Editor-In-Chief: C. Michael Gibson, M.S., M.D.  Phone:617-632-7753
Simmonds' disease (also Simmonds' syndrome) refers to panhypopituitarism caused by the destruction of the pituitary gland due to infiltrative processes (e.g. lymphocytic), tumours (pituitary adenomas or craniopharyngiomas) or trauma (cranial injury or following surgery).
Sheehan's syndrome is a sub-classification of Simmond's disease occurring specifically in the peripartum period.
It was first described by Morris Simmonds when a patient presented with 'fatal cachexia', although his patient went on to live for 11 more years. 
Although cachexia may be present, the disease is characterised by symptoms due to decreased gonadal, thyroidal and adrenal function. These include:
- ↑ Simmonds M, (1914) Dtsch. med. Wschr. 40, 322
- ↑ synd/2008 at Who Named It
|Endocrine pathology: endocrine diseases (E00-35, 240-259)|
|Thyroid||Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) - Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) - Euthyroid sick syndrome|
|Pancreas||Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor (Rabson-Mendenhall syndrome)|
|Parathyroid||Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary)|
|Pituitary||Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) - Hypopituitarism (Simmonds' disease/Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) - Adiposogenital dystrophy - Empty sella syndrome|
|Adrenal||Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - CAH (Lipoid, 3β, 11β, 17α, 21α) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism|
|Gonads||ovarian dysfunction (Polycystic ovary syndrome, Premature ovarian failure) - testicular dysfunction (5-alpha-reductase deficiency) - testosterone biosynthesis (17-beta-hydroxysteroid dehydrogenase deficiency) - general (Hypogonadism, Delayed puberty, Precocious puberty)|
|Other||Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria - Woodhouse-Sakati syndrome|