HLA-A74
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| major histocompatibility complex (human), class I, A74
| ||
| Alleles | A*7401 A*7403 | |
| Structure (See HLA-A) | ||
| Identifiers | 7401 7403
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*7401 | |
| EBI-HLA | A*7403 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A74 (A74) is an HLA-A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.
Serotype
| A*74 | A74 | A19 | Sample |
| allele | % | % | size (N) |
| 7401 | 40 | 11 | 119 |
| 7401 | 17 | 29 |
Disease associations
A significant association has been found between A74 and nasal polyposis.[2]
A*74 allele Frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Kenya | 9.7 |
| [3] | Cameroon Beti | 8.3 |
| [3] | Guinea Bissau | 7.7 |
| [3] | Burkina Faso Mossi | 6.6 |
| [3] | Uganda Kampala | 5.2 |
| [3] | Cameroon Yaounde | 5.0 |
| [3] | Cameroon Bamileke | 4.5 |
| [3] | Cameroon Sawa | 3.8 |
| [3] | Mali Bandiagara | 3.6 |
| [3] | Iran Baloch | 2.8 |
| [3] | Zimbabwe Harare Shona | 2.7 |
| [3] | Senegal Niokholo Mandenka | 2.2 |
| [3] | Burkina Faso Rimaibe | 2.1 |
| [3] | Kenya Nandi | 1.7 |
| [3] | Morocco Nador Metalsa | 1.4 |
| [3] | Thailand Northeast | 1.2 |
| [3] | Thailand | 1.1 |
| [3] | Jordon Amman | 0.7 |
| [3] | Jordon Amman | 0.5 |
| [3] | China South | 0.5 |
| freq | ||
| ref. | Population | (%) |
| [3] | Kenya Luo | 7.3 |
| [3] | Iran Baloch | 0.6 |
| [3] | Kenya | 0.3 |
| [3] | Uganda Kampala | 0.3 |
References
- ↑ derived from IMGT/HLA
- ↑ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 257 (3): 137–9. PMID 10839486.
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
HLA-A serotypes |
|---|
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
