Umbilical vein
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| Vein: Umbilical vein | |
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| Fetal circulation; the umbilical vein is the large, red vessel at the far left. | |
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| Human embryo about fifteen days old. Brain and heart represented from right side. Digestive tube and yolk sac in median section. (Umbilical vein labeled at bottom right.) | |
| Latin | vena umbilicalis |
| Gray's | subject #135 519 |
| Artery | umbilical artery |
| Dorlands / Elsevier | v_05/12852143 |
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The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus.
Circulation
Attached to the uterine lining, the placenta is the site of gas exchange between mother and fetus. The singular umbilical vein carries oxygenated blood from the placenta to the fetus, while two umbilical arteries return deoxygenated blood to the placenta. The three vessels coil around one another within the Wharton's jelly of the umbilical cord and enter the abdomen at the umbilicus.
Inside the fetus, the vein courses alongside the falciform ligament and then to the liver's underside. At the transverse fissure, the vein divides into two vessels, one larger than the other. The larger of the two is joined by the portal vein, and together they enter the right lobe of the liver. The smaller vessel, now called the ductus venosus, diverges away from the liver and joins with the inferior vena cava.
Closure
Within a week of birth, the infant's umbilical vein is completely obliterated and is replaced by a fibrous cord called the round ligament of the liver (also called the ligamentum teres hepatis, from the Latin meaning the same). It extends from the umbilicus to the transverse fissure, where it joins with the ligamentum venosum to separate the left and right lobes of the liver.
Closure of the umbilical vein usually occurs after the umbilical arteries have closed. This prolongs the communication between the placenta and fetal heart, allowing for a sort of autotransfusion of remaining blood from the placenta to the fetus.
Recanalization
Under extreme pressure, the round ligament may reopen to allow the passage of blood. Such recanalization is common in patients with cirrhosis and portal hypertension. Patients with cirrhosis experience rapid growth of scar tissue in and around the liver, often functionally obstructing nearby vessels. Vessel occlusion increases vascular resistance and therefore leads to hypertension. In portal hypertension, the vessels surrounding the liver are subjected to abnormally high blood pressure—so high, in fact, that the force of the blood pressing against the round ligament is sufficient to recanalize the structure.
Catheterization
A newborn baby has a patent umbilical vein for at least a few months. This umbilical vein may be catheterised for ready intravenous access. It may be used as a site for regular transfusion in cases of erythroblastosis or hemolytic disease.
Additional images
 Model of human embryo 1.3 mm. long. |
 Scheme of placental circulation. |
 Diagram of the vascular channels in a human embryo of the second week. |
 Human embryo with heart and anterior body-wall removed to show the sinus venosus and its tributaries. |
 Schematic figure of the bursa omentalis, etc. Human embryo of eight weeks. |
 Liver with the septum transversum. Human embryo 3 mm. long. |
 Tail end of human embryo twenty-five to twenty-nine days old. |
References
See also
Prenatal development/Mammalian development of circulatory system | |
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| Vascular | Blood island
arteries: Dorsal aorta - Aortic arches - Vitelline arteries - Ductus arteriosus - Umbilical artery |
| Heart development | Primitive heart tube: Truncus arteriosus - Bulbus cordis - Primitive ventricle - Primitive atrium - Sinus venosus Septum primum (Ostium primum, Ostium secundum) - Septum secundum (Foramen ovale) - other septa (Endocardial cushions/Septum intermedium, Aorticopulmonary septum) - Atrial canal |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
