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ICD-10 O40
ICD-9 657
DiseasesDB 10319
MedlinePlus 003267
MeSH D006831

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Polyhydramnios (polyhydramnion, hydramnios) is the medical condition of too much amniotic fluid in the amniotic sac. It is seen in 0.5 to 2% of pregnancies.

The opposite to Polyhydramnios is Oligohydramnios. This is a deficiency in amniotic fluid. It is very rare.


Polyhydramnios is generally due to maternal diabetes (around 20% of cases) and results from hyperglycemia of the fetus which results in fetal polyuria (fetal urine is a major source of amniotic fluid). About 20% of the cases of polyhydramnios are associated with fetal anomalies that impairs the ability of the fetus to swallow (because the fetus normally swallows amniotic fluid and absorbs it through its intestinal villi). This includes:

In a multiple gestation pregnancy, twin-twin transfusion syndrome is usually the cause.

Associated conditions

Fetuses with polyhydramnios are at risk for a number of other problems including cord prolapse, placental abruption and perinatal death. At delivery the baby should be checked for congenital abnormalities.


In some cases, amnioreduction has been used in response to polyhydramnios.[1]


  1. Piantelli G, Bedocchi L, Cavicchioni O; et al. (2004). "Amnioreduction for treatment of severe polyhydramnios". Acta bio-medica : Atenei Parmensis. 75 Suppl 1: 56–8. PMID 15301292.

Cost Effectiveness of Polyhydramnios

| group5 = Clinical Trials Involving Polyhydramnios | list5 = Ongoing Trials on Polyhydramnios at Clinical Trials.govTrial results on PolyhydramniosClinical Trials on Polyhydramnios at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Polyhydramnios | list6 = US National Guidelines Clearinghouse on PolyhydramniosNICE Guidance on PolyhydramniosNHS PRODIGY GuidanceFDA on PolyhydramniosCDC on Polyhydramnios

| group7 = Textbook Information on Polyhydramnios | list7 = Books and Textbook Information on Polyhydramnios

| group8 = Pharmacology Resources on Polyhydramnios | list8 = AND (Dose)}} Dosing of PolyhydramniosAND (drug interactions)}} Drug interactions with PolyhydramniosAND (side effects)}} Side effects of PolyhydramniosAND (Allergy)}} Allergic reactions to PolyhydramniosAND (overdose)}} Overdose information on PolyhydramniosAND (carcinogenicity)}} Carcinogenicity information on PolyhydramniosAND (pregnancy)}} Polyhydramnios in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Polyhydramnios

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Polyhydramnios | list9 = AND (pharmacogenomics)}} Genetics of PolyhydramniosAND (pharmacogenomics)}} Pharmacogenomics of PolyhydramniosAND (proteomics)}} Proteomics of Polyhydramnios

| group10 = Newstories on Polyhydramnios | list10 = Polyhydramnios in the newsBe alerted to news on PolyhydramniosNews trends on Polyhydramnios

| group11 = Commentary on Polyhydramnios | list11 = Blogs on Polyhydramnios

| group12 = Patient Resources on Polyhydramnios | list12 = Patient resources on PolyhydramniosDiscussion groups on PolyhydramniosPatient Handouts on PolyhydramniosDirections to Hospitals Treating PolyhydramniosRisk calculators and risk factors for Polyhydramnios

| group13 = Healthcare Provider Resources on Polyhydramnios | list13 = Symptoms of PolyhydramniosCauses & Risk Factors for PolyhydramniosDiagnostic studies for PolyhydramniosTreatment of Polyhydramnios

| group14 = Continuing Medical Education (CME) Programs on Polyhydramnios | list14 = CME Programs on Polyhydramnios

| group15 = International Resources on Polyhydramnios | list15 = Polyhydramnios en EspanolPolyhydramnios en Francais

| group16 = Business Resources on Polyhydramnios | list16 = Polyhydramnios in the MarketplacePatents on Polyhydramnios

| group17 = Informatics Resources on Polyhydramnios | list17 = List of terms related to Polyhydramnios


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