Primary biliary cirrhosis history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
The majority of patients with early primary biliary cirrhosis are asymptomatic. | The majority of patients with early primary biliary cirrhosis are asymptomatic.The hallmark of primary biliary cirrhosis is [[pruritis]], worse at night. The most common symptoms of primary biliary cirrhosis include [[fatigue]], [[pruritis]], and [[jaundice]]. | ||
The hallmark of primary biliary cirrhosis is pruritis, worse at night | |||
==History and Symptoms== | ==History and Symptoms== | ||
*The majority of patients with early primary biliary cirrhosis are asymptomatic.<ref name="pmid12360466">{{cite journal| author=Prince M, Chetwynd A, Newman W, Metcalf JV, James OF| title=Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years. | journal=Gastroenterology | year= 2002 | volume= 123 | issue= 4 | pages= 1044-51 | pmid=12360466 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12360466 }} </ref> | *The majority of patients with early primary biliary cirrhosis are asymptomatic.<ref name="pmid12360466">{{cite journal| author=Prince M, Chetwynd A, Newman W, Metcalf JV, James OF| title=Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years. | journal=Gastroenterology | year= 2002 | volume= 123 | issue= 4 | pages= 1044-51 | pmid=12360466 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12360466 }} </ref> | ||
*The hallmark of primary biliary cirrhosis is pruritis, worse at night. The most common symptoms of primary biliary cirrhosis include fatigue, | *The hallmark of primary biliary cirrhosis is [[pruritis]], worse at night. The most common symptoms of primary biliary cirrhosis include [[fatigue]], [[pruritis]], and [[jaundice]]. | ||
===History=== | ===History=== | ||
Patients with primary biliary cirrhosis may have a positive history of:<ref name="pmid2197212">{{cite journal| author=Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A et al.| title=The demography of primary biliary cirrhosis in Ontario, Canada. | journal=Hepatology | year= 1990 | volume= 12 | issue= 1 | pages= 98-105 | pmid=2197212 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2197212 }} </ref> | Patients with primary biliary cirrhosis may have a positive history of:<ref name="pmid2197212">{{cite journal| author=Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A et al.| title=The demography of primary biliary cirrhosis in Ontario, Canada. | journal=Hepatology | year= 1990 | volume= 12 | issue= 1 | pages= 98-105 | pmid=2197212 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2197212 }} </ref> | ||
*Pruritis, worse at night | *[[Pruritis]], worse at night | ||
*Fatigue | *[[Fatigue]] | ||
*Daytime somnolence<ref name="pmid16800007">{{cite journal| author=Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D| title=Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. | journal=Hepatology | year= 2006 | volume= 44 | issue= 1 | pages= 91-8 | pmid=16800007 | doi=10.1002/hep.21230 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16800007 }} </ref> | *Daytime [[somnolence]]<ref name="pmid16800007">{{cite journal| author=Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D| title=Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. | journal=Hepatology | year= 2006 | volume= 44 | issue= 1 | pages= 91-8 | pmid=16800007 | doi=10.1002/hep.21230 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16800007 }} </ref> | ||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of primary biliary cirrhosis include:<ref name="pmid2197212">{{cite journal| author=Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A et al.| title=The demography of primary biliary cirrhosis in Ontario, Canada. | journal=Hepatology | year= 1990 | volume= 12 | issue= 1 | pages= 98-105 | pmid=2197212 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2197212 }} </ref> | Common symptoms of primary biliary cirrhosis include:<ref name="pmid2197212">{{cite journal| author=Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A et al.| title=The demography of primary biliary cirrhosis in Ontario, Canada. | journal=Hepatology | year= 1990 | volume= 12 | issue= 1 | pages= 98-105 | pmid=2197212 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2197212 }} </ref> | ||
*Fatigue | *[[Fatigue]] | ||
*Pruritis | *[[Pruritis]] | ||
*Jaundice | *[[Jaundice]] | ||
*Right upper quadrant pain (10%)<ref name="pmid7942679">{{cite journal| author=Laurin JM, DeSotel CK, Jorgensen RA, Dickson ER, Lindor KD| title=The natural history of abdominal pain associated with primary biliary cirrhosis. | journal=Am J Gastroenterol | year= 1994 | volume= 89 | issue= 10 | pages= 1840-3 | pmid=7942679 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7942679 }} </ref> | *[[Right upper quadrant pain]] (10%)<ref name="pmid7942679">{{cite journal| author=Laurin JM, DeSotel CK, Jorgensen RA, Dickson ER, Lindor KD| title=The natural history of abdominal pain associated with primary biliary cirrhosis. | journal=Am J Gastroenterol | year= 1994 | volume= 89 | issue= 10 | pages= 1840-3 | pmid=7942679 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7942679 }} </ref> | ||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of primary biliary cirrhosis include:<ref name="pmid18215315">{{cite journal| author=Kumagi T, Heathcote EJ| title=Primary biliary cirrhosis. | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue= | pages= 1 | pmid=18215315 | doi=10.1186/1750-1172-3-1 | pmc=2266722 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18215315 }} </ref> | Less common symptoms of primary biliary cirrhosis include:<ref name="pmid18215315">{{cite journal| author=Kumagi T, Heathcote EJ| title=Primary biliary cirrhosis. | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue= | pages= 1 | pmid=18215315 | doi=10.1186/1750-1172-3-1 | pmc=2266722 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18215315 }} </ref> | ||
*Variceal bleeding | *[[Variceal bleeding]] | ||
*Abdominal distension | *[[Abdominal distension]] | ||
*Hepatic encephalopathy | *[[Hepatic encephalopathy]] | ||
==References== | ==References== |
Revision as of 16:29, 5 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
The majority of patients with early primary biliary cirrhosis are asymptomatic.The hallmark of primary biliary cirrhosis is pruritis, worse at night. The most common symptoms of primary biliary cirrhosis include fatigue, pruritis, and jaundice.
History and Symptoms
- The majority of patients with early primary biliary cirrhosis are asymptomatic.[1]
- The hallmark of primary biliary cirrhosis is pruritis, worse at night. The most common symptoms of primary biliary cirrhosis include fatigue, pruritis, and jaundice.
History
Patients with primary biliary cirrhosis may have a positive history of:[2]
- Pruritis, worse at night
- Fatigue
- Daytime somnolence[3]
Common Symptoms
Common symptoms of primary biliary cirrhosis include:[2]
Less Common Symptoms
Less common symptoms of primary biliary cirrhosis include:[5]
References
- ↑ Prince M, Chetwynd A, Newman W, Metcalf JV, James OF (2002). "Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years". Gastroenterology. 123 (4): 1044–51. PMID 12360466.
- ↑ 2.0 2.1 Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A; et al. (1990). "The demography of primary biliary cirrhosis in Ontario, Canada". Hepatology. 12 (1): 98–105. PMID 2197212.
- ↑ Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D (2006). "Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence". Hepatology. 44 (1): 91–8. doi:10.1002/hep.21230. PMID 16800007.
- ↑ Laurin JM, DeSotel CK, Jorgensen RA, Dickson ER, Lindor KD (1994). "The natural history of abdominal pain associated with primary biliary cirrhosis". Am J Gastroenterol. 89 (10): 1840–3. PMID 7942679.
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.