HLA-A25
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| major histocompatibility complex (human), class I, A25
| ||
| Alleles | A*2501 A*2502 | |
| Structure (See HLA-A) | ||
| Identifiers | 2501 2502
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*2501 | |
| EBI-HLA | A*2502 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A25 (A25) is an HLA-A serotype. The serotype identifies the more common HLA-A*25 gene products. A25 is a split antigen of the A10 broad antigen serotype group. It is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A26 is more common in Western Europe.
Serotype
| A*25 | A25 | A10 | Sample |
| allele | % | % | size (N) |
| 2501 | 95 | 2 | 1375 |
| 2502 | 80 | 5 |
There are 7 alleles for A25, 6 that result in different isoforms.
A25 frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Saudi Arabia | 5.7 |
| [3] | India Jalpaiguri Toto | 5.2 |
| [3] | Russia Northwest | 5.0 |
| [3] | Spain Pas Valley | 4.3 |
| [3] | Czech Republic | 4.2 |
| [3] | Spain North Cantabrian | 4.2 |
| [3] | Russia Arkhangelsk Pomors | 4.0 |
| [3] | Croatia | 3.9 |
| [3] | Spain North Cabuernigo | 3.8 |
| [3] | Russia Chuvash | 3.7 |
| [3] | Romanian | 3.5 |
| [3] | Italy Bergamo | 3.2 |
| [3] | Croatia | 3.0 |
| [3] | Israel Ashkenazi Jews | 2.8 |
| [3] | Bulgaria | 2.7 |
| [3] | Spain Basque Arratia Valley | 2.7 |
| [3] | Sweden Uppsala County | 2.6 |
| [3] | Ireland Northern | 2.1 |
| [3] | Turkey | 2.1 |
| [3] | Wales | 2.1 |
| [3] | Spain Eastern Andalusia | 2.0 |
| [3] | Georgia Svaneti Svans | 1.9 |
| [3] | Italy | 1.9 |
| [3] | England Manchester | 1.9 |
| [3] | England Lancaster | 1.8 |
| [3] | Jews (Israel) | 1.7 |
| [3] | Macedonia | 1.7 |
| [3] | England Sheffield | 1.6 |
| [3] | Portugal South pop2 | 1.4 |
| [3] | Italy South Campania | 1.2 |
| [3] | Uganda Kampala | 1.2 |
| [3] | Finland | 1.1 |
| [3] | Portugal North | 1.1 |
| [3] | Belgium | 1.0 |
| [3] | France Corsica | 1.0 |
| [3] | Mongolia Oold | 1.0 |
| [3] | Russia Murmansk Saomi | 1.0 |
| [3] | Tunisia | 1.0 |
| [3] | France South East | 0.8 |
| [3] | Morocco Nador Metalsa | 0.7 |
| [3] | Greece | 0.6 |
| [3] | Italy North Pavia | 0.6 |
| [3] | Algeria | 0.5 |
| [3] | China Qinghai Hui | 0.5 |
| [3] | Guatemala Mayans | 0.4 |
| [3] | Russia Nenets | 0.4 |
| [3] | Cameroon Beti | 0.3 |
| [3] | Beijing Shijiazhuang | 0.1 |
| [3] | Taiwan Hakka | 0.1 |
A*2501 distribution is primarily located in western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.
References
- ↑ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
- ↑ derived from IMGT/HLA
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 3.48 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
HLA-A serotypes |
|---|
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
