Type I keratin
Type I keratins (or Type I cytokeratins) constitutes the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. Most of the type I cytokeratins consist of acidic, low molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues.
Type I cytokeratins are encoded on chromosome 17q and encompasses: CK9, CK10, CK11, CK12, CK13, CK14, CK15, CK16, CK17, CK18, CK19 and CK20. Their molecular weight ranges from 40 kDa (CK19) to 64 kDa (CK9).
Proteins of the cytoskeleton
|Microfilaments||Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein|
|Intermediate filaments||type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B)|
|Microtubules||Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin|
|Catenins||Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin|
|Nonhuman||Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)|
|Other||APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin|
Protein: fibrous proteins
|Collagen||Type-I (COL1A1) - Type-II (COL2A1) - Type-III - Type-IV - Type-V - Type XI (COL11A2) - Type-XVII - Type-XVIII|
|Keratin/Cytokeratin||type I (10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), type II (1, 2A, 3, 4, 5, 6A, 7, 8, 9), Hair (Type I, Type II), Beta|
|other||Elastin - Cytoskeletal|
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