Hashimoto's thyroiditis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
The mainstay of therapy for Hashimoto's thyroiditis is synthetic levothyroxine. Corticosteroids and selenium can also be used in certain cases.
Medical Therapy
The drugs used in the treatment of Hashimoto's thyroiditis are:[1][2]
- Levothyroxine:
- lifelong synthetic levothyroxine (L-T4) is used to treat the hypothyroidism in Hashimoto's disease.
- Main goals of levothyroxine replacement therapy are:
- Resolution of the hypothyroid symptoms and signs including biological and physiologic markers of hypothyroidism
- Normalization of serum thyrotropin with improvement in thyroid hormone concentrations
- To avoid overtreatment (iatrogenic thyrotoxicosis)
- Side effects include atrial fibrillation and osteoporosis
- Corticosteroids:
- A short course of glucocorticoids can be used in the treatment of IgG4-related variant of Hashimoto's thyroiditis.
- Selenium:
- Dietary selenium supplementation is considered to be protective against the autoimmune diseases of the thyroid.
Drug Regimen:
- Synthetic levothyroxine (L-T4) 1.6–1.8 μg/kg of body weight per day orally.
References
- ↑ Caturegli P, De Remigis A, Rose NR (2014). "Hashimoto thyroiditis: clinical and diagnostic criteria". Autoimmun Rev. 13 (4–5): 391–7. doi:10.1016/j.autrev.2014.01.007. PMID 24434360.
- ↑ Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM (2014). "Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement". Thyroid. 24 (12): 1670–751. doi:10.1089/thy.2014.0028. PMC 4267409. PMID 25266247.