Small cell carcinoma of the lung historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Guillermo Rodriguez Nava, M.D. [2] Mirdula Sharma, MBBS [3]


Laennec first recognized lung cancer as a separate disease in 1815, in his work "Encephaloides" published in the Dictionnaire des sciences médicales. Azzopardi, in 1959, distinguished small cell lung cancer (SCLC) from anaplastic adenocarcinoma and squamous cell carcinoma and described the clinical and biological features that characterize it as a separate disease.

Historical Perspective

Important landmarks in the history of small cell carcinoma of the lung include the following:


  1. 1.0 1.1 1.2 ROSENBLATT MB (1964). "LUNG CANCER IN THE 19TH CENTURY". Bull Hist Med. 38: 395–425. PMID 14213122.
  2. 2.0 2.1 Barnard, W. G. (1926). "The nature of the "oat-celled sarcoma" of the mediastinum". The Journal of Pathology and Bacteriology. 29 (3): 241–244. doi:10.1002/path.1700290304. ISSN 0368-3494.
  3. DOLL R, HILL AB (1950). "Smoking and carcinoma of the lung; preliminary report". Br Med J. 2 (4682): 739–48. PMC 2038856. PMID 14772469.
  4. AZZOPARDI JG (1959). "Oat-cell carcinoma of the bronchus". J Pathol Bacteriol. 78: 513–9. PMID 13795444.
  5. WATSON WL, BERG JW (1962). "Oat cell lung cancer". Cancer. 15: 759–68. PMID 14005321.
  6. Green RA, Humphrey E, Close H, Patno ME (1969). "Alkylating agents in bronchogenic carcinoma". Am J Med. 46 (4): 516–25. PMID 5791000.
  7. Lowenbraun S, Bartolucci A, Smalley RV, Lynn M, Krauss S, Durant JR (1979). "The superiority of combination chemotherapy over single agent chemotherapy in small cell lung carcinoma". Cancer. 44 (2): 406–13. PMID 224997.
  8. Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus: ten-year follow-up. Lancet1973;2: 63–65.
  9. Mountain CF. Clinical biology of small cell carcinoma: relationship to surgical therapy. Semin Oncol 1978; 5: 272–79
  10. Greco FA, Richardson RL, Snell JD, Stroup SL, Oldham RK (1979). "Small cell lung cancer. Complete remission and improved survival". Am J Med. 66 (4): 625–30. PMID 219690.
  11. Bunn PA, Greco FA, Einhorn L (1986). "Cyclophosphamide, doxorubicin, and etoposide as first-line therapy in the treatment of small-cell lung cancer". Semin Oncol. 13 (3 Suppl 3): 45–53. PMID 3020700.
  12. "The World Health Organization histological typing of lung tumours. Second edition". Am J Clin Pathol. 77 (2): 123–36. 1982. PMID 7064914.
  13. Hirsch FR, Matthews MJ, Aisner S, Campobasso O, Elema JD, Gazdar AF; et al. (1988). "Histopathologic classification of small cell lung cancer. Changing concepts and terminology". Cancer. 62 (5): 973–7. PMID 2842029.
  14. Junker K, Wiethege T, Müller KM (2000). "Pathology of small-cell lung cancer". J Cancer Res Clin Oncol. 126 (7): 361–8. PMID 10929757.
  15. Miller CW, Simon K, Aslo A, Kok K, Yokota J, Buys CH; et al. (1992). "p53 mutations in human lung tumors". Cancer Res. 52 (7): 1695–8. PMID 1312896.
  16. Helin K, Holm K, Niebuhr A, Eiberg H, Tommerup N, Hougaard S; et al. (1997). "Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma". Proc Natl Acad Sci U S A. 94 (13): 6933–8. PMC 21262. PMID 9192669.
  17. Fong KM, Sekido Y, Minna JD (1999). "Molecular pathogenesis of lung cancer". J Thorac Cardiovasc Surg. 118 (6): 1136–52. PMID 10595998.
  18. 18.0 18.1 Vestergaard J, Pedersen MW, Pedersen N, Ensinger C, Tümer Z, Tommerup N; et al. (2006). "Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro". Lung Cancer. 52 (3): 281–90. doi:10.1016/j.lungcan.2005.12.014. PMID 16616798.
  19. Aupérin A, Arriagada R, Pignon JP, Le Péchoux C, Gregor A, Stephens RJ; et al. (1999). "Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group". N Engl J Med. 341 (7): 476–84. doi:10.1056/NEJM199908123410703. PMID 10441603.
  20. Sundstrøm S, Bremnes RM, Kaasa S, Aasebø U, Hatlevoll R, Dahle R; et al. (2002). "Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years' follow-up". J Clin Oncol. 20 (24): 4665–72. PMID 12488411.
  21. Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A, Jones D; et al. (2010). "A small-cell lung cancer genome with complex signatures of tobacco exposure". Nature. 463 (7278): 184–90. doi:10.1038/nature08629. PMC 2880489. PMID 20016488.