Orotidine 5'-phosphate decarboxylase
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| Orotidine 5'-monophosphate decarboxylase | |
|---|---|
| Image:OMP decarboxylase.png E. coli OMP decarboxylase, drawn from PDB 1EIX | |
| Other names: | OMP decarboxylase, Orotidylic decarboxylase, Orotate decarboxylase, UMP synthase |
| Protein Structure/Function | |
| Molecular Weight: | 26,500 monomer (E.coli) (Da) |
| Structure: | Dimer in solution |
| Protein type: | Enzyme Decarboxylase |
| Functions: | Converts OMP to UMP |
| Other | |
| Taxa expressing: | Plants, fungi, bacteria and animals |
| Cell types: | Cytoplasm |
| Subcellular localization: | General |
| Pathway(s): | Pyrimidine metabolism |
| Enzymatic Data | |
| Cofactor(s): | None |
| Enzyme Regulation: | Product inhibition |
| Medical/Biotechnological data | |
| Diseases: | Oroticaciduria II |
| Pharmaceuticals: | allopurinol |
| Related information | |
| Related articles: | BRENDA and ENZYME |
Orotidine 5'-phosphate decarboxylase is an enzyme involved in pyrimidine metabolism.
Function
The enzyme converts orotidine monophosphate (OMP) to uridine monophosphate (UMP) by liberating carbon dioxide. It is known for being an extraordinarily efficient catalyst capable of accelerating the uncatalyzed reaction rate by a factor of 1017. To put it in perspective, the enzyme can catalyze the substrate in 18 milliseconds, in a reaction that would take 78 million years to complete without the enzyme. [1][1]
Unicellular vs Multicellular Function
In yeast and bacteria OMP decarboxylase is a single-function enzyme. However, in mammals, OMP decarboxylase is part of a single protein with two catalytic activities. This bifunctional enzyme is named UMP synthase and it also catalyzes the preceding reaction in pyrimidine nucleotide biosynthesis, the transfer of ribose 5-phosphate from 5-phosphoribosyl-1-pyrophosphate to orotate to form OMP.[1]
References
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
