dynactin

News

Dynactin in the news

Be alerted to news on Dynactin

News trends on Dynactin

Commentary

Blogs on Dynactin

Definitions

Definitions of Dynactin

Patient Resources / Community

Patient resources on Dynactin

Discussion groups on Dynactin

Patient Handouts on Dynactin

Directions to Hospitals Treating Dynactin

Risk calculators and risk factors for Dynactin

Healthcare Provider Resources

Symptoms of Dynactin

Causes & Risk Factors for Dynactin

Diagnostic studies for Dynactin

Treatment of Dynactin

Continuing Medical Education (CME)

CME Programs on Dynactin

International

Dynactin en Espanol

Dynactin en Francais

Business

Dynactin in the Marketplace

Patents on Dynactin

Experimental / Informatics

List of terms related to Dynactin

Overview

Dynactin or Dynein activator complex is a multi-subunit protein found in eukaryotic cells that aids in bidirectional intracellular organelle transport by binding to dynein and Kinesin II and linking them to the organelles to be transported.[1][2]

Structure and mechanism of action

Dynactin consists of many subunits of which the p150Glued doublet (encoded by the DCTN1 gene) is the largest and has been found to be essential for function. [1] This structure of dynactin is highly conserved in vertebrates. There are three isoforms encoded by a single gene.[3]

Dynactin interacts with dynein directly by the binding of dynein intermediate chains with the p150 (glued homolog) doublet.[4]

Functions

Dynactin is often essential for dynein activity[1] and can be thought of as a "dynein receptor"[4] that modulates binding of dynein to cell organelles which are to be transported along microtubules.[5]

Dynactin is involved in various processes like chromosome alignment and spindle organization[5] in cell division,[6] maintaining nuclear position[7] in addition to transport of various organelles in the cytoplasm. Dynactin also links Kinesin II to organelles.

See also

References

  1. 1.0 1.1 1.2 Schroer Trina A (November 2004). "Annual Review of Cell and Developmental Biology". 20: 759–779. doi:10.1146/annurev.cellbio.20.012103.094623.
  2. Deacon Sean W, Serpinskaya Anna S, Vaughan Patricia S, Fanarraga Monica Lopez, Vernos Isabelle, Vaughan Kevin T, Gelfand Vladimir I. "Dynactin is required for bidirectional organelle transport". The Journal of Cell Biology. 160 (3): 297–301. doi:10.1083/jcb.200210066.
  3. Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. "Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein". The Journal of Cell Biology. 115: 1639–1650.
  4. 4.0 4.1 Vaughan KT, Vallee RB (1995). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". J Cell Biol. 131 (6 Pt 1): 1507–16. PMID 8522607. Unknown parameter |month= ignored (help)
  5. 5.0 5.1 Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB. "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis". J Cell Biol. 132 (4): 617–33. PMID 8647893. Unknown parameter |month= ignored (help)
  6. Karki S, Holzbaur EL (1999). "Cytoplasmic dynein and dynactin in cell division and intracellular transport". Curr Opin Cell Biol. 11 (1): 45–53. doi:10.1016/S0955-0674(99)80006-4. PMID 10047518. Unknown parameter |month= ignored (help)
  7. Whited JL, Cassell A, Brouillette M, Garrity PA (2004). "Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons". Development. 131 (19): 4677–86. doi:10.1242/dev.01366. PMID 15329347. Unknown parameter |month= ignored (help)

Further reading