Sufentanil
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| Image:Sufentanil Structure.png | |
| Sufentanil
| |
| Systematic (IUPAC) name | |
| N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl) -4-piperidyl]-N-phenyl-propanamide | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C22H30N2O2S |
| Mol. mass | 386.552 g/mol |
| Physical data | |
| Melt. point | 97 °C (207 °F) |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 265 minutes |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Schedule II (USA) |
| Routes | Injection |
Sufentanil is a synthetic opioid analgesic drug approximately 5 to 10 times more potent than fentanyl. Sufentanil is marketed for use by specialist centres under different trade names, such as Sufenta and Sufentil (India, by Claris Lifesciences Ltd.). Sufentanil was discovered at Janssen Pharmaceutica.
Uses
The main use of this medication is in operating suites and critical care where pain relief is required for a short period of time. It also offers properties of sedation and this makes it a good analgesic component of anaesthetic regimen during an operation. It is usually administered under the doctor's order through an intravenous route. In some countries sufentanil is only indicated for epidural use, despite this, it is often used off-label both intravenously and intranasally. A transdermal sufentanil patch called Transdur-sufentanil is currently in Stage I clinical trials by ENDO pharmaceuticals for the relief of chronic pain, and has the advantage over fentanyl patches such as Duragesic of only needing to be applied once per week.
Side effects
It is essential for the administering doctor to be trained in airway management with readily available airway equipment because the drug causes significant respiratory depression and may cause respiratory arrest if given too much too rapidly. Other opioid side effects such as heart rhythm irregularity, blood pressure changes and nausea/vomiting can also be present in patients given this drug and should be dealt with accordingly by the doctor or anesthetist.
External links
de:Sufentanil fr:Sufentanil it:Sufentanil sv:Sufentanil th:ซูเฟนทานิล
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
