Tumor lysis syndrome diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The diagnosis of tumor lysis syndrome is based on the Cairo–Bishop criteria, which includes uric acid, potassium, phosphorous, and calcium.

Diagnostic Criteria

The diagnosis of tumor lysis syndrome is based on the Cairo–Bishop criteria:

Category	Diagnostic criteria
Laboratory tumor lysis syndrome	Abnormality in two or more of the following within 3 days before or 7 days after starting chemotherapy: Hyperuricemia ≥ 476 μmol/l Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults) Hyperkalemia ≥ 6·0 mmol/l Hypocalcemia ≤ 1·75 mmol/l
Clinical tumor lysis syndrome	Laboratory tumor lysis syndrome plus one or more of the following: Increase serum creatinine (1.5 times upper normal limit) Cardiac arrhythmia Sudden death Seizure