Fructose 1,6-bisphosphate

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Fructose 1,6-bisphosphate
Identifiers
CAS number 488-69-7
PubChem 172313
MeSH fructose-1,6-diphosphate
SMILES C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O
Properties
Molecular formula C6H14O12P2
Molar mass 340.116
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Fructose 1,6-phosphate is fructose sugar phosphorylated on carbons 1 and 6 (ie. is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-phosphate at some point.

Fructose 1,6-phosphate in glycolysis

Fructose 1,6-phosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is in turn broken down into two compounds; glyceraldehyde 3-phosphate and glycerone phosphate. It is allosteric activator of pyruvate kinase.

β-D-fructose 6-phosphate 6-phosphofructo 1-kinase β-D-fructose 1,6-phosphate Fructose bisphosphate aldolase D-glyceraldehyde 3-phosphate dihydroxyacetone phosphate
image:beta-D-fructose-6-phosphate_wpmp.png image:beta-D-fructose-1,6-bisphosphate_wpmp.png image:D-glyceraldehyde-3-phosphate_wpmp.png + image:glycerone-phosphate_wpmp.png
ATP ADP
image:Biochem_reaction_arrow_reversible_YYYY_horiz_med.png image:Biochem_reaction_arrow_reversible_NNNN_horiz_med.png
Pi H2O
Hexose diphosphatase Fructose bisphosphate aldolase


The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Fructose 1,6-phosphate isomerism

Main article: Fructose

Fructose 1,6-phosphate has only one biologically active isomer, the β-D-form. There are many other isomers, analogous to those of fructose.

See also

 v  d  e 
Glycolysis Metabolic Pathway
Glucose Hexokinase Glucose-6-phosphate Phosphoglucoisomerase Fructose 6-phosphate Phosphofructokinase Fructose 1,6-bisphosphate Fructose bisphosphate aldolase Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde phosphate dehydrogenase
ATP ADP ATP ADP NAD+ + Pi NADH + H+
+ 2
NAD+ + Pi NADH + H+
1,3-Bisphosphoglycerate Phosphoglycerate kinase 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Enolase Phosphoenolpyruvate Pyruvate kinase Pyruvate Pyruvate dehydrogenase Acetyl-CoA
ADP ATP H2O ADP ATP CoA + NAD+ NADH + H+ + CO2
2 2 2 2 2 2
ADP ATP H2O
Template:Metabolic pathway stub

fr:Fructose 1,6-diphosphate

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