Primary biliary cirrhosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include elevated levels of bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, anti-mitochondrial antibodies, lipids, immunoglobulin M, liver aminotransferases.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:[1][2][3][4]
- Hyperbilirubinemia
- Elevated alkaline phosphatase (2–10 times upper limit of normal)
- Elevated gamma-glutamyl transpeptidase (GGT)
- Elevated serum anti-mitochondrial antibodies (AMA) in more than 90% patients (titres of 1/40 or greater)
- Hyperlipidemia
- Elevated immunoglobulin M
- Elevated liver aminotransferase
- Some patients with primary biliary cirrhosis may have "nuclear-rim" and "multiple nuclear-dot" patterns, which is highly specific for primary biliary cirrhosis, particularly in AMA-negative patients.
- Some patients with primary biliary cirrhosis may have elevated antinuclear antibody (35% patients) and anti-smooth muscle antibody (66% patients).
References
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.
- ↑ Talwalkar JA, Lindor KD (2003). "Primary biliary cirrhosis". Lancet. 362 (9377): 53–61. doi:10.1016/S0140-6736(03)13808-1. PMID 12853201.
- ↑ Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ; et al. (1986). "Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?". Hepatology. 6 (6): 1279–84. PMID 3793004.
- ↑ Crippin JS, Lindor KD, Jorgensen R, Kottke BA, Harrison JM, Murtaugh PA; et al. (1992). "Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk?". Hepatology. 15 (5): 858–62. PMID 1568727.