HLA-C

Major histocompatibility complex, class I, C
Identifiers
Symbol(s)	HLA-C; Cw*1701; D6S204; FLJ27082; HLA-JY3; HLC-C; PSORS1
External IDs	OMIM: 142840 Homologene: 86715
Gene ontology Molecular Function: • microtubule motor activity • MHC class I receptor activity • MHC class II receptor activity Cellular Component: • axonemal dynein complex • integral to plasma membrane • membrane • integral to membrane • MHC class I protein complex Biological Process: • ciliary or flagellar motility • antigen processing and presentation of peptide antigen via MHC class I • immune response • antigen processing and presentation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3107	667977
Ensembl	ENSG00000204525	na
Uniprot	P10321	na
Refseq	XM_001131707 (mRNA) XP_001131707 (protein)	XM_001003863 (mRNA) XP_001003863 (protein)
Location	Chr 6: 31.34 - 31.35 Mb	na
Pubmed search	[1]	[2]

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6 that encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

Disease Associations

By Serotype

Cw1: Multinodular goiters

By Allele

Cw*16: B chronic lymphocytic leukaemia

Nomenclature

Cw*01

• Cw1 Serotype: Cw*0102 and Cw*0109
• Cw11 ?
• Cw*0104 to *0108

Cw*02

• Cw2 Serotype: Cw*0202 and *0208
• Cw*0203 to *0207, and 0209

Cw*03

• Cw9 Serotype: Cw*0303
• Cw10 Serotype: Cw*0302, *0304, and *0306
• Cw3 Serotype: Cw*0307
• Cw*0305 and 0308

Cw*04

• Cw4 Serotype: Cw*0401, *0407, and *0410

Cw*05

• Cw5 Sertoype: Cw*0501 and *0502
• Cw*0503 to *506 and *0508 to *0510

Cw*06

• Cw6 Serotype: Cw*0602 and *0605
• Cw6*0603, *0604 and *0606 to *0611

• Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
• Cw*0707 to *0711, *0713, *0715, and *0717 to *0729

Cw*08

• Cw8 Serotype: Cw*0801, *0802 and *0803
• Cw*805 to *0812

Cw*1202 to *1215

Cw*1402 to *1405

Cw*1501 to *1511

Cw*1601 to *1606

Cw*1701 to *1703

Cw*1801 and *1802

Common Haplotype

Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)

Further reading

• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580-5. doi:10.1093/embo-reports/kve141. PMID 11463741.
• Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323-35. PMID 12734410.
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris) 19 (1): 100-6. PMID 12836198.
• Leavitt SA, SchOn A, Klein JC, et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci. 5 (1): 1-8. PMID 14965316.
• Tolstrup M, Ostergaard L, Laursen AL, et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Curr. HIV Res. 2 (2): 141-51. PMID 15078178.
• Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87-94. PMID 15638726.
• Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports 1 (1): 47-53. PMID 16091223.

External links

• Molecular Anthropology Yahoo Group
  
• HLA Allele and Haplotype Frequency Database