Fever of unknown origin causes: Difference between revisions

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=== Causes by Organ System===
=== Causes by Organ System===


{|style="width:80%; height:100px" border="1"
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Endocarditis]], [[Deep vein thrombosis]], [[Thrombophlebitis]]
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Endocarditis]], [[Deep vein thrombosis]], [[Thrombophlebitis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
| '''Chemical / poisoning'''
|bgcolor="Beige"| [[Bismuth]]
|bgcolor="Beige"| [[Bismuth]]
|-
|-


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===Causes by Alphabetical Order===  
===Causes by Alphabetical Order===  
{{MultiCol}}
{{Columns-list|3|
*[[Actinomycosis]]
*[[Actinomycosis]]
 
*[[Allergic bronchopulmonary aspergillosis]]
*[[Allopurinol]]
*[[Allopurinol]]
 
*[[Aminoglutethimide]]
*[[Amphotericin B]]
*[[Angioimmunoblastic lymphadenopathy with dysproteinaemia]]
*[[Angioimmunoblastic lymphadenopathy with dysproteinaemia]]
*[[Allergic bronchopulmonary aspergillosis]]
*[[Amphotericin B]]
*[[Aminoglutethimide]]
*[[Atrial myxoma]]
*[[Atrial myxoma]]
*[[Atypical pneumonia]]
*[[Atypical pneumonia]]
*[[Barbiturates]]
*[[Barbiturates]]
 
*[[Bismuth]]
*[[Blastomycosis]]
*[[Blastomycosis]]
*[[Bismuth]]
*[[Borrelia burgdorferi]]
*[[Borrelia burgdorferi]]
*[[Boutonneuse fever]]
*[[Boutonneuse fever]]
*[[Brucellosis]]
*[[Brucellosis]]
*[[Candida albicans]]
*[[Candida albicans]]
*Catheter infections
*Catheter infections
*[[Chlorpromazine]]
*[[Chlorpromazine]]
 
*[[Cholangitis]]
*[[Choledochal cyst]]
*[[Choledochal cyst]]
*[[Cholangitis]]
*[[Cirrhosis of liver]]
*[[Cirrhosis of liver]]
*[[Coccidioidomycosis]]
*[[Coccidioidomycosis]]
*[[Crohn's disease]]
*[[Crohn's disease]]
*[[Cryptococcus neoformans]]
*[[Cryptococcus neoformans]]
*[[Cyclical neutropenia]]
*[[Cyclical neutropenia]]
*[[Deep vein thrombosis]]
*[[Deep vein thrombosis]]
*[[Discitis]]
*[[Discitis]]
*[[Disseminated Intravascular Coagulation]]
*[[Disseminated Intravascular Coagulation]]
*[[Docetaxel]]
*[[Docetaxel]]
*[[Ehrlichiosis]]
*[[Ehrlichiosis]]
 
*[[Endocarditis]]
*[[Entamoeba histolytica]]
*[[Epstein-Barr virus]]
*[[Epstein-Barr virus]]
*[[Entamoeba histolytica]]
*[[Endocarditis]]
*[[Ethotoin]]
*[[Ethotoin]]
*[[Fabry's disease]]
*[[Fabry's disease]]
*[[Fasciola hepatica]]
*[[Fasciola hepatica]]
*[[GMCSF]]
*[[GMCSF]]
 
*[[Gonorrhoea]]
*[[Hepatitis B]]
*[[Hepatitis B]]
*[[Hereditary sensory and autonomic neuropathy]] type 3
*[[Hereditary sensory and autonomic neuropathy]] type 3
 
*[[Histoplasmosis]]
*[[HIV-1 disease]]
*[[HIV-1 disease]]
*[[Histoplasmosis]]
*[[Hodgkin's lymphoma]]
*[[Hodgkin's lymphoma]]
*[[Hyperimmunoglobulinemia D and periodic fever syndrome]]
*[[Hyperimmunoglobulinemia D and periodic fever syndrome]]
*Invasive [[aspergillosis]]<ref name="pmid23331746">{{cite journal |author=Méndez-Tovar LJ, Manzano-Gayosso P, Cumplido-Uribe C, Hernández-Hernández F, Ramos-Hernández J, López-Martínez R |title=[Invasive mycosis, immunocompromise and fever of unknown origin] |language=Spanish; Castilian |journal=Rev Med Inst Mex Seguro Soc |volume=50 |issue=6 |pages=609–14 |year=2012 |pmid=23331746 |doi= |url=}}</ref>
*Invasive [[aspergillosis]]<ref name="pmid23331746">{{cite journal |author=Méndez-Tovar LJ, Manzano-Gayosso P, Cumplido-Uribe C, Hernández-Hernández F, Ramos-Hernández J, López-Martínez R |title=[Invasive mycosis, immunocompromise and fever of unknown origin] |language=Spanish; Castilian |journal=Rev Med Inst Mex Seguro Soc |volume=50 |issue=6 |pages=609–14 |year=2012 |pmid=23331746 |doi= |url=}}</ref>
*[[Juvenile chronic arthritis]]
*[[Juvenile chronic arthritis]]
*[[Levomepromazine]]
*[[Lepromatous leprosy]]
*[[Lepromatous leprosy]]
 
*[[Leptospira]] hebdomadis
*[[Leptospirosis]]
*[[Leptospirosis]]
 
*[[Levomepromazine]]
*[[Leptospira]] hebdomadis
 
*[[Listeria monocytogenes]]
*[[Listeria monocytogenes]]
*[[Liver abscess]]
*[[Liver abscess]]
*[[Lung abscess]]
*[[Lung abscess]]
*[[Lymphoma]]<ref name="pmid22989822">{{cite journal |author=Zhang J, Chen B, Xu X, ''et al.'' |title=Clinical features of 66 lymphoma patients presenting with a fever of unknown origin |journal=Intern. Med. |volume=51 |issue=18 |pages=2529–36 |year=2012 |pmid=22989822 |doi= |url=}}</ref>
*[[Lymphoma]]<ref name="pmid22989822">{{cite journal |author=Zhang J, Chen B, Xu X, ''et al.'' |title=Clinical features of 66 lymphoma patients presenting with a fever of unknown origin |journal=Intern. Med. |volume=51 |issue=18 |pages=2529–36 |year=2012 |pmid=22989822 |doi= |url=}}</ref>
*[[Malaria]]
*[[Malaria]]
*[[Methyldopa]]
*[[Methyldopa]]
*[[Mycobacterium avium-intracellulare]]
*[[Mycobacterium avium-intracellulare]]
*[[Mycobacterium kansasii]]
*[[Mycobacterium kansasii]]
{{ColBreak}}
*[[Mycobacterium tuberculosis]]
*[[Mycobacterium tuberculosis]]
 
*[[Neisseria meningiditis]]
*[[Newcastle disease]]
*[[Newcastle disease]]
*[[Gonorrhoea]]
*[[Neisseria meningiditis]]
*[[Osteomyelitis]]
*[[Osteomyelitis]]
*[[Pancreatic cancer]]
*[[Pancreatic cancer]]
*[[Paraneoplastic syndrome]]
*[[Paraneoplastic syndrome]]
 
*[[Penicillin]]
*[[Perazine]]
*Periodic fever aphthous [[pharyngitis]] and cervical adenopathy
*Periodic fever aphthous [[pharyngitis]] and cervical adenopathy
*[[Perazine]]
*[[Penicillin]]
*Phenophthalein
*Phenophthalein
 
*[[Phenytoin]]
*[[Pipothiazine]]
*[[Pipothiazine]]
*[[Phenytoin]]
*[[Polyarteritis nodosa]]
*[[Polyarteritis nodosa]]
*[[Polymyalgia rheumatica]]
*[[Polymyalgia rheumatica]]
*[[Polymyositis]]
*[[Polymyositis]]
*[[Promazine]]
*[[Promazine]]
*[[Psittacosis]]
*[[Psittacosis]]
*[[Pulmonary embolism]]
*[[Pulmonary embolism]]
*[[Pyelonephritis]]
*[[Pyelonephritis]]
*[[Pyelonephritis classification|Xanthogranulomatous pyelonephritis]]
*[[Q fever]]<ref name="Granulomatous Hepatitis with Q fever">{{cite journal |author=Aguilar-Olivos N, Del Carmen Manzano-Robleda M, Gutiérrez-Grobe Y, Chablé-Montero F, Albores-Saavedra J, López-Méndez E |title=Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin |journal=Ann Hepatol |volume=12 |issue=1 |pages=138–41 |year=2013 |month=January |pmid=23293205 |doi= |url=}}</ref>
*[[Q fever]]<ref name="Granulomatous Hepatitis with Q fever">{{cite journal |author=Aguilar-Olivos N, Del Carmen Manzano-Robleda M, Gutiérrez-Grobe Y, Chablé-Montero F, Albores-Saavedra J, López-Méndez E |title=Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin |journal=Ann Hepatol |volume=12 |issue=1 |pages=138–41 |year=2013 |month=January |pmid=23293205 |doi= |url=}}</ref>
*[[Quinidine]]
*[[Quinidine]]
*[[Recurrent hereditary polyserositis]]
*[[Recurrent hereditary polyserositis]]
 
*[[Relapsing fever]]
*[[Renal adenocarcinoma]]<ref name="pmid22658892">{{cite journal |author=Chandrankunnel J, Cunha BA, Petelin A, Katz D |title=Fever of unknown origin (FUO) and a renal mass: renal cell carcinoma, renal tuberculosis, renal malakoplakia, or xanthogranulomatous pyelonephritis? |journal=Heart Lung |volume=41 |issue=6 |pages=606–9 |year=2012 |pmid=22658892 |doi=10.1016/j.hrtlng.2012.03.008 |url=}}</ref>
*[[Renal adenocarcinoma]]<ref name="pmid22658892">{{cite journal |author=Chandrankunnel J, Cunha BA, Petelin A, Katz D |title=Fever of unknown origin (FUO) and a renal mass: renal cell carcinoma, renal tuberculosis, renal malakoplakia, or xanthogranulomatous pyelonephritis? |journal=Heart Lung |volume=41 |issue=6 |pages=606–9 |year=2012 |pmid=22658892 |doi=10.1016/j.hrtlng.2012.03.008 |url=}}</ref>
*[[Relapsing fever]]
*[[Retroperitoneal fibrosis]]
*[[Retroperitoneal fibrosis]]
*[[Rheumatoid disease]]
*[[Rheumatoid disease]]
 
*[[Rickettsia]] akari
*[[Rifampicin]]
*[[Rifampicin]]
*[[Rickettsia]] akari
*[[Salmonella typhi]]
*[[Salmonella typhi]]
*[[Sarcoidosis]]
*[[Sarcoidosis]]
*[[Schnitzler syndrome]]
*[[Schnitzler syndrome]]
*[[Scrub typhus]]
*[[Scrub typhus]]
*[[Sinusitis]]
*[[Sinusitis]]
*[[Sleeping sickness]]
*[[Sleeping sickness]]
*[[Still's Disease]]
*[[Still's Disease]]
*[[Streptococcus suis]]
*[[Streptococcus suis]]
 
*Subdiaphragmatic [[abscess]]
*Surgery complication
*Surgery complication
*Subdiaphragmatic [[abscess]]
*[[Systemic lupus erythematosus]]<ref name="pmid22980227">{{cite journal |author=Petelin A, Johnson DH, Cunha BA |title=Fever of unknown origin (FUO) due to systemic lupus erythematosus (SLE) presenting as pericarditis |journal=Heart Lung |volume= |issue= |pages= |year=2012 |month=September |pmid=22980227 |doi=10.1016/j.hrtlng.2012.07.002 |url=}}</ref>
*[[Systemic lupus erythematosus]]<ref name="pmid22980227">{{cite journal |author=Petelin A, Johnson DH, Cunha BA |title=Fever of unknown origin (FUO) due to systemic lupus erythematosus (SLE) presenting as pericarditis |journal=Heart Lung |volume= |issue= |pages= |year=2012 |month=September |pmid=22980227 |doi=10.1016/j.hrtlng.2012.07.002 |url=}}</ref>
 
*[[Temporal arteritis]]
*[[Thrombophlebitis]]
*[[Toxoplasma]]
*[[Treponema pallidum]]
*[[Treponema pallidum]]
*[[Tularaemia]]
*[[Tularaemia]]
*[[Ulcerative colitis]]
*[[Ulcerative colitis]]
*[[UTI]]
*[[UTI]]
*[[Temporal arteritis]]
*[[Thrombophlebitis]]
*[[Toxoplasma]]
*[[Visceral leishmaniasis]]
*[[Visceral leishmaniasis]]
*[[Vitamin B12 deficiency]]
*[[Vitamin B12 deficiency]]
*[[Wegener's granulomatosis]]
*[[Wegener's granulomatosis]]
*[[Whipple's disease]]
*[[Whipple's disease]]
 
*[[Pyelonephritis classification|Xanthogranulomatous pyelonephritis]]
*[[Yersinia enterocolitica]]
*[[Yersinia enterocolitica]]
*[[Yersinia pseudotuberculosis]]
*[[Yersinia pseudotuberculosis]]
{{EndMultiCol}}
}}


==References==
==References==

Revision as of 17:34, 18 March 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Naresh Mullaguri, M.B.B.S. [2]

Causes

Common Causes

  • Extrapulmonary tuberculosis[1] - most frequent cause of fever of unknown origin.
  • Drug fever - adverse reactions of medications should always be considered as an important cause before starting actual evaluation for FUO.
  • Histoplasmosis
  • Coccidioidomycosis
  • Blastomycosis - any systemic granulomatous disease can be a cause of FUO.
  • Sarcoidosis - one of the important differential diagnosis for FUO in African-american population.
  • Lymphoma - most common cause of FUO in adults.
  • Pulmonary embolism
  • Deep venous thrombosis
  • Endocarditis - although it is a rare cause, it is always important to think over it as one of the differential diagnosis.
  • Factitious fever[2]- most of the times it is an underestimated cause of FUO but it is often important to consider it in people who worked in the medical field and majority of them are females.

Causes by Organ System

Cardiovascular Endocarditis, Deep vein thrombosis, Thrombophlebitis
Chemical / poisoning Bismuth
Dermatologic No underlying causes
Drug Side Effect Allopurinol, Amphotericin B, Aminoglutethimide, Barbiturates, Bismuth, Chlorpromazine, Docetaxel, Ethotoin, GMCSF, Levomepromazine, Methyldopa, Perazine, Phenophthalein, Pipothiazine, Promazine, Penicillin, Phenytoin, Quinidine, Rifampicin
Ear Nose Throat Periodic fever aphthous pharyngitis and cervical adenopathy, Sinusitis
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Cirrhosis of liver, Crohn's disease, Ulcerative Colitis, Whipple's disease, Choledochal cyst, Cholangitis
Genetic No underlying causes
Hematologic Angioimmunoblastic lymphadenopathy with dysproteinaemia, Hyperimmunoglobulinemia D and periodic fever syndrome
Iatrogenic No underlying causes
Infectious Disease Lung abscess, Subdiaphragmatic abscess, Liver abscess, Pyelonephritis, Salmonella typhi, Osteomyelitis, Gonorrhoea, Leptospirosis, Q fever, Endocarditis, Tularaemia, Scrub typhus, Relapsing fever, Rickettsia akari, Boutonneuse fever, Mycobacterium tuberculosis, Yersinia enterocolitica, Periodic fever aphthous pharyngitis and cervical adenopathy, Ehrlichiosis, Atypical pneumonia, Cyclical neutropenia, Xanthogranulomatous pyelonephritis, Streptococcus suis, Catheter infections, Lepromatous leprosy, Treponema pallidum, Neisseria meningiditis, UTI, Borrelia burgdorferi, Mycobacterium kansasii, Mycobacterium avium-intracellulare, Sinusitis, Actinomycosis, Yersinia pseudotuberculosis, Leptospira hebdomadis, Listeria monocytogenes, Brucellosis, Blastomycosis, Candida albicans, Allergic bronchopulmonary aspergillosis, Invasive aspergillosis, Cryptococcus neoformans, Psittacosis, Coccidioidomycosis, Histoplasmosis, Malaria, Toxoplasma, Sleeping sickness, Entamoeba histolytica, Visceral leishmaniasis, Fasciola hepatica, Epstein-Barr virus, Hepatitis B, HIV-1 disease, Newcastle disease
Musculoskeletal / Ortho Osteomyelitis, Discitis, Polymyalgia rheumatica
Neurologic Hereditary sensory and autonomic neuropathy type 3, Vitamin B12 deficiency
Nutritional / Metabolic Vitamin B12 deficiency
Obstetric/Gynecologic No underlying causes
Oncologic Renal adenocarcinoma, Hodgkin's lymphoma, Pancreatic cancer, Angioimmunoblastic lymphadenopathy with dysproteinaemia, Paraneoplastic syndrome, Atrial myxoma
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric Factitious fever
Pulmonary Lung abscess, Allergic bronchopulmonary aspergillosis, Invasive aspergillosis
Renal / Electrolyte Acute pyelonephritis, Xanthogranulomatous pyelonephritis
Rheum / Immune / Allergy Polyarteritis nodosa, Systemic lupus erythematosus, Polymyalgia rheumatica, Sarcoidosis, Polymyositis, Temporal arteritis, Juvenile chronic arthritis, Hyperimmunoglobulinemia D and periodic fever syndrome, Wegener's granulomatosis, Recurrent hereditary polyserositis, Disseminated Intravascular Coagulation, Still's Disease, Rheumatoid disease, Whipple's disease, Retroperitoneal fibrosis, Crohn's disease, Ulcerative colitis, Schnitzler syndrome
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Surgery complication, Fabry's disease

Causes by Alphabetical Order

The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3

References

  1. Harrison's Principles of Internal Medicine 16th Edition, The McGraw-Hill Companies, ISBN 0-07-140235-7
  2. Mandell's Principles and Practices of Infection Diseases 6th Edition (2004) by Gerald L. Mandell MD, MACP, John E. Bennett MD, Raphael Dolin MD, ISBN 0-443-06643-4 · Hardback · 4016 Pages Churchill Livingstone
  3. Méndez-Tovar LJ, Manzano-Gayosso P, Cumplido-Uribe C, Hernández-Hernández F, Ramos-Hernández J, López-Martínez R (2012). "[Invasive mycosis, immunocompromise and fever of unknown origin]". Rev Med Inst Mex Seguro Soc (in Spanish; Castilian). 50 (6): 609–14. PMID 23331746.
  4. Zhang J, Chen B, Xu X; et al. (2012). "Clinical features of 66 lymphoma patients presenting with a fever of unknown origin". Intern. Med. 51 (18): 2529–36. PMID 22989822.
  5. Aguilar-Olivos N, Del Carmen Manzano-Robleda M, Gutiérrez-Grobe Y, Chablé-Montero F, Albores-Saavedra J, López-Méndez E (2013). "Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin". Ann Hepatol. 12 (1): 138–41. PMID 23293205. Unknown parameter |month= ignored (help)
  6. Chandrankunnel J, Cunha BA, Petelin A, Katz D (2012). "Fever of unknown origin (FUO) and a renal mass: renal cell carcinoma, renal tuberculosis, renal malakoplakia, or xanthogranulomatous pyelonephritis?". Heart Lung. 41 (6): 606–9. doi:10.1016/j.hrtlng.2012.03.008. PMID 22658892.
  7. Petelin A, Johnson DH, Cunha BA (2012). "Fever of unknown origin (FUO) due to systemic lupus erythematosus (SLE) presenting as pericarditis". Heart Lung. doi:10.1016/j.hrtlng.2012.07.002. PMID 22980227. Unknown parameter |month= ignored (help)