Serotype
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Overview
For the term's use in bacteriology, see serovar.
Serotype (Allograft)
Transplants between genetically non-identical humans induce the creation of antibodies in the recipient. These non-identical cell-surface receptors between the donor and recipient produce antiserum reactive to the donor proteins. Under selection conditions one or two isoform specificities are obtained. This results in a serotype that is capable of identifying other individuals who have those proteins. This serotyping along with new-PCR based techniques are how tissues for organ-donor programs are characterized. (for more detailed information see Human leukocyte antigens and HLA Serotype tutorial)
| HLA | # of | Broad | Split |
|---|---|---|---|
| Locus | Serotypes | Antigens | Antigens |
| A | 25 | 4 | 15 |
| B | 50 | 9 | 24 |
| C* | 12 | 1 | 2 |
| DR | 21 | 4 | 8 |
| DQ | 8 | 2 | 5 |
| DP* | |||
| *DP and many Cw require SSP-PCR for typing. | |||
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
